Ag Nanoparticles Cluster with pH‐Triggered Reassembly in Targeting Antimicrobial Applications

Xie, Xianli; Sun, Tian-Ci; Xue, Jingzhe; Miao, Zhaohua; Xu, Yan; Fang, Wei; Li, Qing; Tang, Rupei; Lü, Yang; Tang, Longxiang; Zha, Zhengbao; He, Tao

doi:10.1002/adfm.202000511

Cited by 114 publications

(98 citation statements)

References 56 publications

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“…On the 9th day, immunofluorescence technology was introduced to illustrate the expression of vascular endothelial growth factor (VEGF) and cluster of differentiation 45 (CD45) to evaluate angiogenesis and inflammation of the wound. [ 41 ] As shown in Figure 4G, much lower expression of CD45 observes in the groups of Fe‐iCOF‐Gel and Glucose + GFeF‐Gel, indicating less inflammation. Meanwhile, the immunofluorescence intensity of VEGF is almost the same due to blood vessel formation.…”

Section: Resultsmentioning

confidence: 97%

Ionic Covalent‐Organic Framework Nanozyme as Effective Cascade Catalyst against Bacterial Wound Infection

Wang

Líu

et al. 2021

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The increasing resistance risks of conventional antibiotic abuse and the formed biofilm on the surface of wounds have been demonstrated to be the main problems for bacteria‐caused infections and unsuccessful wound healing. Treatment by reactive oxygen species, such as the commercial H2O2, is a feasible way to solve those problems, but limits in its lower efficiency. Herein, an ionic covalent‐organic framework‐based nanozyme (GFeF) with self‐promoting antibacterial effect and good biocompatibility has been developed as glucose‐triggered cascade catalyst against bacterial wound infection. Besides the efficient conversion of glucose to hydrogen peroxide, the produced gluconic acid by loading glucose oxidase can supply a compatible catalytic environment to substantially improve the peroxidase activity for generating more toxic hydroxyl radicals. Meanwhile, the adhesion between the positively charged GFeF and the bacterial membrane can greatly enhance the healing effects. This glucose‐triggered cascade strategy can reduce the harmful side effects by indirectly producing H2O2, potentially used in the wound healing of diabetic patients.

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Section: Resultsmentioning

confidence: 97%

Ionic Covalent‐Organic Framework Nanozyme as Effective Cascade Catalyst against Bacterial Wound Infection

Wang

Líu

et al. 2021

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“…Experiments for in vivo wound healing demonstrated that pH-responsive silver nanoparticle clusters formed from the ortho ester inner layer and PEG corona (AgNCs) are effective for the healing of methicillin-resistant Staphylococcus aureus infections [77]. Transistors are usually utilized as electronic switches since they react pointedly with an amplified current output to an applied voltage threshold.…”

Section: Chemical-responsive Nanomaterialsmentioning

confidence: 99%

Smart Nanomaterials for Biomedical Applications—A Review

Aflori¹

2021

Nanomaterials

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Recent advances in nanotechnology have forced the obtaining of new materials with multiple functionalities. Due to their reduced dimensions, nanomaterials exhibit outstanding physio-chemical functionalities: increased absorption and reactivity, higher surface area, molar extinction coefficients, tunable plasmonic properties, quantum effects, and magnetic and photo properties. However, in the biomedical field, it is still difficult to use tools made of nanomaterials for better therapeutics due to their limitations (including non-biocompatible, poor photostabilities, low targeting capacity, rapid renal clearance, side effects on other organs, insufficient cellular uptake, and small blood retention), so other types with controlled abilities must be developed, called “smart” nanomaterials. In this context, the modern scientific community developed a kind of nanomaterial which undergoes large reversible changes in its physical, chemical, or biological properties as a consequence of small environmental variations. This systematic mini-review is intended to provide an overview of the newest research on nanosized materials responding to various stimuli, including their up-to-date application in the biomedical field.

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“…[124] Although SA-based hydrogel loaded with Ag NPs has good antibacterial ability, the loaded Ag NPs are unstable and released Ag ions exhibited obvious toxicity to normal cells and tissues. [125] Shin et al utilized formaldehyde as a reducing agent to prepare Ag NPs through the reduction reaction of Ag + that were electrostatically adsorbed onto the surface of TEMPO-oxidized cellulose nanofibers. [126] The immobilized Ag NPs were subsequently embedded in SA hydrogels.…”

Section: Natural Polymeric Matrixmentioning

confidence: 99%

Antibacterial Hybrid Hydrogels

Cao

Luo

et al. 2020

Macromolecular Bioscience

124

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Bacterial infectious diseases and bacterial‐infected environments have been threatening the health of human beings all over the world. In view of the increased bacteria resistance caused by overuse or improper use of antibiotics, antibacterial biomaterials are developed as the substitutes for antibiotics in some cases. Among them, antibacterial hydrogels are attracting more and more attention due to easy preparation process and diversity of structures by changing their chemical cross‐linkers via covalent bonds or noncovalent physical interactions, which can endow them with various specific functions such as high toughness and stretchability, injectability, self‐healing, tissue adhesiveness and rapid hemostasis, easy loading and controlled drug release, superior biocompatibility and antioxidation as well as good conductivity. In this review, the recent progress of antibacterial hydrogel including the fabrication methodologies, interior structures, performances, antibacterial mechanisms, and applications of various antibacterial hydrogels is summarized. According to the bacteria‐killing modes of hydrogels, several representative hydrogels such as silver nanoparticles‐based hydrogel, photoresponsive hydrogel including photothermal and photocatalytic, self‐bacteria‐killing hydrogel such as inherent antibacterial peptides and cationic polymers, and antibiotics‐loading hydrogel are focused on. Furthermore, current challenges of antibacterial hydrogels are discussed and future perspectives in this field are also proposed.

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Ag Nanoparticles Cluster with pH‐Triggered Reassembly in Targeting Antimicrobial Applications

Cited by 114 publications

References 56 publications

Ionic Covalent‐Organic Framework Nanozyme as Effective Cascade Catalyst against Bacterial Wound Infection

Ionic Covalent‐Organic Framework Nanozyme as Effective Cascade Catalyst against Bacterial Wound Infection

Smart Nanomaterials for Biomedical Applications—A Review

Antibacterial Hybrid Hydrogels

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