Age and gender characteristics of blood lipid profile in patients with hypertension and coronary heart disease

Abstract

Cardiovascular disease (CVD) in the 21st century remains the leading cause of death worldwide. In Ukraine, during 2020, 365,515 ukrainians died from heart disease and da­mage of the circulatory system. It is known that hypertension (AH) is one of the most important risk factors for atherosclerosis, accelerates its development and complicates the course, and these two diseases often accompany each other. Especially common is a combination of coronary heart disease (CHD), its various forms (angina, myocardial infarction, arrhythmia) and hypertension. The aim of the study was to establish the age and sex characteristics of the lipid profile of the blood of patients with hypertension and coronary heart disease. Analyzed the statistical data of a survey of 775 people (of which 436 women and 339 men). The data on total cholesterol, triglycerides and high-density lipoprotein cholesterol content for patients with hypertension and coronary disease was analyzed in order to assess the blood lipid spectrum. Statistical analysis and data processing was performed using standard methods of variation Statistics in the Statistics 8.0 software. Changes in lipid metabolism in patients with ischemic heart disease and hypertension were studied. The performed analysis of age-related and gender-related dynamics of blood lipid spectrum parameters – total triglycerides, total cholesterol (CS), low- and high-density lipoprotein cholesterol (LDL cholesterol and HDL cholesterol), the prognostic coefficient of atherogenicity (CA). It was found that the level of total cholesterol in women in the age groups <45 and 55–65 years old is higher than in similar groups in men. In age groups > 65 years, gender difference in total cholesterol levels is not observed. In age group 45–55 years, there are gender-dependent differences in the value of the prognostic coefficient of atherogenicity. For women there were no age-related changes in triglyceride levels. For men there is a depen­dence of the triglyceride’s levels with the age of patients. There were no significant diffe­rences in the levels of low- and high-density lipoproteins depending on gender.