Age dependence of association between metabolic syndrome and obesity among women

Пинхасов, Б. Б.; Selyatitskaya, V. G.; Karapetyan, A. R.; Galanova, M.; Dobrovolskaya, N. P.

doi:10.1134/s2079057013030107

Cited by 4 publications

(3 citation statements)

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“…Накопление и распределение жировой ткани в различных депо у мужчин и женщин существенно отличается, что отражается на времени развития метаболических нарушений и ассоциированных с этим нарушений. Сравнительный анализ гендерных отличий накопления жира в онтогенезе позволил установить, что во все возрастные периоды в организме женщин преобладает подкожное распределение жировой клетчатки, в то время как у мужчин в большинстве случаев наблюдается большее её накопление в абдоминальной области [73,74]. Однако динамика накопления жировой ткани всё же имеет зависимость от возраста.…”

Section: циркадные ритмы углеводного обмена при патологии ожирениеunclassified

“…У женщин при наличии избыточной массы тела и ожирения до конца второго периода зрелости преобладает гиноидный тип, в последующем же по мере увеличения возраста (в том числе в пожилом возрасте) отмечается рост встречаемости андроидного типа ожирения [74]. Интересно, что возраст, при котором начинает преобладать андроидный тип ожирения, наступает приблизительно на два десятилетия позже у женщин, чем у мужчин.…”

Section: циркадные ритмы углеводного обмена при патологии ожирениеunclassified

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Circadian rhythm of carbohydrate metabolism in health and disease

Sorokin

Пинхасов

Selyatitskaya

2023

Acta biomedica scientifica

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The article presents a review of the main circadian mechanisms regulating carbohydrate metabolism and their role in maintenance of energy homeostasis; the molecular genetic structure of the circadian system is also discussed. The role of adipose tissue and other organs and systems in the maintenance of circadian rhythm of carbohydrate metabolism, both in health and in obesity and diabetes, is highlighted. Particular attention is paid to diurnal rhythms of endocrine factors responsible for metabolic patterns of hormones such as cortisol, growth hormone and melatonin. Gender differences in the circadian regulation of energy and carbohydrate metabolism are also discussed, as well as their changes in different age periods. Article provides detailed review of the mechanisms of glucose utilization, reactivity of the pancreatic islets and peripheral insulin sensitivity shifts at different time periods of the day in people with normal body weight, android and gynoid types of obesity, both in women and men. Protective factors of energy metabolism circadian regulation structure preventing the development of diabetes mellitus and cardiovascular disease in individuals with so-called “metabolically healthy” obesity type are discussed. Article provides a review of various pathways of circadian rhythm disturbances, mechanisms of their development, as well as exogenous and endogenous factors leading to carbohydrate metabolic circadian rhythm misalignment, such as shift work, untiming of natural and artificial lighting, jet lags, sleep disorders. Represented data contribute to a new look at the pathogenesis of obesity and carbohydrate metabolism disorders in various types of obesity in men and women, that provides basis for searching for new effective methods of prevention and treatment of these conditions, elaboration of evidence-based diets and physical activity recommendations, as well as approaches to their medical treatment.

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Section: циркадные ритмы углеводного обмена при патологии ожирениеunclassified

Circadian rhythm of carbohydrate metabolism in health and disease

Sorokin

Пинхасов

Selyatitskaya

2023

Acta biomedica scientifica

Self Cite

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“…We have previously shown that men and women with android and gynoid obesity have different frequencies of metabolic syndrome (MS) and its components with significantly higher frequency for android obesity (5,6,7). Men and women with gynoid obesity had no hyperglycemia (MS component), and the risk of insulin resistance, and T2DM was therefore minimal (5).…”

Section: Introductionmentioning

confidence: 99%

Hormonal Regulation of Carbohydrate and Fat Metabolism in Women with Different Obesity Types in the Food Deprivation Test

et al. 2019

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Context. The dominant type of adipose tissue accumulation in the body is associated with the peculiarities of using key substrates in energy metabolism and their hormonal regulation. Hormonal and metabolic parameters were investigated in women with android and gynoid obesity before and after the short-term food deprivation test.Results. At baseline, at gynoid obesity as compared to android obesity, the women's blood contained lower glucose and insulin levels and higher FFA levels. The reaction to food deprivation manifested by a decrease in glucose level and an increase in FFA level in the blood is less pronounced in women with gynoid obesity than in those with android obesity. At the same time, a similar (though varying in expression) decrease in insulin level and elevated levels of glucagon, growth hormone and thyroxine were revealed in women's blood in both groups. Blood cortisol level increased in women with gynoid obesity and remained unchanged in those with android obesity.Conclusions. More pronounced activation of hormonal mechanisms for maintaining blood glucose levels at gynoid obesity as compared to android one suggests that glucose is the preferable substrate for energy metabolism at gynoid obesity in women.

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