Age and Sex-Related Differences in Dental Pulp Stem Cells

Chu, Rene

doi:10.17077/etd.80r5ugyv

Cited by 1 publication

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“…Like others, DP tissue undergoes age‐depended changes and the decline of its regenerative capacity might be related to stem cell senescence (Chu, ). Up to now, few and conflicting data are available on possible age‐related changes in the regenerative potential of DPSCs (Chu, ; Yi et al, ). These cells possess a great self‐expansion and differentiation capabilities toward osteogenic (Teti et al, ), odontogenic (Gronthos et al, ) and neurogenic (Gervois et al, ) phenotypes, making them an interesting cell source for regenerating pulp and periodontal tissues, and in the treatment of neurodegenerative diseases.…”

Section: Discussionmentioning

confidence: 90%

“…Hence, the concept of customized therapies must meet this contingency. Like others, DP tissue undergoes age-depended changes and the decline of its regenerative capacity might be related to stem cell senescence (Chu, 2013). Up to now, few and conflicting data are available on possible age-related changes in the regenerative potential of DPSCs (Chu, 2013;Yi et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Dental pulp stem cells senescence and regenerative potential relationship

Iezzi

Cerqueni

Licini

et al. 2018

Journal Cellular Physiology

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Uncomplicated treatments for pulpitis and periodontitis continues to be challenging and regenerative approaches could meet this contingency. Dental pulp stem cells (DPSCs) represent a good candidate for oral recovering therapies. Here, we investigated changes in morphology, proliferation, and in vitro differentiation toward mesenchymal and neuronal phenotypes of human DPSCs harvested from differently aged donors. Aging is a physiologic phenomenon occurring with time that hamper body's capability to maintain homeostasis also affecting the functional reserve. Cytofluorimetric, immunohistochemical, quantitative reverse-transcription polymerase chain reaction (qRT-PCR), and western blot analyses were performed to gain insight for successful regenerative strategies in elderly.We observed a decline in DPSCs proliferation and differentiation potential with age.Interestingly, these cells behaved differently under osteogenic or odontogenic stimuli, showing different age-related mineralization capabilities. Similarly, neurogenic differentiation decreased with age. In conclusion, our observations represent a valid tool for the development of tailored regenerative strategies in an aging society. K E Y W O R D Saging, DMP1, DPSCs, nestin, p16 ink4a , SA-β-Gal

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