Ag+ Complexes as Potential Therapeutic Agents in Medicine and Pharmacy

Hecel, Aleksandra; Kołkowska, Paulina; Krzywoszyńska, Karolina; Szebesczyk, Agnieszka; Rowińska‐Żyrek, Magdalena; Kozłowski, Henryk

doi:10.2174/0929867324666170920125943

Cited by 26 publications

(16 citation statements)

References 208 publications

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“…Recently, a review by Hecel focused on antimicrobial and anticancer applications of silver and silver complexes. The review also summarized the pharmacological applications of silver nanoparticles [110] …”

Section: Medicinal Applicationsmentioning

confidence: 99%

Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications

Nayak

Gaonkar

2021

ChemMedChem

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New weapons are constantly needed in the fight against cancer. The discovery of cisplatin as an anticancer drug prompted the search for new metal complexes. The successful history of cisplatin motivated chemists to develop a plethora of metal‐based molecules. Among them, metal‐N‐heterocyclic carbene (NHC) complexes have gained significant attention because of their suitable qualities for efficient drug design. The enhanced applications of coinage metal‐NHC complexes have encouraged a gradually increasing number of studies in the fields of medicinal chemistry that benefit from the fascinating chemical properties of these complexes. This review aims to present recent developments in synthetic strategies and medicinal applications of copper, silver and gold complexes supported by NHC ligands.

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Section: Medicinal Applicationsmentioning

confidence: 99%

Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications

Nayak

Gaonkar

2021

ChemMedChem

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“…Многие авторы на основе наблюдений и исследований сообщают в числе различных свойств протеината серебра о его выраженном антисептическом действии [17][18][19][20][21]. Важно отметить, что препарат активен в отношении пато-генных микроорганизмов, которые чаще других вызывают развитие риносинусита: Str.…”

Section: оториноларингология/Otorhinolaryngologyunclassified

Effective and safe treatment for the inflammatory diseases of the nose and nasopharynx

Овчинников¹,

Мирошниченко²,

Nikolaeva³

2020

Russian Medical Inquiry

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Inflammatory diseases of the nasal cavity and paranasal sinuses are identified as the leading cause of upper respiratory disorders. Nose breathing is of crucial importance to provide the entry for air to get into the respiratory system. In addition to oxygen saturation, nose breathing provides the exchange of air in the paranasal sinuses. This process is required to maintain normal microflora of the nasal cavity. In contrast, mouth breathing occurring during the inflammatory diseases of the nasal cavity is associated with discomfort and poor health-related quality of life and results in inflammation. Viral inflammatory disorders often exacerbate a patient’s condition and provoke bacterial inflammation. Recent widespread occurrence of antimicrobial resistance forced to change the paradigm in the treatment of inflammatory disorders and to refocus on time-proved topical therapies. Systemic antibiotics are now used only for strict indications. Other treatment options are widely applied. Thus, silver preparations characterized by antiseptic and bactericidal properties allow to avoid complications and to aid the recovery. They are the best choice of topical agents for treating acute rhinosinusitis. KEYWORDS: acute rhinitis, acute rhinosinusitis, acute respiratory viral infections, antibacterial drugs, topical treatment, argentum proteinate. FOR CITATION: Ovchinnikov A.Yu., Miroshnichenko N.A., Nikolaeva Yu.O. Effective and safe treatment for the inflammatory diseases of the nose and nasopharynx. Russian Medical Inquiry. 2020;4(4):238–242. DOI: 10.32364/2587-6821-2020-4-4-238-242.

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“…Metal complexes with unique characteristics, including reactivity, different coordination routes and redox ability, showed tremendous potential in cancer therapy. These complexes showed a better cytotoxic action than the ligands through reactive oxygen species (ROS) production, cell membrane alteration, inhibiting DNA replication, affecting electron transport and perturbation of enzyme action and altering redox potential of the cell [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%