Aflatoxin B1 Promotes Cell Growth and Invasion in Hepatocellular Carcinoma HepG2 Cells through H19 and E2F1

Lv, Jun; Yu, Yanmin; Li, Shu-Qun; Luo, Liang; Wang, Qian

doi:10.7314/apjcp.2014.15.6.2565

Cited by 52 publications

(36 citation statements)

References 27 publications

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“…Aflatoxin or dioxin (herbicide) agents (Villar et al, 2012;Jun et al, 2014), cryptogenic cirrhosis (Somboon et al, 2014) as well as liver fluke, Opisthorchis viverrini (Ngoan et al, 2001), were not recorded. Difference in ratio or proportion was examined by a Pearson chi-square test.…”

Section: Methodsmentioning

confidence: 99%

Characteristics of Liver Cancer at Khmer-Soviet Friendship Hospital in Phnom Penh, Cambodia

Narin

Hamajima²,

Kouy³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Methodsmentioning

confidence: 99%

Characteristics of Liver Cancer at Khmer-Soviet Friendship Hospital in Phnom Penh, Cambodia

Narin

Hamajima²,

Kouy³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…After exposure and activation of AFB1, up-regulation of H19 gene (an imprinted oncofetal gene) is produced in HCC HepG2 cells with concentrations of AFB1 of 5-20µg/mL and an expression level peak with concentration of 40µg/mL AFB1. This can allowed the over-expression of E2F1 protein promoting cell growth in HCC HepG2 cells and cellular invasion [14].…”

Section: Carcinogenic Effect Of Afb1mentioning

confidence: 99%

The Relationship of Aflatoxin B1 and Hepatocellular Carcinoma: A Mini Review

Valdes¹

2017

JLRDT

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Hepatocellular carcinoma is one of the most important liver disease, been the fifth most common cause of cancer, and the second most common cause of cancer-related death worldwide. The presence of aflatoxin B1has become an important factor in identifying the genesis of the HCC. Mutation of the p53 tumor suppressor gene, up-regulation of H19 gene and over-expression of E2F1 protein, have been address at the time to determine which factors are essential in hepatocarcinogenesis, and the synergistic relation with HBV favoring gene mutation.

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“…It is an imprinted oncofetal gene, located on chromosome 11p15.5 and lies within 200 kb downstream of the IGF-2 gene. The loss of imprinting at the H19 locus typically results in an overexpression of H19 in liver cancer [67,68] . IGF-2 and H19 alleles are selectively expressed as these two genes are imprinted in the opposite directions [67] .…”

Section: H19mentioning

confidence: 99%

“…These data suggest that AFB1 could regulate HepG2 cells' growth and invasion via association with E2F1 and H19. This is the first known study of the relationship among mRNA-like ncRNA, H19 and AFB1 [68] .…”

Section: H19mentioning

confidence: 99%

Non-coding RNAs: New therapeutic targets and opportunities for hepatocellular carcinoma

Ning

et al. 2016

Adv Mod Oncol Res

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Non-coding RNAs (ncRNA) are RNA molecules without protein coding functions owing to the lack of an open reading frame (ORF). Based on the length, ncRNAs can be divided into long and short ncRNAs; short ncRNAs include miRNAs and piRNAs. Hepatocellular carcinoma (HCC) is among the most frequent forms of cancer worldwide and its incidence is increasing rapidly. Studies have found that ncRNAs are likely to play a crucial role in a variety of biological processes including the pathogenesis and progression of HCC. In this review, we summarized the regulation mechanism and biological functions of ncRNAs in HCC with respect to its application in HCC diagnosis, therapy and prognosis.

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Aflatoxin B1 Promotes Cell Growth and Invasion in Hepatocellular Carcinoma HepG2 Cells through H19 and E2F1

Cited by 52 publications

References 27 publications

Characteristics of Liver Cancer at Khmer-Soviet Friendship Hospital in Phnom Penh, Cambodia

Characteristics of Liver Cancer at Khmer-Soviet Friendship Hospital in Phnom Penh, Cambodia

The Relationship of Aflatoxin B1 and Hepatocellular Carcinoma: A Mini Review

Non-coding RNAs: New therapeutic targets and opportunities for hepatocellular carcinoma

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