Ag – ZnO Nanocomposites Cause Cytotoxicity and Induce Cell Cycle Arrest in Human Gastric and Melanoma Cancer Cells

Comparative study of antidiabetic, bactericidal, and antitumor activities of MEL@AgNPs, MEL@ZnONPs, and Ag–ZnO/MEL/GA nanocomposites prepared by using MEL and gum arabic

“…In contrast, previous studies indicated that Ag-ZnO nanocomposites' cytotoxicity is lower than a MEL@ZnONPs in the same dose range. 86 Arooj et al 87 conrmed that the antitumor efficiency of Ag-ZnO NCs (with 10-30% Ag amount) were more than ZnONPs to malignant melanoma HT144 cells under daylight exposure. In our study, we did not determine the Ag content as well as did not use a light source to improve the cytotoxicity of Ag-ZnO NCs.…”

Pristine Cu-MOF Induces Mitotic Catastrophe and Alterations of Gene Expression and Cytoskeleton in Ovarian Cancer Cells

“…20,52−55 For instance, Se and Ag nanoparticles blocked the cell cycle at S and G0/G1 phases, respectively, and inhibited tumor growth, 52,53 ZnO, TiO 2 , and Ag-ZnO nanoparticles caused G2/M arrest. 54,55 Previously reported Fe-MIL-101 inhibited SKOV3 growth mainly through causing G0/G1 cell cycle arrest. 20 To determine whether the Cu-MOF has an effect on the cell cycle, SKOV3 cells were detected using flow cytometry after treated with Cu-MOF for 48 h. The percent of cells in the G2/M phase increased from 15.4 to 50.1% (Table 3).…”

“…Among them, the G2/M phase plays a crucial role in mitosis processes in which a checkpoint will prevent the cell with damaged DNA from entering mitotic . Nanomaterials have been reported to inhibit tumor cell growth through the cell cycle arrest at different stages. ,− For instance, Se and Ag nanoparticles blocked the cell cycle at S and G0/G1 phases, respectively, and inhibited tumor growth, , ZnO, TiO 2 , and Ag-ZnO nanoparticles caused G2/M arrest. , Previously reported Fe-MIL-101 inhibited SKOV3 growth mainly through causing G0/G1 cell cycle arrest . To determine whether the Cu-MOF has an effect on the cell cycle, SKOV3 cells were detected using flow cytometry after treated with Cu-MOF for 48 h. The percent of cells in the G2/M phase increased from 15.4 to 50.1% (Table ).…”

Plant-Based Bimetallic Silver-Zinc Oxide Nanoparticles: A Comprehensive Perspective of Synthesis, Biomedical Applications, and Future Trends

“…The obtained results showed that concentrations of up to 0.1 mg/mL of biocapped Ag/ZnONCs induced no significant harmful to the cells [ 59 ]. Rad et al demonstrated that low concentrations of Ag/ZnO NPs possess cytotoxicity and induce dose-dependent cell death [ 102 ].…”