Aetiology and antifungal susceptibility of yeast bloodstream infections in a Hungarian university hospital between 1996 and 2000

Dóczi, Ilona; Dósa, Erika; Hajdú, Edit; Nagy, Elisabeth

doi:10.1099/0022-1317-51-8-677

Cited by 34 publications

(19 citation statements)

References 19 publications

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“…The incidence rate is similar to previous Hungarian data and results from other European centers [20,21,22]. The decrease in incidence during the last study year may be explained by the administration of prophylactic antifungal therapy by clinicians after the problem of increasing rates of Candida BSI was detected.…”

Section: Discussionsupporting

confidence: 76%

Significance of yeasts in bloodstream infection: Epidemiology and predisposing factors of Candidaemia in adult patients at a university hospital (2010–2014)

Pongrácz

Juhász

Iván

et al. 2015

Acta Microbiologica et Immunologica Hungarica

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The incidence of Candida bloodstream infection (BSI) has increased during the past decades. Species distribution is changing worldwide, and non-albicans Candida spp. are becoming more prevalent. Acquired resistance to antifungal agents has been documented in several reports. The aim of our study was to assess the epidemiology and antifungal susceptibility of Candida isolates from BSI at our institute. The incidence of Candida BSI increased during the fi rst four years of our investigation, from 1.7 to 3.5 episodes / 10 000 admissions, then dropped to 2.66 episodes / 10 000 admissions in the last year. The most frequently isolated species was C. albicans (63%), followed by C. glabrata (13%), C. parapsilosis (10.2%), C. tropicalis (9.3%), and C. krusei (3.7%). One isolate each of C. kefyr, C. fabianii and C. inconspicua were detected. The percentage of C. albicans remained stable throughout the study period. The most frequent risk factors of Candida BSI in our patient population were intensive care treatment (60.4%), abdominal surgery (52.5%), and solid malignancy (30.7%). All isolates were wild-type organisms, no acquired antifungal resistance was detected.

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Section: Discussionsupporting

confidence: 76%

Significance of yeasts in bloodstream infection: Epidemiology and predisposing factors of Candidaemia in adult patients at a university hospital (2010–2014)

Pongrácz

Juhász

Iván

et al. 2015

Acta Microbiologica et Immunologica Hungarica

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“…The severity of candidemia is confirmed by the high crude mortality rate found in the European Confederation of Medical Mycology (ECMM) survey (38%) (37)(38)(39), as well as in Finland (35%) (40) and in the Barcelona area (44%) (8). In our series, patients with candidemia had a crude 30-day mortality rate of 39.9%.…”

Section: Discussionsupporting

confidence: 58%

Epidemiology, Species Distribution, Antifungal Susceptibility, and Outcome of Candidemia across Five Sites in Italy and Spain

et al. 2013

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Candidemia has become an important bloodstream infection that is frequently associated with high rates of mortality and morbidity, and its growing incidence is related to complex medical and surgical procedures. We conducted a multicenter study in five tertiary care teaching hospitals in Italy and Spain and evaluated the epidemiology, species distribution, antifungal susceptibilities, and outcomes of candidemia episodes. In the period of 2008 to 2010, 995 episodes of candidemia were identified in these hospitals. The overall incidence of candidemia was 1.55 cases per 1,000 admissions and remained stable during the 3-year analysis. Candida albicans was the leading agent of infection (58.4%), followed by Candida parapsilosis complex (19.5%), Candida tropicalis (9.3%), and Candida glabrata (8.3%). The majority of the candidemia episodes were found in the internal medicine department (49.6%), followed by the surgical ward, the intensive care unit (ICU), and the hemato-oncology ward. Out of 955 patients who were eligible for evaluation, 381 (39.9%) died within 30 days from the onset of candidemia. Important differences in the 30-day mortality rates were noted between institutions: the lowest mortality rate was in the Barcelona hospital, and the highest rate was in the Udine hospital (33.6% versus 51%, respectively; P ‫؍‬ 0.0005). Overall, 5.1% of the 955 isolates tested were resistant or susceptible dose dependent (SDD) to fluconazole, with minor differences between the hospitals in Italy and Spain (5.7% versus 3.5%, respectively; P ‫؍‬ 0.2). Higher MICs for caspofungin were found, especially with C. parapsilosis complex (MIC 90 , 1 g/ml). Amphotericin B had the lowest MICs. This report shows that candidemia is a significant source of morbidity in Europe, causing a substantial burden of disease and mortality.

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“…The average fre- quency of candidaemia episodes in our university, 0.41 per 10,000 patient days, was lower than the corresponding data reported from Spain (0.73), Italy (0.90) and Ireland (0.70), but similar to that observed in a European survey (0.44) [4,5,21,22]. The most frequent causative agent each year was C. albicans, as reported similarly from other countries both inside and outside Europe [6,11,19,20,[22][23][24]. The most frequent causative agent each year was C. albicans, as reported similarly from other countries both inside and outside Europe [6,11,19,20,[22][23][24].…”

Section: Discussionsupporting

confidence: 59%

Evaluation of fungaemia infections in a Hungarian university hospital between 1996 and 2009

Dóczi

Pető

Fodor

et al. 2012

Acta Microbiologica Et Immunologica Hungarica

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The incidence of Candida species causing bloodstream infections in the University Hospital of Szeged, Hungary, between 1996 and 2009, and the susceptibilities of these isolates to antifungal agents were evaluated.Automated blood culture systems (Vital, bioMérieux, Marcy-l'Etoile, France; and BACTEC 9120, Becton-Dickinson Diagnostic Systems, Sparks, USA) were used. The in vitro susceptibilities of the yeast isolates to antifungal agents were determined by the Etest method (AB Biodisk, Solna, Sweden).Bloodstream infections were caused by yeast strains in 231 cases during this period, and 226 Candida strains were cultured from 216 candidaemia patients. Bloodstream infections caused by multiple Candida spp. were diagnosed almost every year. Of the 216 patients, 67 were children; and 55 infants needed intensive care. In 2005, C. glabrata caused an increase in the incidence of invasive fungal infections in the Neonatal Intensive Care Unit. The PFGE analysis of 12 isolates distinguished 4 different karyotypes. The incidence of bloodstream infections caused by fungi did not change during the 14-year study period. The most frequent species cultured from blood samples were C. albicans and C. glabrata. The incidence of resistant isolates remained constant. The local trends of fungaemia must be monitored and compared with global reports.

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Aetiology and antifungal susceptibility of yeast bloodstream infections in a Hungarian university hospital between 1996 and 2000

Cited by 34 publications

References 19 publications

Significance of yeasts in bloodstream infection: Epidemiology and predisposing factors of Candidaemia in adult patients at a university hospital (2010–2014)

Significance of yeasts in bloodstream infection: Epidemiology and predisposing factors of Candidaemia in adult patients at a university hospital (2010–2014)

Epidemiology, Species Distribution, Antifungal Susceptibility, and Outcome of Candidemia across Five Sites in Italy and Spain

Evaluation of fungaemia infections in a Hungarian university hospital between 1996 and 2009

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