Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F]FLT-PET Imaging

Tamura, Yasuhisa; Takahashi, Kayo; Takata, Kumi; Eguchi, Akiyo; Yamato, Masayuki; Kume, Satoshi; Nakano, Masayuki; Watanabe, Yasuyoshi; Kataoka, Yosky

doi:10.1523/jneurosci.0220-16.2016

Cited by 23 publications

(15 citation statements)

References 45 publications

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“…Hippocampal neurogenesis is involved in limbic functions, including regulation of emotion, depression and anxiety, as well as therapeutic effects of antidepressants (Bettio et al, ; Cameron & Glover, ; Hyer et al, ; Tamura et al, ). Studies have demonstrated that decreased neurogenesis may be one cause of depression (Tamura et al, ). Indeed, many antidepressants have been shown to stimulate adult hippocampal neurogenesis (Brooker et al, ).…”

Section: Functional Aspects Of New Dgcs In the Adult Hippocampusmentioning

confidence: 99%

Adult neurogenesis in the mammalian dentate gyrus

Abbott

Nigussie

2019

Anat Histol Embryol

120

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Earlier observations in neuroscience suggested that no new neurons form in the mature central nervous system. Evidence now indicates that new neurons do form in the adult mammalian brain. Two regions of the mature mammalian brain generate new neurons: (a) the border of the lateral ventricles of the brain (subventricular zone) and (b) the subgranular zone (SGZ) of the dentate gyrus of the hippocampus. This review focuses only on new neuron formation in the dentate gyrus of the hippocampus. During normal prenatal and early postnatal development, neural stem cells (NSCs) give rise to differentiated neurons. NSCs persist in the dentate gyrus SGZ, undergoing cell division, with some daughter cells differentiating into functional neurons that participate in learning and memory and general cognition through integration into pre‐existing neural networks. Axons, which emanate from neurons in the entorhinal cortex, synapse with dendrites of the granule cells (small neurons) of the dentate gyrus. Axons from granule cells synapse with pyramidal cells in the hippocampal CA3 region, which send axons to synapse with CA1 hippocampal pyramidal cells that send their axons out of the hippocampus proper. Adult neurogenesis includes proliferation, differentiation, migration, the death of some newly formed cells and final integration of surviving cells into neural networks. We summarise these processes in adult mammalian hippocampal neurogenesis and discuss the roles of major signalling molecules that influence neurogenesis, including neurotransmitters and some hormones. The recent controversy raised concerning whether or not adult neurogenesis occurs in humans also is discussed.

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Section: Functional Aspects Of New Dgcs In the Adult Hippocampusmentioning

confidence: 99%

Adult neurogenesis in the mammalian dentate gyrus

Abbott

Nigussie

2019

Anat Histol Embryol

120

View full text Add to dashboard Cite

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“…Recently, we succeeded in establishing quantitative PET imaging methods for evaluating neurogenic activity in the adult brain with probenecid, a drug transporter inhibitor at the blood-brain barrier (BBB). 22 Probenecid is an inhibitor of ATP-binding cassette (ABC) transporter subfamily C members (ABCCs) and solute carrier proteins, such as organic anion transporter 3 (OAT3). [23][24][25] The current study has encouraged us to establish PET imaging for proliferative activity in the hippocampus of adult primates, including monkey and human, with [ 18 F]FLT and probenecid.…”

mentioning

confidence: 99%

“…[23][24][25] The current study has encouraged us to establish PET imaging for proliferative activity in the hippocampus of adult primates, including monkey and human, with [ 18 F]FLT and probenecid. 22 There are some differences in adult neurogenesis between rodents and primates. Indeed, the number of newborn neurons in primates appears to be several times lower than that in rodents.…”

mentioning

confidence: 99%

“…5,12,[26][27][28] However, it has been reported that the relative rate of proliferative activity in the DG of hippocampus is similar between rodents and primates, including cynomolgus and rhesus monkeys when compared at the same age. 29 Since [ 18 F]FLT can detect cell proliferation in neurogenic regions of adult rats under physiologic conditions, 21,22 our [ 18 F]FLT-PET imaging technique with probenecid may be used to establish in vivo imaging for proliferative activity in the DG of adult monkeys. Indeed, we are attempting to establish PET imaging methods for neurogenic activity in adult rhesus monkeys.…”

mentioning

confidence: 99%

“…21,22 Presently, however, no PET imaging methods are available for the assessment of neuronal lineage cells generated from neural stem cells because of the lack of specific PET ligands for each cell type. Therefore, to more fully evaluate the dynamics of neurogenesis in adult primates via PET imaging, future studies should focus on the development of novel PET tracers for neuronal linage cells, and on monitoring the proliferation and differentiation abilities of neural stem cells using each PET ligand.…”

mentioning

confidence: 99%

See 2 more Smart Citations

PET imaging of neurogenic activity in the adult brain: Toward in vivo imaging of human neurogenesis

Tamura

Kataoka

2017

Neurogenesis

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Targeting hippocampal adult neurogenesis using transcription factors to reduce Alzheimer's disease‐associated memory impairments

2018

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Hippocampal adult neurogenesis results in the persisting formation of new neurons that contribute to hippocampal‐dependent learning and memory. This has led to the hypothesis that memory impairments associated with neurodegenerative diseases such as Alzheimer's disease may involve abnormal neurogenesis. Supporting this idea, evidence for decreased adult neurogenesis has been reported in the brain of Alzheimer's disease patients and in several mouse models of the disease. Thus, the development of strategies designed to stimulate the production of new neurons in the diseased brain has raised growing interest. In this review, we discuss putative strategies and present recent studies showing that it is now possible to instruct hippocampal endogenous neural progenitors to adopt an exclusive neuronal fate. We further report how such strategies lead to the rescue of cognitive functions in mouse models of Alzheimer's disease. Altogether, these findings provide the proof‐of‐concept that neurogenesis can be stimulated in the adult brain in vivo, and consequently overcomes pathological memory deficits.

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Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F]FLT-PET Imaging

Cited by 23 publications

References 45 publications

Adult neurogenesis in the mammalian dentate gyrus

Adult neurogenesis in the mammalian dentate gyrus

PET imaging of neurogenic activity in the adult brain: Toward in vivo imaging of human neurogenesis

Targeting hippocampal adult neurogenesis using transcription factors to reduce Alzheimer's disease‐associated memory impairments

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