Aetiology of PCR negative suspected Crimean-Congo hemorrhagic fever cases in an endemic area

Tanyel, Esra; Sünbül, Mustafa; Fletcher, Tom; Leblebicioğlu, Hakan

doi:10.1080/20477724.2016.1213958

Cited by 7 publications

(5 citation statements)

References 19 publications

(21 reference statements)

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“…[9] According to the data of the Turkish Ministry of Health, cases were most prevalent in the provinces of Tokat, Yozgat, Sivas, Erzurum, Çorum, Erzincan, and Artvin in 2002-2003, but cases began to emerge nationwide in 2017. [10] However, the disease remains endemic, mainly in the Northeastern Anatolian region of Turkey (Tokat, Amasya, Sivas, Gümühane, Yozgat, and Çorum). [11] According to a bibliometric analysis of CCHF by Dereli et al, [12] Cumhuriyet University conducted the most studies, 54 (3.6%) of the 1,480 research studies in Turkey, followed by Ankara Numune Training and Research Hospital with 49 (3.3%) studies, and Karadeniz Technical University and Bozok University in third and fourth place, respectively.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of scientific research on Crimean-Congo hemorrhagic fever in Turkey

Çevıker

Yılmaz²,

Uyar³

et al. 2021

D J Med Sci

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Objectives: Since the first case of Crimean-Congo hemorrhagic fever (CCHF) was detected in our country in 2002, the number of cases has been steadily increasing. The purpose of this study is to evaluate and provide a bibliographic review of national literature studies on this endemic and life-threatening disease in our country and conduct content analysis to guide future studies. Materials and methods: In this study, an investigation was conducted using the website TR Dizin, one of our national databases. Between 1960 and 2019, the keywords 'Crimean-Congo hemorrhagic fever' and 'KKKA' were used to search for publications in scientific databases in the medical subject category. Only 41 research articles were included in the study out of a total of 101 that were accessed. Bibliographic analysis was carried on the studies. Results: A total of 41 publications were analyzed in this study. The most scientific articles (43.9%) were detected between 2011and 2015. Ankara, Erzurum, Istanbul, and Sivas were the most commonly studied provinces; one study was conducted in two provinces (Kırşehir and Ankara) and two studies were conducted abroad (Cyprus and Iran). The majority of the papers were retrospective studies with patient samples, written in Turkish The number of cases in the sample ranged from 8 to 1,250 cases. Five of the studies (12.2%) were conducted in the pediatric age group. The rate of publications in the Web of Science (WOS) indexed journals was 46.3%. While 21 (51.2%) of the publications were cited, 13 of them were found in the WOS index. According to content analysis of the publications, demographic characteristics, epidemiological examination (36.6%) and clinical features (31.7%) were the most investigated. Conclusion: It is critical to expand the number of CCHF studies published in our country and to establish research methodologies, particularly molecular investigation, for epidemic treatment and control.

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Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of scientific research on Crimean-Congo hemorrhagic fever in Turkey

Çevıker

Yılmaz²,

Uyar³

et al. 2021

D J Med Sci

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“…As a result, it has been suggested that the burden of CCHF disease is greater than estimated from official case reports ( 99 , 100 ). Asymptomatic infections may be common and mild disease can present as non-specific febrile symptoms ( 101 ). The awareness of CCHF disease and symptoms is low among physicians and veterinarians even in endemic countries ( 102 ), and increasing the awareness of CCHF clinical symptoms among physicians and veterinarians is the first step towards improving access to diagnosis for mild cases, and to prevent nosocomial outbreaks ( 103 ).…”

Section: Controlling Zoonotic Transmission Of Cchfvmentioning

confidence: 99%

The Integration of Human and Veterinary Studies for Better Understanding and Management of Crimean-Congo Haemorrhagic Fever

et al. 2021

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Outbreaks that occur as a result of zoonotic spillover from an animal reservoir continue to highlight the importance of studying the disease interface between species. One Health approaches recognise the interdependence of human and animal health and the environmental interplay. Improving the understanding and prevention of zoonotic diseases may be achieved through greater consideration of these relationships, potentially leading to better health outcomes across species. In this review, special emphasis is given on the emerging and outbreak pathogen Crimean-Congo Haemorrhagic Fever virus (CCHFV) that can cause severe disease in humans. We discuss the efforts undertaken to better understand CCHF and the importance of integrating veterinary and human research for this pathogen. Furthermore, we consider the use of closely related nairoviruses to model human disease caused by CCHFV. We discuss intervention approaches with potential application for managing CCHFV spread, and how this concept may benefit both animal and human health.

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“…We detected elevations in thrombocytopenia, leukopenia, CK, and D-dimer levels in our CCHF group, as well as reduced levels of fibrinogen. However, these laboratory findings are known to be non-specific for CCHF (14). There is need for an easy, inexpensive, and perfect single biomarker for the diagnosis, follow-up, and prognosis of diseases like CCHF, and studies have been conducted to search for this type of biomarker (15,16).…”

Section: E a R L Ymentioning

confidence: 99%

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

Küçükceran

Karaşahin

Delice

et al. 2021

Düzce Tıp Fakültesi Dergisi

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Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor (urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed on various cell types. Previous literature shows that the amount of soluble urokinase-type plasminogen activator receptor (suPAR) secreted from affected cells is higher in Crimean-Congo hemorrhagic fever (CCHF) patients than in healthy controls. Thus, we aimed to investigate the diagnostic value of suPAR in the differential diagnosis of CCHF in emergency services. Material and Methods: Individuals over 16 years old with a preliminary diagnosis of CCHF disease were divided into two groups as real time-polymerase chain reaction (RT-PCR) and/or IgM positive (CCHF group) and RT-PCR and/or IgM negative (control group). Results: Eighty patients were included in this study. Forty patients with CCHF virus PCR and/or CCHF virus IgM were identified as CCHF group and 40 patients included as negative control group. The median age of the patients was 45 (range, 16-91) years, and 49 patients (61.3%) were male. Leukocyte, platelet, and fibrinogen levels were significantly lower, while creatinine kinase, aPTT, and D-dimer levels were significantly higher in CCHF group. There was no statistically significant difference between the control group and CCHF group for SuPAR (p=0.386). In addition, control group patients not diagnosed with CCHF were examined, brucellosis, influenza, and pneumonia were found to be the most common. Conclusion: The use of suPAR as a biomarker in the differentiation of patients with similar findings in emergency services was investigated and found to have no diagnostic value.

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Aetiology of PCR negative suspected Crimean-Congo hemorrhagic fever cases in an endemic area

Cited by 7 publications

References 19 publications

Bibliometric analysis of scientific research on Crimean-Congo hemorrhagic fever in Turkey

Bibliometric analysis of scientific research on Crimean-Congo hemorrhagic fever in Turkey

The Integration of Human and Veterinary Studies for Better Understanding and Management of Crimean-Congo Haemorrhagic Fever

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

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