Age and gender dependent alterations in the activities of glutathione related enzymes in healthy subjects

Habif, Sara; Mutaf, Isil; Turgan, Nevbahar; Onur, Ece; Duman, Can; Özmen, Dilek; Bayındır, Oya

doi:10.1016/s0009-9120(01)00279-x

Cited by 53 publications

(30 citation statements)

References 21 publications

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“…In present study signifi cant differences were not observed in the biological markers of oxidative stress by sex, which is contradictory to several studies (Christensen et al 2001;Habif et al 2001). Gender is a profound determinant of aging and lifespan, however, little is known about gender differences in free radical homeostasis.…”

Section: Discussioncontrasting

confidence: 99%

Aging-Related Oxidative Stress in Healthy Humans

Mendoza-Núñez

Ruíz-Ramos

Sánchez-Rodrı́guez

et al. 2007

Tohoku J. Exp. Med.

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MENDOZA-NÚÑEZ, V.M., RUIZ-RAMOS, M., SÁNCHEZ-RODRÍGUEZ, M.A., RETANA-UGALDE, R. and MUÑOZ-SÁNCHEZ, J.L. Aging-Related Oxidative Stress in Healthy Humans. Tohoku J. Exp. Med., 2007, 213 (3), 261-268 Oxidative stress has been reported to increase with aging; however, the scientifi c evidence is controversial. We therefore aimed to analyze the relationship between aging and some markers of oxidative stress. A crosssectional and comparative study was carried out in a sample of 249 healthy subjects: (i) 25-29 years (n = 22); (ii) 30-39 years (24); (iii) 40-49 years (30); (iv) 50-59 years (48); (v) 60-69 years (60), and (vi) 70 years (65). We measured lipoperoxides and total antioxidant status in plasma and superoxide dismutase and glutathione peroxidase activities in erythrocytes. There was an age-related increase in lipoperoxides, which was evident in the comparison of the group of 25-29 years (0.22 ± 0.11 μ mol/l) with the group of 60-69 years (0.38 ± 0.18 μ mol/l, p < 0.01) and 70 years (0.42 ± 0.19, p < 0.001). Conversely, the total antioxidant status showed an age-related decrease (25-29 years, 1.4 ± 0.31 mmol/l vs 60-69 years, 1.1 ± 0.21 and 70 years, 1.1 ± 0.22, p < 0.05 for each). In erythrocytes, glutathione peroxidase activity showed an age-related decrease (25-29 years, 7,966 ± 1,813 UI/l vs 60-69 years, 6,193 ± 2,235 and 70 years, 6,547 ± 2,307, p < 0.001 for each), whereas superoxide dismutase activity was similar in all age groups. Importantly, there was no age-related change in oxidative stress markers in subjects of < 60 years. These fi ndings suggest that age of 60 years may be associated with increased oxidative stress.aging; oxidative stress; superoxide dismutase; lipoperoxides; antioxidant enzymes

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Section: Discussioncontrasting

confidence: 99%

Aging-Related Oxidative Stress in Healthy Humans

Mendoza-Núñez

Ruíz-Ramos

Sánchez-Rodrı́guez

et al. 2007

Tohoku J. Exp. Med.

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“…GSH content decreases with age in many tissues, whereas it is unclear whether it differs between genders. So far, no gender specific difference in RBC GSH content was found, although 1) estrogen is one of the hormones that regulate GSH homeostasis, and 2) age-and-gender dependent alterations in the activities of glutathione-related enzymes have been observed [24,25]. Our finding of a gender-dependency in RBC GSH content is partially at variance with previous data in mice where no difference was found.…”

Section: Discussioncontrasting

confidence: 72%

Cardiovascular Risk by Gender in an Italian Pilot Study

Matteucci¹,

Giampietro²

2009

VDP

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Part of the international variation in the gender differences in total mortality remains unexplained. Although a continuous decrease in age-standardised death rates was observed in Italy, the difference between male and female rates became relatively small or even reversed (as the rate for ischaemic heart diseases).We performed an extensive evaluation of cardiovascular risk factors -demographic and clinical characteristics, biochemical parameters, and oxidative biomarkers -in a sample of healthy subjects (94 women and 75 men) from Central Italy and analysed their relationship with the response to ergometer exercise.In addition to a proportion of smokers similar to that observed in men, a clustering of peculiar female cardiovascular risk factors emerged. This included: higher platelet counts, low participation in leisure-time aerobic physical activities, hypertensive response to exercise (BMI-dependent, unlike in men), and low fraction of heart rate reserve. Physical inactivity and high serum IL-6 levels were independently predictive of having both chronotropic incompetence and abnormal heart rate recovery.

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“…34 We found no signi¢cant gender di¡erence in serum GPx activities. Similarly, erythrocyte GPx activity has been reported as being either slightly higher 33,35 or no di¡erent 36 in women compared with men.…”

Section: Discussion Effects Of Gender On Trace Element Statusmentioning

confidence: 95%