AGA Medical Position Statement on the Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease

Farraye, Francis A.; Odze, Robert D.; Eaden, Jayne; Itzkowitz, Steven H.

doi:10.1053/j.gastro.2009.12.037

Cited by 445 publications

(351 citation statements)

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“…Wells without amplification were assigned a cycle threshold (Ct) value of 40. Results were calculated using the ΔΔC t method and expressed as a fold change of the quiescent colitis group as described in the RT 2 Profiler PCR Array Data Analysis (http://www.sabiosciences.com/pcrarraydataanalysis.php). Statistical comparisons between groups were performed using Bioconductor's R statistical program (HTqPCR Bioconductor package; http://www.bioconductor.org/).…”

Section: Methodsmentioning

confidence: 99%

“…More specifically, patients with ulcerative colitis (UC) are at high risk for developing colorectal cancer (2); both extent and duration of intestinal inflammation further increase risk (3,4). These associations suggest that chronic intestinal inflammation is a causative factor in carcinogenesis in patients with UC, and that there is a causal link between chronic inflammation and increased risk of cancer.…”

mentioning

confidence: 97%

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Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer

Gillespie¹,

Leeman²,

Watts³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Patients with chronic ulcerative colitis (UC) are at high risk for developing colorectal cancer. In this study, archival formalin-fixed paraffin-embedded colonic tissue from patients with UC who developed carcinoma (CA) or high-grade dysplasia (HGD) was examined for changes in expression of the proinflammatory and mitogenic neurokinin-1 receptor (NK-1R). Laser capture microscopy was used to microdissect epithelia from areas of colons that showed histologic evidence of CA, HGD, and epithelia that were not dysplastic or cancerous but did contain evidence of prior inflammation (quiescent colitis). mRNA was extracted from the dissected tissue, and PCR array analysis was performed on extracted mRNA. Two antibodies were necessary to separately estimate the protein levels of the truncated (tr-NK-1R) and full-length (fl-NK-1R) receptors by immunohistochemistry. mRNA expression of tr-NK-1R increased 14-fold (P = 0.02) when comparing the HGD and CA groups. In contrast, the fl-NK-1R transcript showed no significant differences among groups. The protein levels of the total NK-1R increased by 40% (P = 0.02) in HGD and 80% (P = 0.0007) in CA compared with quiescent colitis. There were no significant changes in protein levels of the fl-NK-1R. We conclude that the increase in total NK-1R protein in HGD and CA is attributable to an increase in tr-NK-1R, suggesting there may be a functional role for tr-NK-1R in malignant transformation in colitis-associated cancer. The tr-NK-1R could prove useful as a diagnostic marker to identify patients at risk for neoplasia and may serve as a useful therapeutic target in the treatment of colitisassociated cancer.colon cancer | receptor splice variants | substance P | IBD C hronic inflammation is associated with a higher rate of cancer development in various organs (1). More specifically, patients with ulcerative colitis (UC) are at high risk for developing colorectal cancer (2); both extent and duration of intestinal inflammation further increase risk (3, 4). These associations suggest that chronic intestinal inflammation is a causative factor in carcinogenesis in patients with UC, and that there is a causal link between chronic inflammation and increased risk of cancer. These observations raise the question of the signaling pathways by which long-standing inflammation might underlie the development of cancer.Substance P (SP) is a proinflammatory neuropeptide described by von Euler and Gaddum (5) and later isolated and characterized by Chang and Leeman (6). SP is synthesized by a variety of cells, most notably neurons and inflammatory cells such as macrophages (7). SP's primary receptor, the neurokinin-1 receptor (NK-1R), can mediate a variety of physiologic and pathophysiologic responses, including cell proliferation, migration, and inflammation (8). The NK-1R has been identified in epithelial cells in rodent models of colonic inflammation (9, 10) and in patients with UC as well as Crohn disease (11)(12)(13)(14). However, not all of these studies are in agreement regarding epithelial NK-1R e...

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 97%

Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer

Gillespie¹,

Leeman²,

Watts³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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“…The European and US guidelines recommended that regular surveillance endoscopy should be initiated from six to eight years after the first manifestation of the disease [47,48].…”

Section: Ulcerative Colitismentioning

confidence: 99%

The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

Moriichi

Fujiya

Okumura

2016

Clin J Gastroenterol

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Image-enhanced endoscopy (IEE) has been developed and is applied in the clinical setting throughout the world. Most reports regarding IEE have evaluated the efficacy of narrow-band imaging (NBI) in the diagnosis of gastrointestinal disorders. Although autofluorescence imaging (AFI) is a form of IEE, its usefulness remains unclear. The present review focused on the efficacy of AFI in the diagnosis of colorectal disease, particularly neoplasia and ulcerative colitis (UC). AFI-based diagnoses are made via the subjective judgment of the color on the monitor. The efficacy of AFI in detection and differentiation in patients with colorectal neoplastic lesions remains controversial, which may be dependent on the study design and the diagnostic procedures. Although the number of the reports related to UC is very small, most suggest that AFI is effective in UC patients. AFI is distinct from other modalities in that it can quantitatively assess the lesion based on the fluorescence intensity without any morphological assessments. AFI could be useful for patients with colorectal disease.Keywords Autofluorescence imaging (AFI) Á Colorectal neoplasia Á Ulcerative colitis (UC) Á Colitis-associated cancer Á Narrow-band imaging (NBI) Á Image-enhanced endoscopy (IEE) Á White light endoscopy (WLE)

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“…However, if risk factors such as PSC, family history of sporadic CRC, longer disease duration, more extensive disease, multiple inflammatory pseudopolyps or colonic strictures are present, more frequent surveillance is advised and may also stress the patient to consider colectomy. Multiple four-quadrant biopsies of 10 cm each is the recommendation [33], but it is not frequently practiced. In the study by Eaden et al, approximately 300 British gastroenterologists were polled, but only 2% routinely performed more than 20 random biopsies [34].…”

Section: Surveillance Guidelinesmentioning

confidence: 99%

The surgical treatment of inflammatory bowel disease-associated dysplasia

Connelly

Koltun²

2013

Expert Review of Gastroenterology & Hepatology

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AGA Medical Position Statement on the Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease

Cited by 445 publications

References 1 publication

Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer

Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer

The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases

The surgical treatment of inflammatory bowel disease-associated dysplasia

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