Age-dependent changes in gastrointestinal motility

Abstract

The mechanisms of the motor function are studied for more than 100 years, howe ver, they have not been established completely. Understanding those mechanisms is of great importance since the disturbances of gastrointestinal motility underlay in patho geneses of many diseases, such as colitis, constipations, irritable bowel syndrome and others. This review is devoted to analysis of literature data of the agerelated changes in the motility function of digestive tract. We have searched articles on a particular issue and have analyzed them in accordance with the parts of the digestive tract. Main atten tion has been paid to agedependent functional and regulatory changes in the digestive tract. The mechanisms underlying in pathogenesis of agerelated diseases of motor function of the digestive tract have not been deeply studied. Without the establishment of these mechanisms, it is impossible to create new drugs for prophylaxis and treatment of agerelated disturbances in motor function of the gastrointestinal (GI) motility.