Age-Dependent Alteration in Hippocampal Neurogenesis Correlates with Learning Performance of Macaque Monkeys

Aizawa, Ken; Ageyama, Naohide; Yokoyama, Chihiro; Hisatsune, Tatsuhiro

doi:10.1538/expanim.58.403

Cited by 63 publications

(54 citation statements)

References 23 publications

(27 reference statements)

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“…One month after testing their spatial memory abilities in the water maze, it was found that animals with preserved spatial reference memory, that is, aged-unimpaired rats, showed a higher level of cell proliferation and a higher number of new neurons in comparison to rats with spatial memory impairments, that is, aged-impaired rats (Drapeau et al 2003). This correlative relation was confirmed in rats (Driscoll et al 2006), monkeys (Aizawa et al 2009), and, recently, in humans (Coras et al 2010), reinforcing its physiological significance.…”

Section: Correlationsmentioning

confidence: 79%

Interaction between Neurogenesis and Hippocampal Memory System: New Vistas

Abrous

Wojtowicz

2015

Cold Spring Harb Perspect Biol

101

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During the last decade, the questions on the functionality of adult neurogenesis have changed their emphasis from if to how the adult-born neurons participate in a variety of memory processes. The emerging answers are complex because we are overwhelmed by a variety of behavioral tasks that apparently require new neurons to be performed optimally. With few exceptions, the hippocampal memory system seems to use the newly generated neurons for multiple roles. Adult neurogenesis has given the dentate gyrus new capabilities not previously thought possible within the scope of traditional synaptic plasticity. Looking at these new developments from the perspective of past discoveries, the science of adult neurogenesis has emerged from its initial phase of being, first, a surprising oddity and, later, exciting possibility, to the present state of being an integral part of mainstream neuroscience. The answers to many remaining questions regarding adult neurogenesis will come along only with our growing understanding of the functionality of the brain as a whole. This, in turn, will require integration of multiple levels of organization from molecules and cells to circuits and systems, ultimately resulting in comprehension of behavioral outcomes.

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Section: Correlationsmentioning

confidence: 79%

Interaction between Neurogenesis and Hippocampal Memory System: New Vistas

Abrous

Wojtowicz

2015

Cold Spring Harb Perspect Biol

101

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“…Although there is no overt age-related loss of neurons in the monkey hippocampus, aged monkeys have fewer proliferating cells in the DG subgranular zone, and these cells also exhibit shorter and irregularly oriented dendritic processes (Aizawa et al 2009(Aizawa et al , 2011. These studies suggest that aged monkeys have attenuated hippocampal neurogenesis (Aizawa et al 2009), possibly due to decreased survival of immature neurons (Aizawa et al 2011).…”

Section: Neurons Of the Hippocampus And Related Cortical Regionsmentioning

confidence: 79%

“…These studies suggest that aged monkeys have attenuated hippocampal neurogenesis (Aizawa et al 2009), possibly due to decreased survival of immature neurons (Aizawa et al 2011). Additionally, preliminary findings point to a potential relationship between the number of proliferating cells in the subgranular zone and learning capacity (Aizawa et al 2009). …”

Section: Neurons Of the Hippocampus And Related Cortical Regionsmentioning

confidence: 92%

Neuronal and morphological bases of cognitive decline in aged rhesus monkeys

Hara

Rapp

Morrison

2011

AGE

120

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Rhesus monkeys provide a valuable model for studying the basis of cognitive aging because they are vulnerable to age-related decline in executive function and memory in a manner similar to humans. Some of the behavioral tasks sensitive to the effects of aging are the delayed response working memory test, recognition memory tests including the delayed nonmatching-to-sample and the delayed recognition span task, and tests of executive function including reversal learning and conceptual set-shifting task. Much effort has been directed toward discovering the neurobiological parameters that are coupled to individual differences in age-related cognitive decline. Area 46 of the dorsolateral prefrontal cortex (dlPFC) has been extensively studied for its critical role in executive function while the hippocampus and related cortical regions have been a major target of research for memory function. Some of the key age-related changes in area 46 include decreases in volume, microcolumn strength, synapse density, and α1-and α2-adrenergic receptor binding densities. All of these measures significantly correlate with cognitive scores. Interestingly, the critical synaptic subtypes associated with cognitive function appear to be different between the dlPFC and the hippocampus. For example, the dendritic spine subtype most critical to task acquisition and vulnerable to aging in area 46 is the thin spine, whereas in the dentate gyrus, the density of AGE (2012) large mushroom spines with perforated synapses correlates with memory performance. This review summarizes age-related changes in anatomical, neuronal, and synaptic parameters within brain areas implicated in cognition and whether these changes are associated with cognitive decline.

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“…These phenomena occur in these neurogenic regions of the adult brain in rodents as well as in primates, including humans (Eriksson et al, 1998;Gould et al, 1999;Kornack andRakic, 1999, 2001;Spalding et al, 2013). Hip-pocampal neurogenesis is associated with learning and memory (Imayoshi et al, 2008;Aizawa et al, 2009). Altered neurogenesis in the hippocampus has been implicated in major depression (Cameron and Gould, 1994;Czéh et al, 2001;Malberg and Duman, 2003;Snyder et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F]FLT-PET Imaging

Tamura¹,

Takahashi²,

Takata³

et al. 2016

Journal of Neuroscience

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Neural stem cells in two neurogenic regions, the subventricular zone and the subgranular zone (SGZ) of the hippocampal dentate gyrus, can divide and produce new neurons throughout life. Hippocampal neurogenesis is related to emotions, including depression/anxiety, and the therapeutic effects of antidepressants, as well as learning and memory. The establishment of in vivo imaging for proliferative activity of neural stem cells in the SGZ might be used to diagnose depression and to monitor the therapeutic efficacy of antidepressants. Positron emission tomography (PET) imaging with 3Ј-deoxy-3Ј-[

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Age-Dependent Alteration in Hippocampal Neurogenesis Correlates with Learning Performance of Macaque Monkeys

Cited by 63 publications

References 23 publications

Interaction between Neurogenesis and Hippocampal Memory System: New Vistas

Interaction between Neurogenesis and Hippocampal Memory System: New Vistas

Neuronal and morphological bases of cognitive decline in aged rhesus monkeys

Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F]FLT-PET Imaging

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