Affinity binding of aptamers to agarose with DNA tetrahedron for removal of hepatitis B virus surface antigen

Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering

“…Agarose-based hydrogels have considerably been utilized in the investigation of mechanical load reaction for chondrocytes and mesenchymal stem cells (MSCs) [22]. Agarose has acquired a wide range of applications such as drug delivery [23,24], cancer therapy [25,26], tissue engineering and regenerative medicine [27][28][29][30], and disease diagnosis, controlling, and treatment [31][32][33]. It has been utilized in various tissue engineering applications, including the neural system [34], bone formation [35], cardiac regeneration, wound healing, and attachment to tissues such as skin [36], brain [37], and cornea.…”

A critical review of hemoperfusion adsorbents: materials, functionalization and matrix structure selection

“…89 DNA nanostructures can be an effective intermediate for immobilizing biomolecules due to their high level of controllability and flexibility to create desired finely nanostructures through precision "bottom-up" assembly. 90 Accordingly, a novel nucleic acid-based ligand, aptamers, attracted wide attention for its high specificity and stability under physiological conditions compared to protein-based ligands 91 . Aptamers with specific structures could be selected or designed by computers and synthesized with high reproducibility…”

Engineering surface patterns on nanoparticles: new insights into nano-bio interactions

“…Compared with a single ligand, the whole nanoparticle has a stronger binding capacity for the surface protein of the virus capsid after the ligand is connected to the DNA structure. 292 However, the distribution pattern of surface proteins of some viruses is complex, which hinders the interaction of nanoparticles with surface proteins and thus affects the recognition. 293,294 Therefore, it is of great significance to finely regulate the distribution of ligands in DNA structures and explore their ability to recognise viruses.…”