Age as Risk Factor for <i><scp>H</scp>elicobacter pylori</i> Recurrence in Children in <scp>V</scp>ietnam

Nguyen, Thi Viet Ha; Bengtsson, Carina; Nguyễn, Gia Khánh; Yin, Li; Hoang, Thi Thu Ha; Phung, Dac Cam; Sörberg, Mikael; Granström, Marta

doi:10.1111/j.1523-5378.2012.00968.x

Cited by 12 publications

(4 citation statements)

References 18 publications

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“…Only 2 of 46 children older than 5 years became reinfected compared with 4 of 6 children younger than 5 years. In their recent study on the risks for H pylori recurrence, Nguyen et al 32 found that young age was the most prominent independent risk factor for H pylori recurrence: adjusted hazard ratio among children aged 3 to 4, 5 to 6, and 7 to 8 years, relative to those aged 9 to 15 years, were, respectively, 14.3 (95% CI = 3.8-53.7), 5.4 (95% CI = 1.8-16.3), and 2.6 (95% CI = 0.7-10.4). The young age risk factor for reinfection was not found in the study by Feydt-Schmidt et al 33 Our study results showed a trend for better success rates in older age; nevertheless, this has not reached a statistical significance.…”

Section: Discussionmentioning

confidence: 99%

Impact of Age, Gender, and Addition of Probiotics on Treatment Success for Helicobacter pylori in Children

Weiner

Shaoul

2015

Global Pediatric Health

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The primary objective of this study was to evaluate the effect of age, gender, and the use of probiotics with standard treatment regimen on Helicobacter pylori eradication. Based on endoscopic findings and clinical presentation, selected patients were treated with standard triple therapy (omeprazole, clarithromycin, and amoxicillin). Those who failed were offered a repeat treatment with omeprazole, metronidazole, and amoxicillin. After the publications of the possible advantages of probiotic treatment on H pylori eradication, the probiotic agent “Probiotica Forte” was routinely added to the treatment. Eradication was noted for 94/130 patients (72%) and for 128/197 patients (65%) with or without probiotic agent, respectively (P = .23). For second-line treatment eradication was noted in 33/46 (72%) and in 9/20 (45%) with or without probiotic agent, respectively (P = .053). The addition of probiotics may improve eradication success especially in addition to second-line treatment.

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Section: Discussionmentioning

confidence: 99%

Impact of Age, Gender, and Addition of Probiotics on Treatment Success for Helicobacter pylori in Children

Weiner

Shaoul

2015

Global Pediatric Health

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“…Proton pump inhibitor use on a regular basis can potentially alter the outcome of an H. pylori test. Additionally, lack of interest in eliminating H. pylori and an increase in the infection's resistance to eradication due to old age are two additional potential explanations 23 .…”

Section: Discussionmentioning

confidence: 99%

Retrospective study on endoscopic findings of gastritis in children attending the gastrointestinal tract endoscopic unit of Assiut University Children Hospital over a 15-year-period

Abu Faddan,

Reyad,

Shalaby

2023

Sri Lanka J Child Health

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Background: Children with gastritis typically exhibit recurrent stomach pain and dyspepsia or vomiting.Objectives: To assess the frequency, clinical manifestations, endoscopic pictures, aetiology and outcome of gastritis in children who visited the gastrointestinal tract (GIT) endoscopic unit of Assiut University Children Hospital.Method: This was a retrospective, crosssectional study conducted at Assiut University Children Hospital GIT Endoscopic Unit from 1st January 2005 to 31st December 2019.Results: Upper GI endoscopy, done in all cases, showed that 66 (8.1%) had erythematous gastric mucosa, 106 (13%) had nodular gastric mucosa, 212 (25.9%) had erythematous gastric mucosa and hyperaemia, 147 (18%) had erythematous gastric mucosa and nodularity, 156 (19.1%) had hyperaemic mucosa and petechiae, 77 (9.5%) had hyperaemic mucosa and erosion, and 53 (6.5%) had multiple erosions and ulcers.Conclusions: Gastritis represented 9.4% of children who underwent upper GI endoscopy. Helicobacter pylori was the commonest cause with high recurrence. Patients presented with recurrent GI bleeding, and those with erythematous hyperaemic mucosa on endoscopy showed recurrence compared to their counterparts.

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“…Recurrence rates are known to be high in young children or adults with intellectual disability in some previous studies. [353637] This may represent the importance of compliance in terms of maintaining successful eradication status. Lastly, elderly people tend to lack the idea of hygiene and maintain traditional eating habits in Korea.…”

Section: Discussionmentioning

confidence: 99%

Rate and predictive factors of Helicobacter pylori recurrence: Analysis of a screening cohort

Nam

Ryu

Park

et al. 2019

Saudi J Gastroenterol

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Background/Aim: The aim of the study was to identify the recurrence rate of Helicobacter pylori after successful eradication in an endemic area and investigate baseline and clinical factors related to the recurrence. Patients and Methods: H. pylori infected patients from a screening cohort of National Cancer Center between 2007 and 2012 were enrolled in the study. A total of 647 patients who were confirmed to be successfully eradicated were annually followed by screening endoscopy and rapid urease test. Median follow-up interval was 42 months. Annual recurrence rate of H. pylori was identified. Demographics, clinical factors, and endoscopic findings were compared between H. pylori recurrence group and persistently eradicated group (control group). Results: H. pylori recurrence was observed in 21 (3.25%) patients. Its annual recurrence rate was 0.91% (1.1% in males and 0.59% in females). Mean age was higher in the recurrence group than that in the control group (55.9 vs 50.7, P = 0.006). Median follow-up was shorter in the recurrence group than that in the control group (34 vs. 42.5 months, P = 0.031). In multivariate analysis, OR for H. pylori recurrence was 1.08 per each increase in age ( P = 0.012). Adjusted ORs for H. pylori recurrence were 0.20 (95% CI: 0.06–0.69) and 0.25 (95% CI: 0.08–0.76) in age groups of 50–59 years and less than 50 years, respectively, compared to the group aged 60 years or older. Conclusion: H. pylori recurrence rate in Korea is very low after successful eradication. Advanced age is at increased risk for H. pylori recurrence. Thus, H. pylori treatment for patients who are under 60 years of age is more effective, leading to maintenance of successful eradication status.

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Age as Risk Factor for Helicobacter pylori Recurrence in Children in Vietnam

Cited by 12 publications

References 18 publications

Impact of Age, Gender, and Addition of Probiotics on Treatment Success for Helicobacter pylori in Children

Impact of Age, Gender, and Addition of Probiotics on Treatment Success for Helicobacter pylori in Children

Retrospective study on endoscopic findings of gastritis in children attending the gastrointestinal tract endoscopic unit of Assiut University Children Hospital over a 15-year-period

Rate and predictive factors of Helicobacter pylori recurrence: Analysis of a screening cohort

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