Age-changes in right ventricular function–pulmonary circulation coupling: from pediatric to adult stage in 1899 healthy subjects. The RIGHT Heart International NETwork (RIGHT-NET)

Vriz, Olga; Veldman, Gruschen; Gargani, Luna; Ferrara, Francesco; Frumento, Paolo; D′Alto, Michele; D’Andrea, Antonello; Aldosari, Sarah; Cocchia, Rosangela; Marra, Alberto M.; Ranieri, Brigida; Salzano, Andrea; Stanziola, Anna Agnese; Voilliot, Damien; Ágoston, Gergely; Cademartiri, Filippo; Cittadini, Antonio; Kasprzak, Jarosław D.; Grünig, Ekkehard; Bandera, Francesco; Guazzi, Marco; Rudski, Lawrence; Bossone, Eduardo

doi:10.1007/s10554-021-02330-z

Cited by 12 publications

(17 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, the TASPE/SPAP ratio was calculated slightly lower in male elite athletes of both age groups compared to the published age-specific reference values [20]. Interestingly, we also observed higher values for the TAPSE/ SPAP ratio in the older age group (30-39 years), which was mainly attributed to a significantly lower SPAP, as in the reference population [20]. Notably, these non-invasively derived TAPSE/SPAP ratio corresponded well with the invasive measurements reported by Buchan et al [30], suggesting an augmented cardiovascular functional response in highly trained male athletes that ensures an optimal coupling of both the pulmonary and systemic circulation.…”

Section: Discussioncontrasting

confidence: 67%

“…Hence, assessment of TAPSE/SPAP should be undertaken under similar conditions. In the study of Vriz et al [20] and our own study, TAPSE/SPAP was determined under resting conditions with a normal brachial blood pressure. Pre-participation screenings are usually scheduled at the beginning of the competitive season, offering an opportunity to evaluate the morphology and function of the right ventricle and measure the pulmonary circulation coupling at rest, without the confounding influences of prior prolonged exercise sessions.…”

Section: Discussionmentioning

confidence: 97%

“…In contrast to the age changes in LV-arterial coupling that are characterized by a proportionally stiffening of both LV and the arterial vascular tree [ 18 , 19 ], a relatively preserved relationship between TAPSE and SPAP was found across different age groups among healthy subjects and respective reference values have been published [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Normative values of non-invasively assessed RV function and pulmonary circulation coupling for pre-participation screening derived from 497 male elite athletes

Bauer

Tello

Kraushaar³

et al. 2022

Clin Res Cardiol

View full text Add to dashboard Cite

Background Reference values for right ventricular function and pulmonary circulation coupling were recently established for the general population. However, normative values for elite athletes are missing, even though exercise-related right ventricular enlargement is frequent in competitive athletes. Methods We examined 497 healthy male elite athletes (age 26.1 ± 5.2 years) of mixed sports with a standardized transthoracic echocardiographic examination. Tricuspid annular plane excursion (TAPSE) and systolic pulmonary artery pressure (SPAP) were measured. Pulmonary circulation coupling was calculated as TAPSE/SPAP ratio. Two age groups were defined (18–29 years and 30–39 years) and associations of clinical parameters with the TAPSE/SPAP ratio were determined and compared for each group. Results Athletes aged 18–29 (n = 349, 23.8 ± 3.5 years) displayed a significantly lower TAPSE/SPAP ratio (1.23 ± 0.3 vs. 1.31 ± 0.33 mm/mmHg, p = 0.039), TAPSE/SPAP to body surface area (BSA) ratio (0.56 ± 0.14 vs. 0.6 ± 0.16 mm*m2/mmHg, p = 0.017), diastolic blood pressure (75.6 ± 7.9 vs. 78.8 ± 10.7 mmHg, p < 0.001), septal wall thickness (10.2 ± 1.1 vs. 10.7 ± 1.1 mm, p = 0.013) and left atrial volume index (27.5 ± 4.5 vs. 30.8 ± 4.1 ml/m2, p < 0.001), but a higher SPAP (24.2 ± 4.5 vs. 23.2 ± 4.4 mmHg, p = 0.035) compared to athletes aged 30–39 (n = 148, 33.1 ± 3.4 years). TAPSE was not different between the age groups. The TAPSE/SPAP ratio was positively correlated with left ventricular stroke volume (r = 0.133, p = 0.018) and training amount per week (r = 0.154, p = 0.001) and negatively correlated with E/E′ lat. (r = −0.152, p = 0.005). Conclusion The reference values for pulmonary circulation coupling determined in this study could be used to interpret and distinguish physiological from pathological cardiac remodeling in male elite athletes.

show abstract

Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Normative values of non-invasively assessed RV function and pulmonary circulation coupling for pre-participation screening derived from 497 male elite athletes

Bauer

Tello

Kraushaar³

et al. 2022

Clin Res Cardiol

View full text Add to dashboard Cite

show abstract

“…Interestingly, Forton et al, in a cohort of adolescents and adults who underwent EDE, found that pulmonary vascular distensibility coefficient α was inversely related to age at rest as well as during exercise [36]. These results confirm the age-related increase in pulmonary artery pressure (positive correlation) [37][38][39].…”

Section: Discussionmentioning

confidence: 73%

Right Heart Pulmonary Circulation Unit Response to Exercise in Patients with Controlled Systemic Arterial Hypertension: Insights from the RIGHT Heart International NETwork (RIGHT-NET)

Vriz

Palatini

Rudski

et al. 2022

JCM

Self Cite

View full text Add to dashboard Cite

Background. Systemic arterial hypertension (HTN) is the main risk factor for the development of heart failure with preserved ejection fraction (HFpEF). The aim of the study was was to assess the trends in PASP, E/E’ and TAPSE during exercise Doppler echocardiography (EDE) in hypertensive (HTN) patients vs. healthy subjects stratified by age. Methods. EDE was performed in 155 hypertensive patients and in 145 healthy subjects (mean age 62 ± 12.0 vs. 54 ± 14.9 years respectively, p < 0.0001). EDE was undertaken on a semi-recumbent cycle ergometer with load increasing by 25 watts every 2 min. Left ventricular (LV) and right ventricular (RV) dimensions, function and hemodynamics were evaluated. Results. Echo-Doppler parameters of LV and RV function were lower, both at rest and at peak exercise in hypertensives, while pulmonary hemodynamics were higher as compared to healthy subjects. The entire cohort was then divided into tertiles of age: at rest, no significant differences were recorded for each age group between hypertensives and normotensives except for E/E’ that was higher in hypertensives. At peak exercise, hypertensives had higher pulmonary artery systolic pressure (PASP) and E/E’ but lower tricuspid annular plane systolic excursion (TAPSE) as age increased, compared to normotensives. Differences in E/E’ and TAPSE between the 2 groups at peak exercise were explained by the interaction between HTN and age even after adjustment for baseline values (p < 0.001 for E/E’, p = 0.011 for TAPSE). At peak exercise, the oldest group of hypertensive patients had a mean E/E’ of 13.0, suggesting a significant increase in LV diastolic pressure combined with increased PASP. Conclusion. Age and HTN have a synergic negative effect on E/E’ and TAPSE at peak exercise in hypertensive subjects.

show abstract

“…A growing body of evidence demonstrates that right ventricular function is the key factor for cardiovascular disease prognosis ( 6 ). Early diagnosis of right ventricular morphology and function changes may help prevent or delay heart failure and cardiovascular death ( 7 ). However, the extent of right ventricular morphology and function change in patients with hypertension with different left ventricular geometric patterns is still disputed.…”

Section: Introductionmentioning

confidence: 99%

The impact of different left ventricular geometric patterns on right ventricular deformation and function in the elderly with hypertension: A two-dimensional speckle tracking and three-dimensional echocardiographic study

Xue

Kang²,

Qin³

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

ObjectiveThis study aimed to evaluate the impact of different left ventricular geometric patterns on right ventricular deformation and function in the elderly with essential hypertension via two-dimensional speckle tracking and three-dimensional echocardiography.MethodsA total of 248 elderly people with essential hypertension were divided into four groups based on the left ventricular mass index (LVMI) and relative wall thickness (RWT): the normal geometric, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy groups. Moreover, 71 participants were recruited as the control group. These participants were examined by two-dimensional speckle tracking and three-dimensional echocardiography to obtain the right ventricular strain parameters, three-dimensional volume, and function parameters.ResultsThe right ventricular strain parameters decreased gradually from the normal geometric group to the concentric hypertrophy group (P < 0.05), and the strain parameters in the concentric remodeling, eccentric hypertrophy, and concentric hypertrophy groups were lower than those in the control and normal geometric groups (P < 0.05). The right ventricular three-dimensional echocardiographic parameters only changed in the eccentric hypertrophy group (P < 0.05) and the concentric hypertrophy group (P < 0.05) in the form of an increase in volume and a decrease in function. Multivariate linear regression analysis showed that the right ventricular free wall longitudinal strain was independently associated with the systolic blood pressure (SBP), LVMI, and RWT (P < 0.05) and was primarily affected by the LVMI (normalized β = 0.637, P < 0.05).ConclusionThe systolic function of the right ventricular myocardium declined in the elderly with essential hypertension due to impaired myocardial mechanics. The right ventricular strain parameters could indicate mechanical damage in the concentric remodeling group earlier than the right ventricular three-dimensional volume and function parameters. The right ventricular free wall longitudinal strain was primarily subject to the LVMI.

show abstract

Age-changes in right ventricular function–pulmonary circulation coupling: from pediatric to adult stage in 1899 healthy subjects. The RIGHT Heart International NETwork (RIGHT-NET)

Cited by 12 publications

References 40 publications

Normative values of non-invasively assessed RV function and pulmonary circulation coupling for pre-participation screening derived from 497 male elite athletes

Normative values of non-invasively assessed RV function and pulmonary circulation coupling for pre-participation screening derived from 497 male elite athletes

Right Heart Pulmonary Circulation Unit Response to Exercise in Patients with Controlled Systemic Arterial Hypertension: Insights from the RIGHT Heart International NETwork (RIGHT-NET)

The impact of different left ventricular geometric patterns on right ventricular deformation and function in the elderly with hypertension: A two-dimensional speckle tracking and three-dimensional echocardiographic study

Contact Info

Product

Resources

About