Age and body mass related changes of cardiovascular risk factors in women with polycystic ovary syndrome

Abstract

Polycystic ovary syndrome (PCOS) is considered a metabolic disorder closely related to obesity, insulin resistance (IR), hyperinsulinemia and unfavorable lipid profile, all increasing the risk for the occurrence of cardiovascular diseases. The aim of this study was to assess age and body mass index (BMI) related changes of cardiovascular risk factors in 90 women with PCOS. The cut-off age point was 30 years and for BMI 27.8 kg/m2. In all patients systolic and diastolic blood pressure (BP), metabolic parameters comprising values of glucose and insulin during oral glucose tolerance test (OGTT), and basal lipid values were determined. Significant increase in blood pressure (BP) indices, basal insulin values and insulin resistance (IR) assessed by HOMA model were observed with aging and the increase of BMI, while the parameters of glucose metabolism, total cholesterol and triglycerides were significantly elevated only with aging. However, the correlation between the indices of arterial blood pressure, and lipid and glucose metabolism parameters occurred only in patients over 30 years of age, pointing to the causative relation and the consequent deterioration of IR and lipid profile with aging, influencing cardiovascular function in women with PCOS.

Cross-sectional analysis of the effects of age on the hormonal, metabolic, and ultrasonographic features and the prevalence of the different phenotypes of polycystic ovary syndrome

“…However, it also might suggest that the worsening of IR with aging is more pronounced in women with PCOS than in healthy women. An earlier crosssectional study also reported a worsening of IR in women with PCOS >30 years of age (21). On the other hand, in a prospective study in women with PCOS who showed no increase in BMI, waist circumference, or waist-to-hip ratio during a 10-year follow-up, plasma insulin levels and area under the OGTT curve also remained unchanged (17).…”

Changes in clinical and biochemical characteristics of polycystic ovary syndrome with advancing age

“…A number of reports have shown however, that at baseline insulin levels are higher in PCOS women, mainly after 25 to 30 years of age (18,60). On the other hand, other studies have denied that insulin increases in PCOS over time (4,6,13,19,21,23,62,64,65), particularly in those patients in whom BMI, WC, and WHR remained stable. The baseline concentration of fasting insulin was in fact reported to decrease (17) or remain stable (4,15) during the aging process.…”

“…The baseline concentration of fasting insulin was in fact reported to decrease (17) or remain stable (4,15) during the aging process. It is possible that a decrease in androgens (65) and an increase in fat distribution abnormalities influences insulin levels over time; additionally, different populations, or different study eligibility might explain possible inconsistencies across studies.…”

Etude des aspects cliniques, échographiques et nutritionnels du syndrome des ovaires micropolykystiques (SOMPK) à Mbuji-Mayi, RD du Congo

“…Par rapport à la parité, la proportion des patientes nullipares court un risque de 1,61 fois de contracter ce syndrome. Cette observation corrobore avec les études épidémiologiques qui constatent que les femmes nullipares avec SOMPK sont prédominantes [ 17 , 18 ].…”