Aflatoxin B1, zearalenone and deoxynivalenol in feed ingredients and complete feed from different Province in China

Wu, Li; Li, Jianjun; Li, Yunhu; Li, Tiejun; He, Q.; Tang, Yulong; Liu, Hongnan; Su, Yongteng; Yin, Yulong; Liao, Peng

doi:10.1186/s40104-016-0122-8

Cited by 59 publications

(57 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Deoxynivalenol (DON) is a trichothecene mycotoxin that is mainly produced by Fusarium graminearum and Fusarium culmorum and is named for its ability to cause nausea and vomiting in animals [1,2]. DON pollution is common worldwide, and DON has the highest detection rate and overstandard rate among all mycotoxins [3][4][5][6]. DON promotes oxidative stress, changes intestinal morphology, and affects nutrient absorption.…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of the Antioxidant and Intestinal Protective Effects of Baicalin-Copper in Deoxynivalenol-Challenged Piglets

Zha

Yuan

Cui

et al. 2020

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

The present study was performed to evaluate the antioxidant and intestinal protective effects of baicalin-copper on deoxynivalenol-challenged piglets. Forty weaned piglets were randomly divided into four groups and assigned to different diets: (1) basal diet (Con), (2) 4 mg/kg deoxynivalenol of basal diet (DON), (3) 5 g/kg baicalin-copper of basal diet (BCU); and (4) 4 mg/kg deoxynivalenol+5 g/kg baicalin‐copper of basal diet (DBCU). The results showed that the ADFI and ADG of piglets in the DON group were markedly lower than those in the Con group, but the ADFI and ADG of the DBCU group were not significantly different from those of the Con group. In piglets fed a DON-contaminated diet, dietary supplementation with BCU significantly decreased the mRNA levels of P70S6K, 4E-BP1, and HSP70 in the liver, the protein expression of HO-1 in the jejunum, and the expression of p-Nrf2 and p-NF-κB in the ileum but increased Mn-SOD activity in serum. Dietary supplementation with BCU increased jejunal maltase, ZIP4 and MT mRNA levels, and serum concentrations of Arg, Val, Ile, Leu, Lys, and Tyr in DON-contaminated piglets. In summary, BCU can alleviate the growth impairment induced by DON and enhance antioxidant capacity and nutrition absorption in piglets fed DON-contaminated diets.

show abstract

Section: Introductionmentioning

confidence: 99%

The Evaluation of the Antioxidant and Intestinal Protective Effects of Baicalin-Copper in Deoxynivalenol-Challenged Piglets

Zha

Yuan

Cui

et al. 2020

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, in southern Europe, although 43% of wheat tested contained aflatoxins, the maximum value was only 6 μg kg -1 (Guerre, 2016). Examination of AFB 1 in the period 2013-2015 in China showed the highest content of AFB 1 was in soybean, it was lower in corn and bran, and the lowest values were in wheat (Li et al, 2016). In the same research, in feed mixtures, the highest content of AFB 1 was in pig feed mixtures, while it was lower in feeding dough and in cattle feed mixtures.…”

Section: Feed As Source Of Aflatoxinsmentioning

confidence: 94%

Aflatoxins in feed

Jovanović¹,

Marković²,

Radulović³

et al. 2018

VET GLASNIK

View full text Add to dashboard Cite

Background. Mycotoxins are toxic secondary metabolites, which are synthesized from a large number of intermediates from the primary metabolism of saprophytic molds. Aflatoxins, due to their genotoxic and carcinogenic effects, are the most important group of mycotoxins from the aspect of their impact on human and animal health. Of all known aflatoxins, AFB1 is the most frequent, with the most harmful impact on human and animal health.Scope and Approach. Due to their prevalence and toxicity, monitoring the presence of aflatoxins in the food chain is required. The scope of this paper is to provide information on the presence of aflatoxins in animal feed and in milk. This paper describes temperature increases in Europe that are contributing to the increased presence of aflatoxins in food, as well as aflatoxin prevention and protection measures.Key Findings and Conclusions. During the last decade, serious contamination of corn with aflatoxins was recorded in southern Europe. In the summer of 2012, Serbia recorded high concentrations of aflatoxins in corn and milk. Based on climate change data, it is expected that aflatoxin contamination in corn will become more frequent.

show abstract

“…Mycotoxins are unavoidable in feed, and the health of humans and animals are seriously threatened by the contamination of mycotoxins [1,2]. A atoxins (AF) are derivatives of dihydrofuran coumarin, which are secondary metabolites of aspergillus fungi Aspergillus parasitic and Aspergillus avus.…”

Section: Introductionmentioning

confidence: 99%

Lycopene alleviates AFB1-induced liver damage possibly through inhibiting cytochrome 450 isozymes and improving Nrf2-miediated detoxification and antioxidant systems in broiler chickens

Wan

Yang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Dietary constituents in certain bioactive substances may alleviate the toxicity of aflatoxin B1 (AFB1). Lycopene is a natural bioactive substance with powerful antioxidant, this study investigated whether dietary lycopene supplementation could alleviate AFB1-induced liver damage through inhibiting cytochrome P450 (CYP450) isozymes and improving detoxification and antioxidation with nuclear factor erythroid 2-related factor 2 (Nrf2) activation in broiler chickens. 320 healthy one-day-old male broiler chickens were randomly allotted into five groups and fed basal diet (Control), basal diet with AFB1 and 0, 100, 200 or 400 mg/kg lycopene, respectively. At 42 days of age, 8 broiler chickens per group were sampled.Results Compared to the control group, AFB1-exposed birds had depressed growth performance, hepatotoxicity and oxidative damage. The various lycopene levels prevented AFB1-induced growth depression, decreased activities and mRNA expressions of hepatic CYP450 isozymes, reduced reactive oxygen species and oxidative damage products, improved reduced glutathione (GSH)-dependent detoxification system and antioxidant system. Moreover, lycopene elevated the mRNA expressions of Nrf2 and its target genes, containing glutathione-s-transferase isozymes, GSH synthesis-related enzymes and antioxidases in AFB1-exposed broiler chickens.Conclusions As an effective anti-stress and hepatoprotective antioxidant, lycopene alleviated AFB1-induced liver damage possibly through inhibiting CYP450 isozymes and improving Nrf2-mediated detoxification and antioxidant systems in broiler chickens. Therefore, Lycopene and lycopene-enriched materials could be taken into consideration as effective hepatoprotective and anti-stress additives in poultry, and benefit the resulting food safety.

show abstract

Aflatoxin B1, zearalenone and deoxynivalenol in feed ingredients and complete feed from different Province in China

Cited by 59 publications

References 29 publications

The Evaluation of the Antioxidant and Intestinal Protective Effects of Baicalin-Copper in Deoxynivalenol-Challenged Piglets

The Evaluation of the Antioxidant and Intestinal Protective Effects of Baicalin-Copper in Deoxynivalenol-Challenged Piglets

Aflatoxins in feed

Lycopene alleviates AFB1-induced liver damage possibly through inhibiting cytochrome 450 isozymes and improving Nrf2-miediated detoxification and antioxidant systems in broiler chickens

Contact Info

Product

Resources

About