Afferent Connexions of the Paramedian Reticular Nucleus of the Medulla Oblongata in the Cat

Brodal, Alf; Gogstad, Anders Chr.

doi:10.1159/000141194

Cited by 58 publications

(11 citation statements)

References 3 publications

(3 reference statements)

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“…Termination of spinal afferents in the paramedian reticular nucleus has previously been reported in the cat by Brodal and Gogstad [1957], and in the nuclei pontis of the same animal by Walberg and Brodal [1953].…”

Section: Discussionmentioning

confidence: 58%

The Topographical Projection of Fibres from the Anterolateral Quadrant of the Spinal Cord to the Subdiencephalic Brain Stem in Man

Bowsher¹

1962

Eur Neurol

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Section: Discussionmentioning

confidence: 58%

The Topographical Projection of Fibres from the Anterolateral Quadrant of the Spinal Cord to the Subdiencephalic Brain Stem in Man

Bowsher¹

1962

Eur Neurol

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“…The role of the paramedian reticular nuclei of the medulla (Brodal, 1953) in the fastigial pressor response is not clear. Brodal & Torvik (1954) and Brodal & Gogstad (1957) have identified the fibre connexions between the paramedian nuclei, the fastigial nuclei and the vermian cerebellum. Miura & Reis (1969) report that the response is abolished by bilateral destruction of the paramedian nuclei.…”

Section: Fastigial Stimulationmentioning

confidence: 99%

Autonomic effector responses to stimulation of nucleus fastigius

Achari¹,

Downman²

1970

The Journal of Physiology

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SUMMARY1. In anaesthetized cats electrical stimulation of the nucleus fastigius caused cardiovascular responses, electrodermal responses of the paws and pupil dilation with retraction of the nictitating membranes.2. The cardiovascular responses included rise of arterial pressure and peripheral vasoconstriction. Increase ofpulse pressure and tachycardia also occurred.3. The effects of sympathetic blocking drugs indicate that fastigial stimulation causes sympathetic discharge to the heart and to the peripheral vessels. There was no evidence of alteration of vagal activity.4. Fastigial stimulation inhibited reflex bradyeardia due to carotid sinus distension, vagal afferent stimulation or phenyl diguanide.5. Fastigial and hypothalamic influences on cardiovascular responses could be evoked after severing the nervous pathways connecting the two.6. The pressor response to fastigial stimulation was still present after bilateral division of the carotid sinus and vagus nerves.

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“…Cytoarchitectonically three subnuclear groups have been defined (Brodal 1953;Brodal and Torvik 1954;Brodal and Gogstad 1957): (1) n. reticularis paramedianus pars ventralis (PRNv), (2) pars dorsalis (PRNd), (3) pars accessorius (PRNacc).…”

Section: The Paramedian Reticular Nucleimentioning

confidence: 99%

“…The PRN receives fibers from the spinal cord (Brodal and Gogstad 1957;Mehler et al 1960;Mehler 1969), dorsal column nuclei (Brodal and Gostad 1957), vestibular nuclei (Ladpli and Brodal 1968), fastigial nuclei of the cerebellum (Thomas et al 1956;Walberg et al 1962); somatosensory cerebral cortex (Brodal and Gogstad 1957;SousaPinto 1970), and the macula (Ghelarducci et al 1974). All subnuclei of the PRN project to the cranial and caudal vermis of the cerebellum (Brodal and Torvik 1954;Somana and Walberg 1978).…”

Section: The Paramedian Reticular Nucleimentioning

confidence: 99%

Arteether-induced brain injury in Macaca mulatta . I. The precerebellar nuclei: the lateral reticular nuclei, paramedian reticular nuclei, and perihypoglossal nuclei

Petras

Young

Bauman

et al. 2000

Anatomy and Embryology

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Malaria poses a threat across several continents: Eurasia (Asia and parts of Eastern Europe), Africa, Central and South America. Bradley (1991) estimates human exposure at 2,073,000,000 with infection rates at 270,000,000, illnesses at 110,000,000, and deaths at 1,000,000. Significant mortality rates are attributed to infection by the parasite Plasmodium falciparum, with an estimated 90% among African children. A worldwide effort is ongoing to chemically and pharmacologically characterize a class of artemisinin compounds that might be promising antimalarial drugs. The U.S. Army is studying the efficacy and toxicity of several artemisinin semi-synthetic compounds: arteether, artemether, artelinic acid, and artesunate. The World Health Organization and the U.S. Army selected arteether for drug development and possible use in the emergency therapy of acute, severe malaria. Male Rhesus monkeys (Macaca mulatta) were administered different daily doses of arteether, or the vehicle alone (sesame oil), for a period of either 14 days, or 7 days. Neuropathological lesions were found in 14-day arteether treated monkeys in the precerebellar nuclei of the medulla oblongata, namely: (1) the lateral reticular nuclei (subnuclei magnocellularis, parvicellularis, and subtrigeminalis), (2) the paramedian reticular nuclei (subnuclei accessorius, dorsalis, and ventralis), and the perihypoglossal nuclei (n. intercalatus of Staderini, n. of Roller, n. prepositus hypoglossi). The data demonstrate that the simina meduallry precerebellar nuclei have a high degree of vulnerability when arteether is given for 14 days at dose levels between 8mg/kg per day and 24 mg/kg per day. The neurological consequences of this treatment regimen could profoundly impair posture, gait, and autonomic regulation, while eye movement disorders might also be anticipated.

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Afferent Connexions of the Paramedian Reticular Nucleus of the Medulla Oblongata in the Cat

Cited by 58 publications

References 3 publications

The Topographical Projection of Fibres from the Anterolateral Quadrant of the Spinal Cord to the Subdiencephalic Brain Stem in Man

The Topographical Projection of Fibres from the Anterolateral Quadrant of the Spinal Cord to the Subdiencephalic Brain Stem in Man

Autonomic effector responses to stimulation of nucleus fastigius

Arteether-induced brain injury in Macaca mulatta . I. The precerebellar nuclei: the lateral reticular nuclei, paramedian reticular nuclei, and perihypoglossal nuclei

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