Afferent modulation of dopamine neuron firing patterns

Kitai, S.T.; Shepard, Paul D.; Callaway, Joseph C.; Scroggs, Reese S.

doi:10.1016/s0959-4388(99)00040-9

Cited by 209 publications

(194 citation statements)

References 97 publications

Supporting

Mentioning

185

Contrasting

Order By: Relevance

“…Our study provides evidence that DA midbrain subpopulations significantly diverge from a single electrophysiological phenotype (Kitai et al, 1999). We identified differences in I h current expressed as significant differences in I h charge densities as an important mechanism responsible for functional diversity of DA neurons.…”

Section: Functional Diversity Of Anatomically and Neurochemically Idementioning

confidence: 62%

“…Second, I h channels are directly modulated by cyclic nucleotides (Wainger et al, 2001) and thus are potential targets of many signaling cascades that control cyclic nucleotide levels in neurons (Pape, 1996;Luthi and McCormick, 1999;Budde et al, 2000). Thus, SN/CBϪ neurons are likely to be particularly sensitive to neuromodulatory input by for instance, serotonin (Nedergaard et al, 1991;Kitai et al, 1999).…”

Section: Functional Diversity Of Anatomically and Neurochemically Idementioning

confidence: 99%

See 1 more Smart Citation

I_hChannels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain

et al. 2002

View full text Add to dashboard Cite

Dopaminergic (DA) midbrain neurons in the substantia nigra (SN) and ventral tegmental area (VTA) are involved in various brain functions such as voluntary movement and reward and are targets in disorders such as Parkinson's disease and schizophrenia. To study the functional properties of identified DA neurons in mouse midbrain slices, we combined patchclamp recordings with either neurobiotin cell-filling and triple labeling confocal immunohistochemistry, or single-cell RT-PCR. We discriminated four DA subpopulations based on anatomical and neurochemical differences: two calbindin D 28 -k (CB)-expressing DA populations in the substantia nigra (SN/CBϩ) or ventral tegmental area (VTA/CBϩ), and respectively, two calbindin D 28 -k negative DA populations (SN/CBϪ, VTA/CBϪ). VTA/ CBϩ DA neurons displayed significantly faster pacemaker frequencies with smaller afterhyperpolarizations compared with other DA neurons. In contrast, all four DA populations possessed significant differences in I h channel densities and I h channel-mediated functional properties like sag amplitudes and rebound delays in the following order: SN/CBϪ 3 VTA/ CBϪ 3 SN/CBϩ 3 VTA/CBϩ. Single-cell RT-multiplex PCR experiments demonstrated that differential calbindin but not calretinin expression is associated with differential I h channel densities. Only in SN/CBϪ DA neurons, however, I h channels were actively involved in pacemaker frequency control. In conclusion, diversity within the DA system is not restricted to distinct axonal projections and differences in synaptic connectivity, but also involves differences in postsynaptic conductances between neurochemically and topographically distinct DA neurons.

show abstract

Section: Functional Diversity Of Anatomically and Neurochemically Idementioning

confidence: 62%

Section: Functional Diversity Of Anatomically and Neurochemically Idementioning

confidence: 99%

I_hChannels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain

et al. 2002

View full text Add to dashboard Cite

show abstract

“…This idea is supported by the observation that the PPTg provides robust monosynaptic excitatory input to these neurons, and input involves both glutamate and ACh [152][153][154][155][156][157]. Thus, it is reasonable to hypothesize that fast transmission of information from the PPTg to mesencephalic dopamine neurons occurs in response to behavioral stimuli.…”

Section: The Role Of the Pptg In Predictive Reward Information And Rementioning

confidence: 97%

Participation of the pedunculopontine tegmental nucleus in arousal-demanding functions

Vitale¹,

Capozzo²,

Mazzone³

et al. 2017

Transl Brain Rhythmicity

View full text Add to dashboard Cite

The pedunculopontine tegmental nucleus (PPTg) is part of the locomotor mesencephalic region and the reticular activating system (RAS). As such, it is involved in regulating some aspects of the motor control and the wake/sleep cycle, but the way in which it operates is unclear. PPTg neurons respond to a variety of sensory stimuli and to cues that trigger the execution of goal-directed motor acts. In this paper, we discuss data that suggest that in addition to operating via thalamic nuclei, the PPTg may also operate by activating cerebellar nuclei, especially the dentate nucleus. In such a way, an intense and diffuse activation of the cerebral cortex may be achieved. In arousal-demanding reward-related tasks, separate populations of PPTg neurons modulate their discharge pattern to encode, in particular, expectancy and magnitude of reward. These neuronal responses, which should reach thalamic, basal ganglia, and cerebellar nuclei through ascending PPTg fibers are essential for the formation of stimuli-reward associations and action selection. In parallel, PPTg neurons, via descending fibers directed to lower brainstem and spinal motor structures, may automatically influence motor mechanisms and muscle tone in order to cause movements that are executed in a smooth and timely manner. In patients affected by Parkinson's disease, PPTg deep brain stimulation may increase arousal, thus making patients more attentive to behavioral stimuli that trigger motor act, while simultaneously facilitating movement.

show abstract

“…The dopaminergics neurons of the midbrain are important to voluntary movement, working memory and recompense system. Problems in its structure may cause motor disorders associated with Parkinsonism, also esquizophreny and attention deficit that can be caused by drugs abuse, including alcohol (Goldman-Rakic, 1999; Kitai et al, 1999;Spanagel & Weiss, 1999;Dunnet & Bjorklund, 1999;Verhoeff, 1999;Berke & Hyman, 2000;Grace, 2000;Svensson, 2000;Tzschentke, 2001;Korotkova et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Study of Acute Effects of Ethanol on Midbrain of Wistar Rats Associated with the Date of Birth of Neurons in Encephalon

et al. 2009

View full text Add to dashboard Cite

SUMMARY:The verification of the acute effects of ethanol on the midbrain, which neurons are mainly formed in E14, will ratify if the acute effects of ethanol are associated, in terms of prevalence, to the date of birth of neurons in certain regions of the brain. The aim of this study was to determine the effects of acute exposure to ethanol on the neuronal density of the midbrain and to associate these results with acute effects of ethanol in other regions of the brain under the same conditions. The rats were treated with intraperitoneal ethanol during one day (E12) and 1h after the last ethanol injection was applied to BrdU. The animals were sacrificed; the brains were removed and sectioned. The sections were treated with DAB for the BrdU revelation, the slides were stained with safranin for one group and another group was stained with H & E. The effects of acute injection of ethanol in E12 on the midbrain were not detected in this study. Data from literature suggest that the deleterious action of acute ethanol consumption only occur if the drug is injected at times near the beginning of the migration of neurons in that particular region of the brain.

show abstract

Afferent modulation of dopamine neuron firing patterns

Cited by 209 publications

References 97 publications

I_hChannels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain

I_hChannels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain

Participation of the pedunculopontine tegmental nucleus in arousal-demanding functions

Immunohistochemical Study of Acute Effects of Ethanol on Midbrain of Wistar Rats Associated with the Date of Birth of Neurons in Encephalon

Contact Info

Product

Resources

About

Afferent modulation of dopamine neuron firing patterns

Cited by 209 publications

References 97 publications

IhChannels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain

IhChannels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain

Participation of the pedunculopontine tegmental nucleus in arousal-demanding functions

Immunohistochemical Study of Acute Effects of Ethanol on Midbrain of Wistar Rats Associated with the Date of Birth of Neurons in Encephalon

Contact Info

Product

Resources

About

I_hChannels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain

I_hChannels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain