Antibacterial hemostatic dressings with nanoporous bioglass containing silver

Abstract

Nanoporous bioglass containing silver (n-BGS) was fabricated using the sol-gel method, with cetyltrimethyl ammonium bromide as template. The results showed that n-BGS with nanoporous structure had a surface area of 467 m 2 /g and a pore size of around 6 nm, and exhibited a significantly higher water absorption rate compared with BGS without nanopores. The n-BGS containing small amounts of silver (Ag) had a slight effect on its surface area. The n-BGS containing 0.02 wt% Ag, without cytotoxicity, had a good antibacterial effect on Escherichia coli, and its antibacterial rate reached 99% in 12 hours. The n-BGS's clotting ability significantly decreased prothrombin time (PT) and activated partial thromboplastin time (APTT), indicating n-BGS with a higher surface area could significantly promote blood clotting (by decreasing clotting time) compared with BGS without nanopores. Effective hemostasis was achieved in skin injury models, and bleeding time was reduced. It is suggested that n-BGS could be a good dressing, with antibacterial and hemostatic properties, which might shorten wound bleeding time and control hemorrhage.

Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process

“…[30][31][32][33][34][35][36][37][38][39][40][41][42] Electrospun Agcontaining polymer nanofiber mats have been intensively investigated for potential biomedical applications, such as wound-dressing materials, body wall repairs, augmentation devices, tissue scaffolds, and antimicrobial filters. [43][44][45][46][47] However, all the nanofibers were prepared using a single fluid electrospinning approach involving codissolving solutions of polymer and silver nitrate (AgNO 3 ).…”

Photodynamic antimicrobial chemotherapy for <em>Staphylococcus aureus</em> and multidrug-resistant bacterial burn infection in vitro and in vivo

“…These materials have good antibacterial efficiency. [21][22][23][24] Photodynamic antimicrobial chemotherapy (PACT) is a promising method to eradicate pathogenic bacteria, because it kills these via cytotoxic reactive oxygen species (ROS). ROS are produced by the photosensitive drug after light irradiation, and inflict aspecific damage to bacteria.…”

Mechanical characteristic and biological behaviour of implanted and restorative bioglasses used in medicine and dentistry: A systematic review

“…-Ag and Sr substituted bioactive glass for the investigation of antibacterial effects [19,20]; -Focused on cells growth, proliferation and protein interactions [21][22][23][24][25][26][27]; -Studies evaluating only the bioactivity and hydroxyl apatite (HA) formation [28][29][30][31][32][33][34]; -General characterization and synthesis of bioglass powders [35,36]; -Mechanical properties of a bioactive ceramic ␤-TCP [37].…”