Agaricus blazei Murill - immunomodulatory properties and health benefits

Biedroń, Rafał; Tangen, Jon‐Magnus; Maresz, Katarzyna Z.; Hetland, Geir

doi:10.31989/ffhd.v2i11.72

Cited by 20 publications

(18 citation statements)

References 78 publications

(138 reference statements)

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“…However, the presence of Ehrlich tumor did not result in significantly increased levels in animals treated with WB7Poly, WB4Poly, WB4Sn, U7Poly, and U7Sn. Thus, the immunomodulatory activity of fungi described previously (BIEDRON et al, 2012) was partially observed in the present study. …”

Section: Resultssupporting

confidence: 64%

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Serum hepatic biochemistry and electrophoretic protein profile of healthy and Ehrlich tumor-bearing mice treated with extracts of Agaricus blazei Murill

et al. 2016

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Compounds isolated from Agaricus blazei Murill represent a group of promising natural immunomodulators for use in the treatment of neoplasms. We have evaluated the serum biochemical profile of healthy and Ehrlich tumor-bearing mice treated with different extracts of A. blazei. Total, supernatant, and polysaccharide extracts of A. blazei were obtained from suspensions (at acidic or neutral pH) kept in a water bath at 60 °C or in an ultrasonic bath at 37 °C. After oral administering the extracts to mice for 21 days, blood samples were collected for determination of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK), urea, total protein, albumin, globulins, and alpha-, beta-and gamma-globulin fractions. The presence of the tumor led to a significant increase in serum CK and AST activities and in the concentrations of total globulin and the gamma-globulin fraction, and to a decrease in the albumin and alpha2-globulin levels. The polysaccharide extracts of A. blazei reduced the serum AST and ALT activities, probably due to a hepatoprotective effect. In addition, polysaccharide and supernatant extracts inhibited the tumor-induced increase in gamma-globulin levels. Thus, the supernatant and polysaccharide fractions of the extract of A. blazei have potential for use in complementary antineoplastic treatments. Key words: Agaricaceae. Agaricales. Sun mushroom. Extracts. Polysaccharides. Antitumor. saudáveis ou portadores do tumor de Ehrlich tratados com diferentes extratos de A. blazei. Em pH ácido ou neutro e sob temperatura de extração de 60 ºC em banho-maria ou 37 ºC em banho ultrassônico foram obtidos extratos totais, de sobrenadante e de polissacarídeos de A. blazei. Após administração oral dos tratamentos para camundongos por 21 dias foram realizadas coletas de sangue e determinadas as atividades de aspartato aminotransferase (AST), alanina aminotransferase (ALT), creatina quinase (CK) e as concentrações de ureia, proteína total, albumina, globulinas e frações alfa, beta e gamaglobulina. A presença do tumor de Ehrlich foi responsável por aumento significativo nas atividades séricas de AST e CK e das concentrações de globulinas totais e da fração gama-globulina, além de redução dos níveis de albumina e das alfa2-globulinas. Os extratos de polissacarídeos de A. blazei reduziram as atividades séricas de AST e ALT, provavelmente devido a um efeito hepatoprotetor. Além disto, extratos de polissacarídeos e sobrenadante inibiram o aumento das gama-globulinas induzido pelo tumor. Assim, as frações de polissacarídeos e sobrenadante do extrato de A. blazei apresentam bom potencial para uso complementar ao tratamento antineoplásico. Resumo

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Section: Resultssupporting

confidence: 64%

“…Some of the functional compounds from A. blazei are inside the cell wall (FIRENZUOLI et al, 2008;BIEDRON et al, 2012). Therefore, greater disruption of the cells may increase adjuvant activity against cancers by releasing additional compounds.…”

Section: Introductionmentioning

confidence: 99%

Serum hepatic biochemistry and electrophoretic protein profile of healthy and Ehrlich tumor-bearing mice treated with extracts of Agaricus blazei Murill

et al. 2016

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“…AbM is rich in antitumor protein-glucan complexes [17], and β-glucans [18], which are potent stimulators of macrophages [19,20], granulocytes [21], natural killer (NK) cells [22] and DC [23]. The immunomodulatory properties and health effects of AbM have recently been reviewed [24].…”

Section: Introductionmentioning

confidence: 99%

Stimulation of human monocytic cells by the medicinal mushroom Agaricus blazei Murill induces expression of cell surface markers associated with activation and antigen presentation

Tangen¹,

Ama²,

Hetland³

2014

Appl Sci Rep

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Agaricus blazei Murill (AbM) is an edible Bacidiomycota phyllum mushroom used in traditional medicine as a remedy against a wide range of diseases, including infection and cancer. It is rich in β-glucans and antitumor protein-glucan complexes, which have been shown to have stimulating effects on cells involved in innate immunity, such as monocytes, NK cells and dendritic cells. The present report shows that stimulation of monocyte-derived dendritic cells (MDDC) with an AbM-based extract, AndoSan TM , induces modulation of expression of cell surface markers. Incubation of MDDC with 10% of AndoSan TM resulted in upregulation of CD1a, CD14, CD40, CD80, CD83 and CD86, de novo expression of CD69 and downregulation of CD11c expression. The modulation was time dependent. Our investigation shows the ability of AndoSan TM to immunomodulate and activate MDDC in vitro, and agrees with the recent findings of increased production of cytokines and chemokines in AndoSan TM -stimulated MDDC cultures. Furthermore, it is demonstrated that AbM can stimulate human promonocytic THP-1 cells via TLR2 and thus induce activation and migration of transcription factor NF-κB from cytosol to the nucleus. It is therefore probable that binding to TLR2 is a significant mechanism behind AndoSan TM activation of MDDC.

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“…They have been used to treat gastric cancer (lentinan) and head and neck cancer (schizophyllan), in combination with chemotherapy (Ina et al, 2013;Filipa et al, 2017). In addition, other polysaccharides rich in β-1, 3-D-glucans, β-1, 4-D-glucans, β-1, 6-D-glucans, α-1, 4-D-glucans, α-1, 6-D-glucans, and glucomannan have been isolated from A. blazei; these have been shown to have immunomodulatory and antineoplastic properties (Biedron et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies mentioned that most bioactive polysaccharides isolated from mushrooms are branched or unbranched homopolysaccharides (Biedron et al, 2012;Ina et al, 2013;Filipa et al, 2017), which usually contain long chains of glucose polymer. In our study, most of the mushroom extracts were positive with Molisch's test -a general test for detecting carbohydrates, including monosaccharides, disaccharides, and polysaccharides -indicating that the extracts contained carbohydrates.…”

Section: Discussionmentioning

confidence: 99%

Detection of a Non-animal Source of Glycosaminoglycans from Edible Mushrooms in Northern Thailand

Choocheep¹,

Nathip²

2018

CMUJNS

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Several kinds of cultivated or local edible mushrooms exist in northern Thailand. While their nutritional features have been extensively analyzed, the presence of phytochemicals and glycosaminoglycans has yet to be investigated. Thus, in this study, we examined the presence of phytochemicals and glycosaminoglycans from 10 cultivated or local mushrooms: milk white russula, hygroscopic earthstar, log white fungi, log black fungi, shitake mushroom, rosy russula, sajor-caju mushroom, Jew's ear, bolete, and straw mushroom. Phytochemical analysis revealed the presence of carbohydrates, amino acids, and flavonoids in the extracts from most of the mushrooms. We detected glycosaminoglycans in all of the extracts using dimethylmethylene blue (DMMB) dye-binding assay and UVVis spectrophotometry. Hygroscopic earthstar contained the most glycosaminoglycans and sajor-caju mushroom the least. However, we were unable to distinguish the types of glycosaminoglycans, which should be considered for future study. In summary, the phytochemicals found here are crucial non-animal dietary sources of carbohydrates, amino acids, and antioxidants. In addition, the glycosaminoglycans detected in the mushroom extracts in this study potentially offer a non-animal source of glycosaminoglycans that may have clinical applications, apart from their nutritive value.

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Agaricus blazei Murill - immunomodulatory properties and health benefits

Cited by 20 publications

References 78 publications

Serum hepatic biochemistry and electrophoretic protein profile of healthy and Ehrlich tumor-bearing mice treated with extracts of Agaricus blazei Murill

Serum hepatic biochemistry and electrophoretic protein profile of healthy and Ehrlich tumor-bearing mice treated with extracts of Agaricus blazei Murill

Stimulation of human monocytic cells by the medicinal mushroom Agaricus blazei Murill induces expression of cell surface markers associated with activation and antigen presentation

Detection of a Non-animal Source of Glycosaminoglycans from Edible Mushrooms in Northern Thailand

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