“…While these factors are important for QOL, one area that has received less attention is psychological symptoms and coping, despite higher rates of psychological symptoms within CD patients compared to the general population (16,(31)(32)(33)(34)(35)(36). Two studies found that increased depression and anxiety in CD were correlated with reduced QOL (16,36), while a recent study found that emotion-oriented coping was negatively related to QOL (37). In the broader context, the link between QOL, psychopathology, and coping is well established (38)(39)(40)(41)(42), with depression representing the greatest threat to QOL across a range of populations (38).…”