Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians

Jiang, Yi; Jolly, Pauline E.; Ellis, William O.; Wang, Jiasheng; Phillips, Timothy D.; Williams, Jonathan

doi:10.1093/intimm/dxh262

Cited by 217 publications

(133 citation statements)

References 42 publications

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“…Importantly, AFB 1 has also been shown to be an anti-nutritional agent that reduces concentrations of vitamins and proteins in animals and humans (Gong et al 2002;Williams et al 2004;Wild 2007;Tang et al 2009). Further, it is a potent immunotoxic agent in animals and also changes T-cell phenotypes in humans, which may aggravate the burden of infectious diseases in the developing world (Williams et al 2004;Jiang et al 2005;Wild 2007). AF contamination is an important problem in relation to food quality/food safety in Africa as a result of poor production and storage practices for major staples of the African diet (Hell et al 2000;Williams et al 2004Williams et al , 2010Lewis et al 2005).…”

Section: Please Scroll Down For Arti Clementioning

confidence: 99%

Longitudinal evaluation of aflatoxin exposure in two cohorts in south-western Uganda

Kang

Nkurunziza

Muwanika

et al. 2015

Food Additives & Contaminants: Part A

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akes every effort t o ensure t he accuracy of all t he inform at ion ( t he " Cont ent " ) cont ained in t he publicat ions on our plat form . However, Taylor & Francis, our agent s, and our licensors m ake no represent at ions or warrant ies what soever as t o t he accuracy, com plet eness, or suit abilit y for any purpose of t he Cont ent . Any opinions and views expressed in t his publicat ion are t he opinions and views of t he aut hors, and are not t he views of or endorsed by Taylor & Francis. The accuracy of t he Cont ent should not be relied upon and should be independent ly verified wit h prim ary sources of inform at ion. Taylor and Francis shall not be liable for any losses, act ions, claim s, proceedings, dem ands, cost s, expenses, dam ages, and ot her liabilit ies what soever or howsoever caused arising direct ly or indirect ly in connect ion wit h, in relat ion t o or arising out of t he use of t he Cont ent . This art icle m ay be used for research, t eaching, and privat e st udy purposes. Any subst ant ial or syst em at ic reproduct ion, redist ribut ion, reselling, loan, sub-licensing, syst em at ic supply, or dist ribut ion in any form t o anyone is expressly forbidden. Term s & Condit ions of access and use can be found at ht t p: / / www.t andfonline.com / page/ t erm s-and-condit ions Aflatoxins (AF) are a group of mycotoxins. AF exposure causes acute and chronic adverse health effects such as aflatoxicosis and hepatocellular carcinoma in human populations, especially in the developing world. In this study, AF exposure was evaluated using archived serum samples from human immunodeficiency virus (HIV)-seronegative participants from two cohort studies in south-western Uganda. AFB 1 -lysine (AFB-Lys) adduct levels were determined via HPLC fluorescence in a total of 713 serum samples from the General Population Cohort (GPC), covering eight time periods between 1989 and 2010. Overall, 90% (642/713) of the samples were positive for AFB-Lys and the median level was 1.58 pg mg −1 albumin (range = 0.40-168 pg mg −1 albumin). AFB-Lys adduct levels were also measured in a total of 374 serum samples from the Rakai Community Cohort Study (RCCS), across four time periods between 1999 and 2003. The averaged detection rate was 92.5% (346/374) and the median level was 1.18 pg mg −1 albumin (range = 0.40-122.5 pg mg −1 albumin). In the GPC study there were no statistically significant differences between demographic parameters, such as age, sex and level of education, and levels of serum AFB-Lys adduct. In the RCCS study, longitudinal analysis using generalised estimating equations revealed significant differences between the adduct levels and residential areas (p = 0.05) and occupations (p = 0.02). This study indicates that AF exposure in people in two populations in south-western Uganda is persistent and has not significantly changed over time. Data from one study, but not the other, indicated that agriculture workers and rural area residents had more AF exposure than those non-agricultural workers and non...

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confidence: 99%

Longitudinal evaluation of aflatoxin exposure in two cohorts in south-western Uganda

Kang

Nkurunziza

Muwanika

et al. 2015

Food Additives & Contaminants: Part A

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“…(Giorni et al, 2007;Passone et al, 2010). These AFs are toxic and their main adverse effects on humans are hepatocarcinoma (Qian et al, 1994; IARC, 2014), immune system deficiency (Jiang et al, 2005), reduced child growth (Gong et al, 2004) and increased risks of stillborn or newborn jaundice (Shuaib et al, 2010). To reduce those multiple effects, many countries have implemented maximum authorized levels of AFs in food and feed (Wu & Guclu, 2012).…”

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Reduction of aflatoxin production by Aspergillus flavus and Aspergillus parasiticus in interaction with Streptomyces

et al. 2015

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The aim of this study is to investigate aflatoxin gene expression during Streptomyces-Aspergillus interaction. Aflatoxins are carcinogenic compounds produced mainly by Aspergillus flavus and Aspergillus parasiticus. A previous study has shown that Streptomyces-A. flavus interaction can reduce aflatoxin content in vitro. Here, we first validated this same effect in the interaction with A. parasiticus. Moreover, we showed that growth reduction and aflatoxin content were correlated in A. parasiticus but not in A. flavus. Secondly, we investigated the mechanisms of action by reversetranscriptase quantitative PCR. As microbial interaction can lead to variations in expression of household genes, the most stable [act1, btub (and cox5 for A. parasiticus)] were chosen using geNorm software. To shed light on the mechanisms involved, we studied during the interaction the expression of five genes (aflD, aflM, aflP, aflR and aflS). Overall, the results of aflatoxin gene expression showed that Streptomyces repressed gene expression to a greater level in A. parasiticus than in A. flavus. Expression of aflR and aflS was generally repressed in both Aspergillus species. Expression of aflM was repressed and was correlated with aflatoxin B1 content. The results suggest that aflM expression could be a potential aflatoxin indicator in Streptomyces species interactions. Therefore, we demonstrate that Streptomyces can reduce aflatoxin production by both Aspergillus species and that this effect can be correlated with the repression of aflM expression. INTRODUCTIONAflatoxins (AFs) are polyketide-derived furanocoumarins. They are produced by fungi of the genus Aspergillus (including Aspergillus flavus and Aspergillus parasiticus) in agricultural foodstuffs (maize, hazelnut, peanut, etc.) (Giorni et al., 2007;Passone et al., 2010). These AFs are toxic and their main adverse effects on humans are hepatocarcinoma (Qian et al., 1994; IARC, 2014), immune system deficiency (Jiang et al., 2005), reduced child growth (Gong et al., 2004) and increased risks of stillborn or newborn jaundice (Shuaib et al., 2010). To reduce those multiple effects, many countries have implemented maximum authorized levels of AFs in food and feed (Wu & Guclu, 2012). AF biosynthesis is coded by a 80 kb long DNA sequence. The latter is a cluster containing 30 putative genes characterized in both A. flavus and A. parasiticus (Yu, 2012). For structural genes, early (as aflD), medium (as aflM) and late (as aflP) genes are denominated (Fig. S1, available in the online Supplementary Material). The gene aflD encodes a reductase enzyme involved in the conversion of norsolorinic acid to averantin (Papa, 1982); aflM is required for the conversion of versicolorin A to demethylsterigmatocystin (Skory et al., 1992); and aflP encodes a methyltransferase converting sterigmatocystin to O-methylsterigmatocystin (Bhatnagar et al., 1988). Two cluster-specific regulators are also known: aflR encodes a transcription activator that binds a consensus sequence in the promoter regions of AF ...

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“…Several studies have suggested the potential of aflatoxin to play suppressive roles on the immune function, increasing susceptibility to infectious diseases or reactivating chronic infections, and decreasing vaccine and drug efficacy (Berek et al 2001;Turner et al 2003;Jiang et al 2005Jiang et al , 2008Oswald et al 2005). Specifically, recent studies conducted in Ghana and…”

Section: Nutrition and Health Implicationsmentioning

confidence: 99%

Achieving a nutrition revolution for Africa: The road to healthier diets and optimal nutrition

Ayalew¹,

Hoffmann²,

Lindahl³

et al. 2016

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Focusing the 2015 Annual Trends and Outlook Report (ATOR) on nutrition will contribute to a broader understanding of the critical role of nutrition in achieving international, continental, and national economic growth targets through agriculture, food security, and nutrition. This report presents information and analysis in support of evidence-based policy making that should inform the second generation of CAADP national investment plans now being developed. This is an important moment for shaping the region’s future and ensuring that the much-needed agriculture-led growth and development agenda can simultaneously deliver on improving nutrition, saving lives, improving productivity and health, and curbing nutrition-related diseases and the associated public health expenditures. These investment plans should address not only the usual elements of undernutrition but also widespread micronutrient deficiencies (termed “hidden hunger”) and the growing problem of overweight and obesity that is associated with economic growth.1 introduction 2 The African union policy environment toward enabling action for nutrition in Africa 3 Africa’s progress toward meeting current nutrition targets 4 Economic development and nutrition transition in Ghana: taking stock of food consumption patterns and trends 5 Making African agriculture and food systems work for nutrition: what has been done, and what needs to be done? 6 Lessons learned from the evaluation of Helen Keller International’s enhanced homestead food production program 7 The role of biofortification as part of more diverse diets in Africa: progress, challenges, and opportunities 8 The role of mycotoxin contamination in nutrition: the aflatoxin story 9 The challenges, opportunities, and lessons learned in evidence-informed decision making in Africa 10 Evaluating nutrition-sensitive programs: challenges, methods, and opportunities 11 Supporting multisectoral action: capacity and nutrition leadership challenges facing Africa 12 Tracking key CAADP indicators and implementation processes 13 Summary and policy recommendations: toward a nutrition revolution for AfricaReportPRIFPRI1; ReSAKSS; HarvestPlus; B Promoting healthy food systemsDSGD; WCAO; ESAO; HarvestPlus; PHND; A4NH; MTIDCGIAR Research Program on Agriculture for Nutrition and Health (A4NH

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Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians

Cited by 217 publications

References 42 publications

Longitudinal evaluation of aflatoxin exposure in two cohorts in south-western Uganda

Longitudinal evaluation of aflatoxin exposure in two cohorts in south-western Uganda

Reduction of aflatoxin production by Aspergillus flavus and Aspergillus parasiticus in interaction with Streptomyces

Achieving a nutrition revolution for Africa: The road to healthier diets and optimal nutrition

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