Aflatoxin B1 disrupts blood-testis barrier integrity by reducing junction protein and promoting apoptosis in mice testes

Huang, Wanyue; Liu, Meilin; Xiao, Bonan; Zhang, Jian; Song, Miao; Li, Yanfei; Cao, Zheng

doi:10.1016/j.fct.2021.111972

Cited by 41 publications

(26 citation statements)

References 52 publications

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“…MAPK signaling pathway is the key mediator that controls the phosphorylation of many downstream effectors, leading to modulate different cellular functions, including cell proliferation, differentiation, and migration ( Joerger-Messerli et al, 2021 ). Oxidative stress-mediated p38 MAPK signaling pathway was associated with the blood-testis barrier-related junction protein and promoting apoptosis in mice testes ( Huang et al, 2021 ). Moreover, activation of the MAPK signaling pathway was involved in the molecular mechanism of apoptosis in spermatogonia cells ( Park et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Low-Dose Radiation Can Cause Epigenetic Alterations Associated With Impairments in Both Male and Female Reproductive Cells

Leung

Yang

et al. 2021

Front. Genet.

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Humans are regularly and continuously exposed to ionizing radiation from both natural and artificial sources. Cumulating evidence shows adverse effects of ionizing radiation on both male and female reproductive systems, including reduction of testis weight and sperm count and reduction of female germ cells and premature ovarian failure. While most of the observed effects were caused by DNA damage and disturbance of DNA repairment, ionizing radiation may also alter DNA methylation, histone, and chromatin modification, leading to epigenetic changes and transgenerational effects. However, the molecular mechanisms underlying the epigenetic changes and transgenerational reproductive impairment induced by low-dose radiation remain largely unknown. In this study, two different types of human ovarian cells and two different types of testicular cells were exposed to low dose of ionizing radiation, followed by bioinformatics analysis (including gene ontology functional analysis and Ingenuity Pathway Analysis), to unravel and compare epigenetic effects and pathway changes in male and female reproductive cells induced by ionizing radiation. Our findings showed that the radiation could alter the expression of gene cluster related to DNA damage responses through the control of MYC. Furthermore, ionizing radiation could lead to gender-specific reproductive impairment through deregulation of different gene networks. More importantly, the observed epigenetic modifications induced by ionizing radiation are mediated through the alteration of chromatin remodeling and telomere function. This study, for the first time, demonstrated that ionizing radiation may alter the epigenome of germ cells, leading to transgenerational reproductive impairments, and correspondingly call for research in this new emerging area which remains almost unknown.

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Section: Discussionmentioning

confidence: 99%

Low-Dose Radiation Can Cause Epigenetic Alterations Associated With Impairments in Both Male and Female Reproductive Cells

Leung

Yang

et al. 2021

Front. Genet.

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“…Our study indicated that T-2 toxin caused structural damage and osteogenesis dysfunction along with oxidative stress in mouse femur. Oxidative stress is the pathological mechanism of many mycotoxins, 30,31 and involved in bone pathogenesis including osteoporosis, arthritis, diabetes-induced bone complications, and other [32][33][34] In this study, T-2 toxin exposure increased ROS generation and lipid peroxidation, but decreased the activity of T-AOC in mouse femur. On the one hand, ROS directly inhibits osteoblast function.…”

Section: Discussionmentioning

confidence: 59%

T‐2 toxin‐induced femur lesion is accompanied by autophagy and apoptosis associated with Wnt/β‐catenin signaling in mice

Zhang

Song

Cui

et al. 2022

Environmental Toxicology

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T-2 toxin is one of the most common mycotoxins found in grain foods, animal feed, and other agricultural by-products causing food contamination and health threat. The skeletal system is the main target tissue for T-2 toxin. T-2 toxin exposure is also recognized as a potential contributor to multiple types of bone diseases, including Kashin-Beck disease. However, the mechanisms of T-2 toxin-induced bone toxicity remain unclear. In this study, 60 male C57BL/6 mice were exposed T-2 toxin with 0, 0.5, 1 or 2 mg/kg body weight by intragastric administration for 28 days, respectively. Femora were collected for the detections of femur lesion, bone formation factors, oxidative stress, autophagy, apoptosis, and Wnt/β-catenin signaling. Our research showed that T-2 toxin caused bone formation disorders, presenting as the reduction of the BMD and femur length, bone structure changes and abnormal bone formation proteins expressions, along with enhanced oxidative stress. Meanwhile, T-2 toxin increased expressions of autophagy-related proteins (Beclin 1, ATG5, p62, and LC3), and promoted apoptosis in mouse femur. Moreover, T-2 toxin suppressed the Wnt/β-catenin signaling and expressions of downstream target genes. Taken together, our data indicated T-2 toxin-induced femur lesion was accompanied by autophagy and apoptosis, which was associated with Wnt/β-catenin signaling.

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“…The presence of EHS was also detected in brain and gonadal tissues, indicating that EHS could cross the blood-brain barrier and blood-testis barrier and increase the risk of neurotoxicity and transgenerational toxicity. 48,49 Similar to gill tissue, skin tissue can also be in direct contact with the exposure solution, while the mucus layer secreted on the skin surface becomes the main resistance to the enrichment of target pollutants, resulting in a lower level of occurrence. 50 Muscle is the tissue with the lowest cumulative concentration of EHS, possibly because EHS is lipophilic and muscle tissue has a low fat content, which leads to a low affinity between EHS and muscle tissue.…”

Section: Resultsmentioning

confidence: 99%

Effects of polystyrene nanoplastics on the bioaccumulation, distribution and parental transfer of ethylhexyl salicylate

Zhou

Yan

et al. 2022

Environ. Sci.: Nano

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Aflatoxin B1 disrupts blood-testis barrier integrity by reducing junction protein and promoting apoptosis in mice testes

Cited by 41 publications

References 52 publications

Low-Dose Radiation Can Cause Epigenetic Alterations Associated With Impairments in Both Male and Female Reproductive Cells

Low-Dose Radiation Can Cause Epigenetic Alterations Associated With Impairments in Both Male and Female Reproductive Cells

T‐2 toxin‐induced femur lesion is accompanied by autophagy and apoptosis associated with Wnt/β‐catenin signaling in mice

Effects of polystyrene nanoplastics on the bioaccumulation, distribution and parental transfer of ethylhexyl salicylate

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