Age and Gender Peculiarities of Development of Gallstone Disease

Хохлачева, Н. А.; Sergeeva, N. N.; Вахрушев, Я. М.

doi:10.20514/2226-6704-2016-6-1-34-39

Cited by 7 publications

(7 citation statements)

References 3 publications

(4 reference statements)

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“…Based on this study, the most age occurred at the age above 40 years. This is in accordance with previous studies where most occur at the age of over 50 years (Hohlacheva, Sergeeva and Vahrushev, 2016). Based on this study, it was found that stones were most common in women, this is in accordance with previous studies (Kuy et al, 2013;Ahmad et al, 2015).…”

Section: Discussionsupporting

confidence: 93%

Relationship Of Gallstone Types And Bile Microorganism Infection In Gallstone Patients In H. Adam Malik Hospital And Network Hospital

Nasution¹,

Asrul²,

Muhar³

et al. 2021

IJSRP

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Introduction: The prevalence of gallstones varies between the population in each country and the ethnicity of the country. Incidence is reported in 11-36% of the world's population, 10% in the population of Western countries. In developing countries the prevalence varies from 15-25%. Research on the analysis of the bile acid composition of the microbiota shows the role of bacteria in the formation of pigment stones. From several patients after cholecystectomy, infection and sepsis occurred, the patient's bile culture -bacteria were found. Methods: To analyze the type of gallstones macroscopically with culture to see the presence or absence of infection with microorganisms in bile. patients with cholelithiasis or gallstones at HAM Hospital and Network Hospital. Results: In this study several results were found, namely stones occur mostly at the age of over 40 years, occur more in women, cholesterol stones are the most stones, on examination of bacteria more are negative, in samples with germs found Klebsiella pneumoniae the most and Enterococcus faecalis the least, the number of cholesterol and pigment stones is the same in proportion for the age group under 40 years. it was found that there was a relationship (p<0.05) between the type of stone and the lab results. Conclusion: In this study, female patients generally had positive stones and males were more dominantly negative, and the type of stone had a relationship with the microorganism lab results.

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Section: Discussionsupporting

confidence: 93%

Relationship Of Gallstone Types And Bile Microorganism Infection In Gallstone Patients In H. Adam Malik Hospital And Network Hospital

Nasution¹,

Asrul²,

Muhar³

et al. 2021

IJSRP

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“…In accordance with the classification of GSD by the Russian Gastroenterologists Association (2003), biliary sludge is an early manifestation of the disease, which is noted in its first (initial) stage (Hohlacheva et al, 2016). Therefore, in most cases, in the presence of biliary sludge, a drug correction is required, for example with UDCA preparations.…”

Section: Efficiency and Safety Studiesmentioning

confidence: 88%

Promising new fixed combination for the treatment of diseases of the hepatobiliar system: Substantiation of pharmacotherapeutic properties and pharmaceutical quality profile

Bondarenko

Горчакова

Golembiovska³

et al. 2018

Regul. Mech. Biosyst.

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In this review article an analysis of literature data on the pharmacological and clinical study of a fixed combination of medicinal substances (artichoke leaf extract, ursodeoxycholic acid, taurine, and Angelica sinensis roots extract), as well a scientific substantiation of the pharmaceutical quality profile of the corresponding finished solid dosage form has been conducted. Chronic diseases of the hepatobiliary system are some of the most common human diseases and inferior only to atherosclerosis . The fact that cholecystectomy is the most common surgical operation in the abdominal organs is evidenced by the widespread distribution of the pathology of the biliary system. The fact that there is an increasing number of diagnoses of cholelithiasis in children and infants is a cause for concern. Diseases of the biliary system are closely related to violations of the functional state of the liver. Synthesis of cholesterol supplemented bile with reduced bile acid content significantly increases the risk of gallstones, as well as gallbladder cholesterol. We have substantiated that the developed preparation is a fixed combination of medicinal substances with well-researched medical applications in the treatment of dyspeptic disorders with functional disorders of the biliary system, biliary dyskinesia of the hypokinetic type, and gastritis with reflux of bile. Each of the components of the fixed combination has an important influence on the human hepatobiliary system. The effect of ursodeoxycholic acid is due to the relative replacement of lipophilic toxic bile acids, improving the secretory capacity of hepatocytes and immunoregulatory processes, which is especially important in liver and cholestatic diseases. Taurine is a synergist of ursodeoxycholic acid, since it forms biliary conjugates in the liver. The artichoke extract has choleretic, hepatoprotective and diuretic effects, while the A. sinensis roots extract demonstrates moderate spasmolytic and anti-inflammatory properties. We conducted a general description of active pharmaceutical ingredients and a review of biopharmaceutical tests, analyzed relevant pharmacokinetic and pharmacodynamic studies, and summarized the results of clinical efficacy and safety trials. Particular attention is paid to the results of clinical studies of the developed fixed combination. It should be noted that artichoke leaf extract, ursodeoxycholic acid, and taurine are widely used throughout the world in official medicine, at the same time, A. sinensis roots extract is more widely used in traditional Chinese medicine. The fixed combination has a favorable safety profile, is investigated in clinical conditions in vivo both in the form of individual components and in the form of a single drug. A fixed combination pharmaceutical profile is based on the general requirements for solid dosage forms, as well as experimentally substantiated specific indicators and research methods.

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“…В желчи определялась суммарная концентрация желчных кислот -ЖК ж, холестерина -ХС ж [9], вычислялся индекс литогенности желчи -холатохолестериноввй коэффициент (ХХК ж) . По методике, разработанной для слюны [10] На ранней стадии ЖКБ у молодых людей метаболизм экзогенного холестерина происходит медленнее, у пожилых -снижается активность 7-альфа-гидроксалазы, участвующей в синтезе желчных кислот из холестерина [11,12]. Нами получены аналогичные данные: в 1-й группе литогенность желчи главным образом связана с повышенным уровнем ХСж, в 3-й группе -со сниженным уровнем ЖКж, во 2-й группе -эти процессы относительно уравновешены.…”

Section: материал и методыunclassified

Diagnosis of promicrolithic changes in gallbladder bile by crystallography

Вахрушев

Хохлачева

Глазырина

et al. 2021

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The aim of the study. Determining the dependence of the bile microstructure degree of destabilization of bile and on the age of patients with the I (pre-stone) stage of the cholelitiasis.Material and methods. About 396 patients with stage I of cholelitiasis. 1 group consisted of 125 young patients (25–44 years), 2 groups — 164 middle-aged patients (45–59 years), 3 group — 107 elderly patients (60–74 years). In verifi cation of the diagnosis, in addition to anamnestic and general clinical data, the results of ultrasound examination (ultrasound) of the gallbladder, the study of the physical and chemical properties of bile are used. Crystallography was used to study the morphological pattern of the gallbladder.Results. In the evaluation of the bladder bile of patients with stage I gallstone disease, there is a decrease in the angle of the tilt of the liquid crystal lines, as well as the appearance of optically active inclusions, such as branched dendrites with plate branches, matted- fi ber aggregates, shield- shaped units and short- branched dendrites.Conclusion. Crystallography is highly sensitive, but at the same time an easy-to-perform method and can be widely used in early diagnosis of gallstone disease.

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Age and Gender Peculiarities of Development of Gallstone Disease

Cited by 7 publications

References 3 publications

Relationship Of Gallstone Types And Bile Microorganism Infection In Gallstone Patients In H. Adam Malik Hospital And Network Hospital

Relationship Of Gallstone Types And Bile Microorganism Infection In Gallstone Patients In H. Adam Malik Hospital And Network Hospital

Promising new fixed combination for the treatment of diseases of the hepatobiliar system: Substantiation of pharmacotherapeutic properties and pharmaceutical quality profile

Diagnosis of promicrolithic changes in gallbladder bile by crystallography

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