Vascular physiology: A bridge between health and disease

Das, Kusal K.

doi:10.25259/ijpp_414_2022

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…Oxidative stress parameters in the case of stage II and stage I hypertensive patients were found to be remarkably altered in our findings. Increased MDA in both stage I and stage II HTN indicate altered vascular pathophysiology [ 7 ]. Excessive MDA in stage II and stage I HTN in our study may be due to the generation of more ROS, which is a key factor of HTN pathology by modulating the vasomotor system and developing vasoconstriction through angiotensin II.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, oxidative stress induces endothelial cell apoptosis and senescence, impairing endothelial repair mechanisms and exacerbating vascular injury. Moreover, ROS-mediated oxidative modification of lipids, proteins, and DNA contributes to endothelial dysfunction by disrupting cellular signalling pathways and promoting a pro-inflammatory and pro-thrombotic vascular milieu [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…The serum samples of the first 10 participants which were collected on the first day were stored for 16 days and on the last day serum samples for seven participants were stored for two days. On the 19th day, all the samples were kept at room temperature and assessed for serum MDA and serum NO by using a UV spectrophotometer at 535 nm [ 7 ].…”

Section: Methodsmentioning

confidence: 99%

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Unravelling the Intricate Relationship Between Oxidative Stress and Endothelial Dysfunction in Hypertension

Sharma,

Patil,

Dasgupta

et al. 2024

Cureus

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Introduction: Hypertension (HTN), a leading risk factor for cardiovascular diseases, is intricately linked with endothelial dysfunction, a hallmark of vascular pathology. The effect of oxidative stress in maintaining the optimum endothelial function in the regulation of blood pressure is yet to be explored. While numerous factors contribute to the pathogenesis of HTN, emerging evidence highlights the pivotal role of oxidative stress in endothelial dysfunction, offering novel insights into the underlying mechanisms.Aim: Our study delves into the multifaceted relationship between oxidative stress and endothelial dysfunction in HTN, elucidating key molecular pathways and potential therapeutic avenues. Our study aims to find out the association between oxidative stress and endothelial function in the regulation of blood pressure.Methods: A total of 108 age-matched participants of both genders were divided into three groups by following the guidelines of the American Heart Association (AHA) classification for HTN. Blood pressure was recorded manually in resting posture three times at an interval of 10 minutes using a sphygmomanometer after providing 10 minutes of rest before the first reading. Parameters of oxidative stress and endothelial function were measured by using a UV spectrophotometer. Our study results were depicted as mean ± SD.Results: The correlation between our variables was performed using Spearman's correlation considering the value of p<0.05 as statistically significant. Serum malondialdehyde (MDA), a parameter of oxidative stress, was found to be increasing and serum nitric oxide (NO), a parameter to assess endothelial function, was found to be decreasing as the blood pressure increased. These observations are indicative that optimal oxidative stress and optimal endothelial function are required to maintain normal blood pressure regardless of gender.Conclusions: All persons who are suspected of future cardiovascular risks should be regularly checked for these parameters to avoid cardiovascular morbidity such as HTN.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Unravelling the Intricate Relationship Between Oxidative Stress and Endothelial Dysfunction in Hypertension

Sharma,

Patil,

Dasgupta

et al. 2024

Cureus

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“…The results indicate impairment of vascular integrity compared to controls. Increased PWV also indicates stiffness of conduit arteries, which is a risk factor for CVD [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Serum Erythropoietin (EPO) and Vascular Endothelial Growth Factor (VEGF) in Pulse Wave Velocity (PWV) Among Hypertensive Patients: A Cross-Sectional Study

Patil,

Khodnapur,

Das

et al. 2024

Cureus

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Background and objective While hypertension (HTN) is a major health-related threat globally, it is often an under-reported clinical condition as most of the stage I hypertensive patients do not present with any symptoms. The relationship between endogenous oxygen-sensing protein [erythropoietin (EPO) and vascular endothelial growth factor (VEGF)] levels and vascular stress in hypertensive patients is not fully understood as the mechanistic pathway by which these oxygen-sensing proteins alter the vascular physiology and cause hypertension is still a matter of debate. In light of this, we explored the role of these two proteins in the development of vascular stress including increased pulse wave velocity (PWV). We aimed to examine the correlation between oxygen-sensing proteins and vascular stress markers including PWV in hypertensive patients. Materials and methods We conducted a cross-sectional study involving age-matched participants classified into three groups (group 1: normotensive persons, n=36; group 2: stage I hypertensive patients, n=36; and group 3, stage II hypertensive patients, n=36). Adiposity-related parameters such as waist circumference (WC), hip circumference (HC), BMI, and waist-hip ratio (WHR) were measured. BP was recorded manually in resting posture by using a sphygmomanometer. PWV, which predicts the progression of BP and the development of HTN, was recorded using a periscope, which works based on the oscillometric method. Vascular stress-induced oxidative stress parameters [serum malondialdehyde (MDA) and serum nitric oxide (NO)] were also estimated by using a UV spectrophotometer. Quantitative estimations of oxygen-sensing proteins (serum EPO and serum VEGF) were done by using the ELISA kit method. The results were expressed as mean ± standard deviation (SD). The correlation between the variables was done using Spearman’s correlation. A p-value <0.05 was considered statistically significant. Results Adiposity indices and vascular stiffness parameters were found to be significantly (p <0.05) increased in group 2 and group 3 compared to group 1. The levels of serum MDA were found to be significantly (p<0.05) increased in group 2 and group 3 than group 1, whereas the levels of serum NO were significantly (p<0.05) decreased in group 3 and group 2 than group 1. A significant (p<0.05) positive correlation was observed between the PWV and EPO (r=0.492) while a significant (p<0.05) negative correlation was observed between PWV and VEGF (r=-0.406) among the study population. Conclusion The results are indicative of the influence of vascular stress in stage I and II hypertensive patients. Furthermore, the relationship between oxygen-sensing proteins and vascular stress in hypertensive patients has also been established.

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“…The circulatory system, also referred to as the cardiovascular system, plays a vital role in maintaining physiological functions in all tissues. It is involved in distributing oxygen and nutrients to living cells, regulating body temperature, and eliminating biological waste products from the organism [ 1 ]. Disruption of circulation, which often accompanies various cardiovascular disorders, leads to reduced oxygen delivery, resulting in hypoxia and tissue dysfunction [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Diosmin on Selected Parameters of Oxygen Homeostasis

Feldo,

Wójciak,

Dresler

et al. 2023

IJMS

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Chronic venous disease (CVD) is a condition characterized by functional disturbances in the microcirculation of the superficial and deep veins, affecting up to 30% of the global population. Diosmin, a phlebotropic drug, is commonly used in the treatment of CVD, and its beneficial effects have been described in numerous clinical studies. However, the precise molecular mechanism underlying the activity of diosmin is not yet fully understood. Therefore, the objective of our study was to investigate whether diosmin has an impact on oxygen management, as cardiovascular diseases are often associated with hypoxia. In our study, patients were administered a daily dosage of 2 × 600 mg of diosmin for 3 months, and we evaluated several factors associated with oxygen management, angiogenesis, and inflammation using biochemical assays. Our findings indicate that diosmin reduced the levels of fibroblast growth factors (FGF) and vascular endothelial growth factor (VEGF-C), while increasing endostatin and angiostatin levels, suggesting a potential influence on angiogenesis regulation. Furthermore, diosmin exhibited anti-inflammatory properties by suppressing the levels of tumor necrosis factor-alpha (TNF-α), interleukin 1-beta (IL-1β), and interleukin 6 (IL-6), while promoting the production of interleukin 12 (IL-12). Additionally, diosmin significantly decreased the levels of hypoxia-inducible factor (HIF), anion gap (AG), and lactate, indicating its potential influence on the hypoxia-inducible factor pathway. These findings suggest that diosmin may play a crucial role in modulating oxygen management and inflammation in the context of chronic venous disease.

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Vascular physiology: A bridge between health and disease

Cited by 4 publications

References 8 publications

Unravelling the Intricate Relationship Between Oxidative Stress and Endothelial Dysfunction in Hypertension

Unravelling the Intricate Relationship Between Oxidative Stress and Endothelial Dysfunction in Hypertension

The Role of Serum Erythropoietin (EPO) and Vascular Endothelial Growth Factor (VEGF) in Pulse Wave Velocity (PWV) Among Hypertensive Patients: A Cross-Sectional Study

Effect of Diosmin on Selected Parameters of Oxygen Homeostasis

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