Ag and Ag/N2 plasma modification of polyethylene for the enhancement of antibacterial properties and cell growth/proliferation

Zhang, Wei; Luo, Yunjun; Wang, Huaiyu; Jiang, Jiang; Pu, Shihao; Chu, Paul K.

doi:10.1016/j.actbio.2008.05.012

Cited by 80 publications

(74 citation statements)

References 28 publications

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“…Further studies found that various gases, including NH 3 , O 2 and N 2 , co-implanted with Cu into PE surfaces induced slower release of Cu ions and higher antibacterial activity compared to Cu-PIII-PE, indicating enhancement in long-term antibacterial performance [87]. Similar observation was also found for Ag/N 2 co-implanted sample [88]. Chemical state analyses showed that the gas plasma implantation led to dehydrogenation and produced unsaturated C¼O, C¼C2, 2C;N and 2C¼N bonds, which are believed to be capable of adjusting the release rate of Cu or Ag and have an appreciable effect on bacteria killing.…”

Section: Antibacterial Activity Of Plasma Immersion Ion Implantation supporting

confidence: 71%

Surface modification of biomaterials using plasma immersion ion implantation and deposition

2012

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Although remarkable progress has been made on biomaterial research, the ideal biomaterial that satisfies all the technical requirements and biological functions is not available up to now. Surface modification seems to be a more economic and efficient way to adjust existing conventional biomaterials to meet the current and ever-evolving clinical needs. From an industrial perspective, plasma immersion ion implantation and deposition (PIII&D) is an attractive method for biomaterials owing to its capability of treating objects with irregular shapes, as well as the control of coating composition. It is well acknowledged that the physico-chemical characteristics of biomaterials are the decisive factors greatly affecting the biological responses of biomaterials including bioactivity, haemocompatibility and antibacterial activity. Here, we mainly review the recent advances in surface modification of biomaterials via PIII&D technology, especially titanium alloys and polymers used for orthopaedic, dental and cardiovascular implants. Moreover, the variations of biological performances depending on the physico-chemical properties of modified biomaterials will be discussed.

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Section: Antibacterial Activity Of Plasma Immersion Ion Implantation supporting

confidence: 71%

Surface modification of biomaterials using plasma immersion ion implantation and deposition

2012

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“…Based on cell assays, the Ag PIII polyethylene samples exhibited excellent biocompatibility for cells, demonstrating that Ag PIII not only enhances antibacterial properties but also improves the cell biocompatibility of polyethylene. 23 Hemostatic performance of n-BGs Figure 8 shows the clotting time of n-BGS and BGS, measured using the PT and APTT assays. The results display the effects of a nanoporous structure on the hemostatic activity of n-BGS.…”

Section: Cytotoxicity Of N-bgsmentioning

confidence: 99%

Antibacterial hemostatic dressings with nanoporous bioglass containing silver

Liang²,

Tong³

et al. 2012

IJN

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Nanoporous bioglass containing silver (n-BGS) was fabricated using the sol-gel method, with cetyltrimethyl ammonium bromide as template. The results showed that n-BGS with nanoporous structure had a surface area of 467 m 2 /g and a pore size of around 6 nm, and exhibited a significantly higher water absorption rate compared with BGS without nanopores. The n-BGS containing small amounts of silver (Ag) had a slight effect on its surface area. The n-BGS containing 0.02 wt% Ag, without cytotoxicity, had a good antibacterial effect on Escherichia coli, and its antibacterial rate reached 99% in 12 hours. The n-BGS's clotting ability significantly decreased prothrombin time (PT) and activated partial thromboplastin time (APTT), indicating n-BGS with a higher surface area could significantly promote blood clotting (by decreasing clotting time) compared with BGS without nanopores. Effective hemostasis was achieved in skin injury models, and bleeding time was reduced. It is suggested that n-BGS could be a good dressing, with antibacterial and hemostatic properties, which might shorten wound bleeding time and control hemorrhage.

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“…In comparison to a coating without silver, tests with Escherichia coli confirmed the antibacterial activity of the silver while an examination of osteoblast morphology revealed no obvious difference between both coatings. Furthermore, the release of silver was also examined for amino-hydrocarbon plasma polymer coatings (Lischer et al, 2011), after plasma immersion ion implantation into polyethylene (Zhang et al, 2008) and for silver nanoparticles bound to an allylamine plasma polymer thin film (Vasilev et al, 2010b). Similarly, the use of copper for antibacterial implant coatings has also been studied by plasma implantation into polyethylene (Zhang et al, 2007).…”

Section: Implant Surfaces With Antibacterial Propertiesmentioning

confidence: 99%