Ag<sub>2</sub>S-Glutathione quantum dots for NIR image guided photothermal therapy

Hashemkhani, Mahshid; Bilici, Kübra; Muti, Abdullah; Sennaroğlu, Alphan; Acar, Havva Yağcı

doi:10.1039/c9nj04608a

Cited by 24 publications

(32 citation statements)

References 38 publications

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“…It is well established that thermal ablation triggers necrosis ( Jaque et al, 2014 ). Although some organic molecules can be used as a PS for PTT ( Lv et al, 2020 ), recently metal nanoparticles ( Ke et al, 2011 ; He et al, 2014 ), metal oxide nanoparticles ( Chu et al, 2013 ; Bilici et al, 2018 ), and quantum dots ( Liang et al, 2018 ; Hashemkhani et al, 2020 ), especially with significant absorbance at near-infrared (NIR) for both better tissue penetration and safety due to its nonionizing nature ( Jaque et al, 2014 ), are preferred. Light-to-heat conversion efficiency, dark toxicity, selective tumor accumulation, photostability, and effective heating of the whole tumor are factors to consider for PTT.…”

Section: Photodynamic and Photothermal Therapymentioning

confidence: 99%

Recent Advances in Cyanine-Based Phototherapy Agents

et al. 2021

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Phototherapies, in the form of photodynamic therapy (PDT) and photothermal therapy (PTT), are very promising treatment modalities for cancer since they provide locality and turn-on mechanism for toxicity, both of which are critical in reducing off-site toxicity. Irradiation of photosensitive agents demonstrated successful therapeutic outcomes; however, each approach has its limitations and needs to be improved for clinical success. The combination of PTT and PDT may work in a synergistic way to overcome the limitations of each method and indeed improve the treatment efficacy. The development of single photosensitive agents capable of inducing both PDT and PTT is, therefore, extremely advantageous and highly desired. Cyanine dyes are shown to have such potential, hence have been very popular in the recent years. Luminescence of cyanine dyes renders them as phototheranostic molecules, reporting the localization of the photosensitive agent prior to irradiation to induce phototoxicity, hence allowing image-guided phototherapy. In this review, we mainly focus on the cyanine dye–based phototherapy of different cancer cells, concentrating on the advancements achieved in the last ten years.

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Section: Photodynamic and Photothermal Therapymentioning

confidence: 99%

Recent Advances in Cyanine-Based Phototherapy Agents

et al. 2021

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“…Semiconductor quantum dots (QDs) have attracted great interest as a novel class of promising optical probes in the past two decades. 1 , 2 Compared to bulk materials, they exhibit many advantages, such as size-dependent photoluminescence (PL), high PL quantum yields (QY), sharp and symmetrical fluorescence peaks, broad excitation spectra, large Stokes shifts, and long-lasting luminesce, which is valuable for medical imaging. 3 , 4 Recently, heavy metal-free ternary I–III–VI 2 QDs such as CuInS 2 , 5 CuInSe 2 , 6 and AgInS 2 7 , 8 have been intensively investigated.…”

Section: Introductionmentioning

confidence: 99%

One-Step Aqueous Synthesis of Anionic and Cationic AgInS₂ Quantum Dots and Their Utility in Improving the Efficacy of ALA-Based Photodynamic Therapy

et al. 2022

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Silver–indium–sulfide quantum dots (AIS QDs) have potential applications in many areas, including biomedicine. Their lack of regulated heavy metals, unlike many commercialized QDs, stands out as an advantage, but the necessity for alloyed or core–shell structures and related costly and sophisticated processes for the production of stable and high quantum yield aqueous AIS QDs are the current challenges. The present study demonstrates the one-step aqueous synthesis of simple AgInS 2 QD compositions utilizing for the first time either a polyethyleneimine/2-mercaptopropionic acid (AIS-PEI/2MPA) mixture or only 2-mercaptopropionic acid (AIS-2MPA) as the stabilizing molecules, providing a AgInS 2 portfolio consisting of cationic and anionic AIS QDs, respectively, and tuneable emission. Small AIS QDs with long-term stability and high quantum yields (19–23%) were achieved at a molar ratio of Ag/In/S 1/10/10 in water without any dopant or a semiconductor shell. The theranostic potential of these cationic and anionic AIS QDs was also evaluated in vitro. Non-toxic doses were determined, and fluorescence imaging potential was demonstrated. More importantly, these QDs were electrostatically loaded with zwitterionic 5-aminolevulinic acid (ALA) as a prodrug to enhance the tumor availability of ALA and to improve ALA-induced porphyrin photodynamic therapy (PDT). This is the first study investigating the influence of nanoparticle charge on ALA binding, release, and therapeutic efficacy. Surface charge was found to be more critical in cellular internalization and dark toxicity rather than drug loading and release. Both QDs provided enhanced ALA release at acidic pH but protected the prodrug at physiological pH, which is critical for tumor delivery of ALA, which suffers from low bioavailability. The PDT efficacy of the ALA-loaded AIS QDs was tested in 2D monolayers and 3D constructs of HT29 and SW480 human colon adenocarcinoma cancer cell lines. The incorporation of ALA delivery by the AIS QDs, which on their own do not cause phototoxicity, elicited significant cell death due to enhanced light-induced ROS generation and apoptotic/necrotic cell death, reducing the IC50 for ALA dramatically to about 0.1 and 0.01 mM in anionic and cationic AIS QDs, respectively. Combined with simple synthetic methods, the strong intracellular photoluminescence of AIS QDs, good biocompatibility of especially the anionic AIS QDs, and the ability to act as drug carriers for effective PDT signify that the AIS QDs, in particular AIS-2MPA, are highly promising theranostic QDs.

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“…Coupled with PTT and optical signal, these harmless Ag 2 S‐GSH QDs have great potential for theranostic applications. [ 89 ] Yong et al. reported a kind of WS 2 QDs via ultrasonication and physical grinding in a small size (3 nm).…”

Section: Multifunctional Inorganic Npsmentioning

confidence: 99%

All‐in‐One Nanomedicine: Multifunctional Single‐Component Nanoparticles for Cancer Theranostics

Cai

Chen

et al. 2021

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The development of cancer diagnostic imaging and treatment is a major concern worldwide. By integrating imaging and therapy into one theranostic nanoplatform for simultaneously detecting tumors, evaluating the targeting ability and timely monitoring therapeutic responses provide more opportunities for precision medicine. Among various theranostic nanosystems, a series of single‐component nanoparticles (NPs) have been developed for “all‐in‐one” theranostics, which presents the unique properties of facile preparation, simple composition, defined structure, high reproducibility, and excellent biocompatibility. Specifically, utilizing single‐component NPs for both diagnostics and therapeutics can reduce the possible numerous untoward side effects and risks to the living body. In this review, the recent progress of multifunctional single‐component NPs in the applications of cancer theranostics is systematically summarized. Notably, the structure design, categories of NPs, targeted strategies, biomedical applications, potential barriers, challenges, and prospects for the future clinical practice of this rapidly growing field are discussed.

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Ag₂S-Glutathione quantum dots for NIR image guided photothermal therapy

Abstract: Synthesis of ultrasmall, colloidally stable, biocompatible Ag2S-gluthatione quantum dots for NIR image guided-long wavelength photothermal therapy agents.

Cited by 24 publications

References 38 publications

Recent Advances in Cyanine-Based Phototherapy Agents

Recent Advances in Cyanine-Based Phototherapy Agents

One-Step Aqueous Synthesis of Anionic and Cationic AgInS₂ Quantum Dots and Their Utility in Improving the Efficacy of ALA-Based Photodynamic Therapy

All‐in‐One Nanomedicine: Multifunctional Single‐Component Nanoparticles for Cancer Theranostics

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Ag2S-Glutathione quantum dots for NIR image guided photothermal therapy

Abstract: Synthesis of ultrasmall, colloidally stable, biocompatible Ag2S-gluthatione quantum dots for NIR image guided-long wavelength photothermal therapy agents.

Cited by 24 publications

References 38 publications

Recent Advances in Cyanine-Based Phototherapy Agents

Recent Advances in Cyanine-Based Phototherapy Agents

One-Step Aqueous Synthesis of Anionic and Cationic AgInS2 Quantum Dots and Their Utility in Improving the Efficacy of ALA-Based Photodynamic Therapy

All‐in‐One Nanomedicine: Multifunctional Single‐Component Nanoparticles for Cancer Theranostics

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Ag₂S-Glutathione quantum dots for NIR image guided photothermal therapy

One-Step Aqueous Synthesis of Anionic and Cationic AgInS₂ Quantum Dots and Their Utility in Improving the Efficacy of ALA-Based Photodynamic Therapy