Age-associated changes in vascular health and its relation with erythropoietin

Abstract

Objectives: Vascular stiffness due to ageing assessed by alteration in mean arterial blood pressure, brachial-ankle and carotid-femoral pulse wave velocity (b-f PWV/c-f PWV) and brachial and ankle arterial stiffness index (ASI). The present study aimed to determine the influence of ageing on vascular health and its relation to oxygen sensing protein that is, erythropoietin (EPO), in both genders (men and women). Materials and Methods: Randomly selected 204 healthy participants involving men and women between 20 and 95 years among the general population of city. The total sample size was split into six groups from Group I to VI, each containing 17 men participants and 17 women participants. We determined PWV [brachial-ankle and carotid-femoral (PWV)] and ASI (brachial ASI and ankle ASI) by using periscope and estimated serum erythropoietin (Epo) by ELISA method and implemented a one-way ANOVA post hoc test for statistical analysis by using SPSS software version 23. Results: Decreased serum EPO with increased vascular parameters such as mean arterial pressure (MAP), PWV and ASI observed in Group 5 and 6 of both genders. Conclusion: We conclude that ageing influences PWV, ASI, MAP and EPO in men and women participants.

The Role of Serum Erythropoietin (EPO) and Vascular Endothelial Growth Factor (VEGF) in Pulse Wave Velocity (PWV) Among Hypertensive Patients: A Cross-Sectional Study

“…Emerging experimental data and data from various clinical studies indicate that EPO and VEGF have a significant role in the cardiovascular system; e.g., VEGF signaling pathway inhibition induces hypertension, EPO therapy results in increased BP, and EPO-induced hematocrit values and erythrocyte mass alter the integrity of vascular smooth muscles, leading to the deregulation of endothelial vasodilatory factors [ 4 , 5 , 6 ]. The relationship between EPO and VEGF levels and vascular stress has not been fully explored.…”

Vascular physiology: A bridge between health and disease

“…Altered vascular physiology mainly leads to arterial stiffness, commonly associated with ageing. [2] The changes in vascular physiology lead to vascular pathophysiology, which is principally based on haemodynamic principles. Vascular pathophysiology is mainly associated with changes in arterial integrity which may be either arterial wall thickness pathology or luminal diameter alterations with blocks, clots or foam cell formations with increased arterial resistance (R).…”