Age and prognosis in stage Ib squamous cell carcinoma of the uterine cervix

Gynning, Inge; Johnsson, J. E.; Alm, Per; Tropé, Claes G.

doi:10.1016/0090-8258(83)90112-9

Cited by 38 publications

(7 citation statements)

References 27 publications

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“…Controversies on the age factor in the literature have been reported [3-5, 29, 31], in which either young patients aged !35 [3,5] or !30 [31] or aged 640 [34] or old patients aged 170 [34] were found to be at poor risk, but many reports disregard age as a true factor [30,35].…”

Section: Discussionmentioning

confidence: 99%

“…This type of operation has resulted in reports of recurrence rates of 10-40% and 5-year survival rates ranging from 72.1 to 90.3% [2]. In cervical carcinoma, prognosis appears to depend upon the presence of important clinicopathological factors, including para-aortic or pelvic lymph node (LN) metastases, bulky tumor size, deep stromal invasion (DSI), lymph-vascular space involvement (LVSI), parametrial invasion, pathological type, DNA index, and HPV DNA or HPV-16 DNA [3][4][5][6][7][8][9][10][11][12]. However, many factors are still controversial in their prognostic significance including the patient's age [3][4][5], tumor size [6][7][8], keratinized type [4][5][6][7], cell type [7,9,10], and clinical stage [7,11].…”

Section: Introductionmentioning

confidence: 99%

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Recurrence and Survival Analyses of 1,115 Cervical Cancer Patients Treated with Radical Hysterectomy

Yuan¹,

Wang²,

Lai

et al. 1999

Gynecol Obstet Invest

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Many clinicopathological factors of cervical cancer are still controversial in their prognostic significance. The case records of 1,115 patients who received radical hysterectomy at the Veterans General Hospital, Taipei, from 1980 to 1989 were collected to evaluate prognosis-related factors by univariate and multivariate analyses. The pathology was reviewed retrospectively by one pathologist. Ten parameters known to be prognostic in the literature were included for analysis. Univariate analysis showed that patients with all these factors had higher recurrence rates. However, when the effects of parametrial invasion, progressive stage and stromal invasion were weighed against the presence of lymph node metastasis, their influence on recurrence became unimportant. Nevertheless, these factors still influenced prognosis when there was no lymph node metastasis. Multivariate analysis of both recurrence and survival time in the patients with squamous cell carcinoma shared a consensus that pelvic lymph node metastasis and deep stromal invasion were significant risk factors. We conclude that these simplified and consistent results obtained by multivariate analysis provide a basis for subclassification of patients to predict prognosis and change therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recurrence and Survival Analyses of 1,115 Cervical Cancer Patients Treated with Radical Hysterectomy

Yuan¹,

Wang²,

Lai

et al. 1999

Gynecol Obstet Invest

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“…A substantial increase in preinvasive and invasive carcinoma of the cervix has been reported in women under 35 years of age in the past 20 years (1)(2)(3)(4)(5)(6)(7)(8). There is a strong correlation between the presence of HPV infection and cervical dysplasia, an association having been made between the presence of HPV types 16, 18, 3 1, and 33 and the development of high-grade intraepithelial and invasive malignant lesions of the cervix ( 9).…”

Section: Introductionmentioning

confidence: 99%

Uterine cervical punch biopsy specimens can be analyzed by ¹h mrs

Mountford

Delikatny

Dyne

et al. 1990

Magnetic Resonance in Med

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Biopsy specimens of the uterine cervix, including colposcopically directed punch biopsy specimens of females with atypical Papanicolaou smear tests, are suitable for analysis by magnetic resonance (MR) spectroscopy. A narrow lined lipid MR spectrum, characteristic of malignant tissue, is obtained from a 6-mm3 biopsy specimen of histologically confirmed squamous carcinoma of the cervix. In contrast, specimens containing inflammatory cells generate a broad component only centered at 1.3 ppm with a T2 relaxation value of less than 350 ms. Most biopsy specimens which contain dysplastic cells or evidence of human papilloma virus (HPV) infection have a discernible lipid spectrum similar to that of the malignant tissue specimen. Long T2 relaxation values found in malignant tissue specimens at 1.3 and 1.2 ppm are observed in some but not all of the biopsies which show evidence of HPV infection. The suitability of small tissue samples, such as punch biopsy specimens, for study by MR illustrates the sensitivity of this technique and its potential as an aid to histopathological discrimination between the various precursor states of cervical cancer.

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“…Several authors have reported that invasive carcinoma of the cervix had a poorer prognosis in younger patients than in older ones [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Others found no effect of age [15][16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Younger age as a bad prognostic factor in patients with carcinoma of the cervix

Jf¹,

Pampallona²,

Coucke³

et al. 1996

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: To verify the influence of age on the prognosis of cervix carcinoma. Study design: Five hundred and sixty eight patients treated for a FIGO stage IB-IVA with radical irradiation in the Centre Hospitalier Universitaire Vaudois of Lausanne were subdivided according to the following age categories: _<45, 46-60, 61-69 and > 70 years. Taking the 46-60 years age group as the reference, the hazard ratios (HR) of death and corresponding 95% confidence intervals (95% CI) were estimated by means of a Cox multivariate analysis. Results: The 5-year survival rates were, respectively, 57%, 67%, 60% and 45%. For the youngest women the risk of death was significantly increased (HR = 2.00, 95% CI [1.32-3.00]) and was even more accentuated in advanced stages. Conclusion: Age under 45 years is a bad prognostic factor in carcinoma of the cervix.

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Age and prognosis in stage Ib squamous cell carcinoma of the uterine cervix

Cited by 38 publications

References 27 publications

Recurrence and Survival Analyses of 1,115 Cervical Cancer Patients Treated with Radical Hysterectomy

Recurrence and Survival Analyses of 1,115 Cervical Cancer Patients Treated with Radical Hysterectomy

Uterine cervical punch biopsy specimens can be analyzed by ¹h mrs

Younger age as a bad prognostic factor in patients with carcinoma of the cervix

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Age and prognosis in stage Ib squamous cell carcinoma of the uterine cervix

Cited by 38 publications

References 27 publications

Recurrence and Survival Analyses of 1,115 Cervical Cancer Patients Treated with Radical Hysterectomy

Recurrence and Survival Analyses of 1,115 Cervical Cancer Patients Treated with Radical Hysterectomy

Uterine cervical punch biopsy specimens can be analyzed by 1h mrs

Younger age as a bad prognostic factor in patients with carcinoma of the cervix

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Product

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Uterine cervical punch biopsy specimens can be analyzed by ¹h mrs