African Swine Fever Virus Infection of Porcine Aortic Endothelial Cells Leads to Inhibition of Inflammatory Responses, Activation of the Thrombotic State, and Apoptosis

Vallée, Isabelle; Tait, Stephen W.G.; Powell, Penny P.

doi:10.1128/jvi.75.21.10372-10382.2001

Cited by 51 publications

(40 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The virus can infect dendritic cells as well as endothelial cells, however, the main target cells for the virus replication in vitro and in vivo remains the macrophages (Rodriguez et al, 1996a, Vallee et al, 2001. At late stages of the infection, the virus can infect other types of cells like megakaryocytes, platelets, neutrophils or hepatocytes (Carrasco et al, 1992, Fernandez et al, 1992a, Fernandez et al, 1992b.…”

Section: Page 16mentioning

confidence: 99%

Scientific review on African Swine Fever

Sánchez‐Vizcaíno

Martínez‐López

Martínez‐Avilés

et al. 2009

EFSA Supporting Publications

View full text Add to dashboard Cite

The present document has been produced and adopted by the bodies identified above as authors. In accordance with Article 36 of Regulation (EC) No 178/2002, this task has been carried out exclusively by the authors in the context of a grant agreement between the European Food Safety Authority and the authors. The present document is published complying with the transparency principle to which the European Food Safety Authority is subject. It may not be considered as an output adopted by EFSA. EFSA reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. The present document has been produced and adopted by the bodies identified above as authors. In accordance with Article 36 of Regulation (EC) No 178/2002, this task has been carried out exclusively by the authors in the context of a grant agreement between the European Food Safety Authority and the authors. The present document is published complying with the transparency principle to which the European Food Safety Authority is subject. It may not be considered as an output adopted by EFSA. EFSA reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors.Page 3 DEFINITION and DISTRIBUTIONAfrican Swine Fever (ASF) is caused by a complex DNA virus classified in the Asfarviridae family, genus Asfivirus, which infects different species of soft ticks and wild and domestic pigs. In the vertebrate hosts, the aetiological agent replicates preferentially in monocyte and macrophage cells and causes a range of symdromes and lesions from peracute to chronic and unapparent forms of disease.Actually, it is one of the most important diseases of domestic pigs, being of an exceptional seriousness, which can easily spread abroad and for which sanitary and socio-economical consequences have a significant impact on the national and international trade of animals and animal products. For this reason, it is listed as a Notifiable disease to the World Animal HealthOrganisation (OIE). At present there is no treatment or vaccine available, and control is based on rapid laboratory diagnosis and the enforcement of strict sanitary measures (Sanchez-Vizcaino, 2006). The virus has been maintained in African wild swine for a very long time: in eastern and southern Africa it is found in warthogs (Phacochoerus aethiopicus) and bushpigs (Potamochoerus porcus) also it is found in soft ticks of Ornithodoros genus. The wild swine in Africa can stay infected over a long period without showing any symptom of the disease -and thus can be considered as natural reservoirs of the disease, in contrast to the European wild boar (Sus scrofa) which appear to be highly susceptible (McVicar et al., 1988). The virus can be transmitted between O. moubata ticks by trans-stadial transmission as well as by sexual and trans-ovarian pathway, in contrast to O. erraticus in Europe where only trans...

show abstract

Section: Page 16mentioning

confidence: 99%

Scientific review on African Swine Fever

Sánchez‐Vizcaíno

Martínez‐López

Martínez‐Avilés

et al. 2009

EFSA Supporting Publications

View full text Add to dashboard Cite

show abstract

“…Cytokines released by immune and inflammatory cells and by the endothelial cells can also activate the endothelium and take part in different mechanisms of pathogenesis. In other hemorrhagic infections, such as the African swine fever or Dengue, involvement of endothelial cells in pathogenesis has been demonstrated [14,23].…”

Section: E Campos Et Almentioning

confidence: 99%

In vitro effect of classical swine fever virus on a porcine aortic endothelial cell line

Campos¹,

Revilla²,

Chamorro³

et al. 2004

Vet. Res.

View full text Add to dashboard Cite

-The effect of classical swine fever (CSF) virus on some phenotypic and functional features of an established porcine aortic endothelial cell (AOC) line was investigated. AOC cells show most of the characteristics of primary endothelial cells, avoiding the alterations and senescence that these cells undergo after a few passages in culture. AOC cells were susceptible to CSF virus infection to a high degree, reaching 90% of CSF virus positive cells after 24 h of infection; however as with other porcine susceptible cells, no cytopathic effect could be observed. In these conditions none of the surface molecules studied, including SLA-II MHC antigens, adhesion or co-stimulatory molecules, were altered by virus infection after 24 or 48 h. Functionally CSF virus infection induced a decrease in the pro-coagulant activity of the AOC cells, determined by the increase in the clot formation time shown by the lysates of these cells. This contrasts with the increase observed in the expression of mRNA corresponding to IL-1α and IL-6, two proinflammatory and pro-coagulant cytokines, in CSF virus-infected AOC cells.classical swine fever / endothelial cells / cytokines / pro-coagulant activity

show abstract

“…However, recent studies using ASFV with deleted MGF360/530 showed the association of these multigenic families in the transcription inhibition of the interferon gene and in interferon activation pathways (2). Other studies involving infection with virulent ASFV without these multigenic families deleted also described an inhibition in the IFN transcripts in the porcine aortic endothelial cells culture (31). Genetic variation in ASFV strain might be an obvious explanation for pathogenicity of these two ASFV strains; NHV virus has a naturally occurring deletion in the MGF360/530 genes in contrast to the presence of those genes in the L60 strain.…”

mentioning

confidence: 99%

Transcriptional immunoresponse of tissue-specific macrophages in swine after infection with African swine fever virus

Kowalczyk

Kozak

Łyjak

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

View full text Add to dashboard Cite

Macrophages and cytokines are important in the control of inflammation and regulation of the immune response. However, they can also contribute to immunopathology in the host after viral infection and the regulatory network can be subverted by infectious agents, including viruses, some of which produce cytokine analogues or have mechanisms that inhibit cytokine function. African swine fever virus (ASFV) encodes a number of proteins which modulate cytokine and chemokine induction, host transcription factor activation, stress responses, and apoptosis. The aim of this review is to elucidate the mechanisms of immune responses to ASFV in different subpopulations of porcine macrophages. A transcriptional immune response in different resident tissue macrophages following ASFV infection was presented in many publications. ASFV-susceptible porcine macrophages can be of several origins, such as peripheral blood, lungs, bone marrow, etc. blood monocytes, blood macrophages, and lung macrophages have demonstrated a modulation of phenotype. Monocyte-derived macrophages could express surface markers not found on their monocyte precursors. Moreover, they can undergo further differentiation after infection and during inflammation. When viruses infect such cells, immunological activity can be seriously impaired or modified.

show abstract

African Swine Fever Virus Infection of Porcine Aortic Endothelial Cells Leads to Inhibition of Inflammatory Responses, Activation of the Thrombotic State, and Apoptosis

Abstract: African swine fever (ASF) is an asymptomatic infection of warthogs and bushpigs

Cited by 51 publications

References 48 publications

Scientific review on African Swine Fever

Scientific review on African Swine Fever

In vitro effect of classical swine fever virus on a porcine aortic endothelial cell line

Transcriptional immunoresponse of tissue-specific macrophages in swine after infection with African swine fever virus

Contact Info

Product

Resources

About