African Natural Products with Potential Anti-trypanosomal Properties: A Review

Bashir, L.U.; Shittu, Oluwatosin Kudrat; Sani, Sabitu; Busari, Musa Bola; Adeniyi, K.O.

doi:10.9734/ijbcrr/2015/16039

Cited by 43 publications

(41 citation statements)

References 33 publications

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“…To identify natural products from African flora and fauna with antioxidant and hepatoprotective potentials, a review was compiled based on scientific literature from various sources including; Google Scholar, Science Direct, PubMed, Medline, Science domain [19,22,26,27]. The keywords used for identification of relevant data included the following terms; antioxidant, radical scavenging activities, anti-aging principles, reactive oxygen species, free radicals, African medicinal plants, natural product, 2,2-Diphenyl-1-picrylhydrazyl radical scavenging assay (DPPH), reducing properties and lipid peroxidations.…”

Section: Methodology (Search Strategy)mentioning

confidence: 99%

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African natural products with potential antioxidants and hepatoprotectives properties: a review

et al. 2016

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Free radicals are highly reactive molecules generated during oxidation reactions which in turn initiate chain reactions resulting to cellular damage. There is substantial evidence implicating free radicals especially reactive oxygen species (ROS) in the etiology of more than one hundred degenerative disorders in humans including, arthritis, atherosclerosis, ischemia and reperfusion injury of many tissues, gastritis, diabetics, central nervous system injury, acquired immunodeficiency syndrome (AIDS) and cancer. Scientific evidence postulates that bioactive compounds especially from natural products are capable of providing protection against free radicals. Consequently, few decades have witnessed a surfeit of research geared towards validating the antioxidant and hepatoprotective potential of the natural products. In this review, African natural products whose antioxidants activities were scientifically validated either in their crude extracts and/or derived products have been discussed. A total 1076 plants species representing 287 family, 132 isolated compounds and 7 insect/mollusk secreation were found. The plant species from the following families; Fababceae, Asteraceae, Lamiaceae, Moraceae, Euphorbiaceae, Combretaceae and Malvaceae have received more scientific attention than others. Analysis of the reports revealed that Combretum apiculatum, Telfaria occidentalis, Acalypha racemosa, Garcinia lucida were the most active plant extracts from African flora. The most active ROS-detoxifying phytochemicals were moracin T, U, S and R (84-87), oleanolic acid (54), 5,7,4′-trihydroxy-3,8,3′,5′-tetramethoxyflavone (89), 5,7,3′-trihydroxy-3,8,4′,5′-trimethoxyflavone (88), luteolin (3′,4′,5,7-tetrahydroxy flavone) (117) and genistein (4′,5,7-trihydroxyisoflavone) (116). The significant antioxidant potential demonstrated by some crude extracts and their constituent compounds render them good candidates for the development of new drugs. Although, the study of the mechanisms of actions as well as clinical validation of some of these isolated compounds is lacking. It is hoped that pertinent scientist and stakeholders will look further into some of these compounds for detailed authentification and subsequent commercialization.

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Section: Methodology (Search Strategy)mentioning

confidence: 99%

“…Africa is blessed with enormous biodiversity of natural product for healing practices [19]. From time immemorial Africa medicinal plants have been used by virtually all cultures to meet their health care needs.…”

Section: Introductionmentioning

confidence: 99%

African natural products with potential antioxidants and hepatoprotectives properties: a review

et al. 2016

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“…Different extracts from African medicinal plants have been tested to identify the source of the therapeutic effects [5][6][7]. As a result some natural products have been approved as new antioxidants and antibacterial drugs, but there is still an urgent need to identify novel substances that are safe, inexpensive and active towards free radicals and pathogens with high resistance [8].…”

Section: Introductionmentioning

confidence: 99%

In-vitro antioxidants, antimicrobial and toxicological evaluation of Nigerian Zingiber officinale

et al. 2018

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Background: Zingiber officinale is a rhizome commonly consumed as a delicacy, medicine or spice. It is considered as a safe spice with several medicinal properties. The aim of this study was to evaluate in-vitro antioxidants, antimicrobial and safety of Nigerian Z. Officinale. Methods: Methanol extract of Nigerian Z. Officinale (MEZO) was evaluated for phytochemical composition, total flavonoids and phenol contents using standard procedures. Antibacterial study was carried out via the agar well diffusion method. Antioxidant activities were carried out using 2, 2′-diphenyl-1-picrylhydrazyl (DPPH), and ferric reducing antioxidant properties (FRAP) assay. Twenty five (25) wister rats were randomly grouped into five (A-E) of five animals each. Animals in Groups AD were orally administered 75,150, 300 and 600 mg/kg bwt of the extract on daily basis for 4 weeks while those in Group A (control) received distilled water. Results: Total phenolic and flavonoids contents of the extract were 15.24 ± 0.02 mg GAE/g and 19.84 ± 0. 32 mg/g CE respectively. The extract promoted an inhibition of free radicals with IC 50 values of 47.05 ± 2. 03 μg/mL and 89.15 ± 0.29 μg/mL in DPPH and FRAP assay. At extract concentration of 100 μg/mL, K. pneumoniae showed the highest susceptibility of 29.04 ± 0.35 mm, followed by P. aeuruginisa (26.03 ± 0.41 mm), while S. aureus (15.08 ± 0.20 mm) was least susceptible. The serum concentrations of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), sodium, albumin, total proteins and the computed organs/body weight ratios compared favorably (p > 0.05) with control at all extract doses tested. The bilirubin, urea and creatinine levels significantly (p < 0.05) increase while chloride decreases in rats dosed 600 mg/kg bwt. However, potassium level increases significantly (p < 0.05) in rats dose 300 mg/kg of the extract when compare with the control. Conclusion: This study revealed the strong antioxidant and antimicrobial potentials of methanol extract of Nigerian Zingiber officinale. It was also found to be relatively safe for consumption and thus could serve as a source of candidate for the development of new antioxidants and antimicrobial drugs.

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“…In developing countries of the world, most the people depend on herbal medical care. The popularity of traditional medicine is due to the belief that some diseases only respond to traditional treatment [5].…”

Section: Introductionmentioning

confidence: 99%

Haematopoetic effect of methanol extract of Nigerian honey bee (Apis mellifera) propolis in mice

Lawal¹,

Shittu²,

Abubakar³

et al. 2015

J Coast Life Med

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African Natural Products with Potential Anti-trypanosomal Properties: A Review

Cited by 43 publications

References 33 publications

African natural products with potential antioxidants and hepatoprotectives properties: a review

African natural products with potential antioxidants and hepatoprotectives properties: a review

In-vitro antioxidants, antimicrobial and toxicological evaluation of Nigerian Zingiber officinale

Haematopoetic effect of methanol extract of Nigerian honey bee (Apis mellifera) propolis in mice

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