Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo

Salinas, Franco Maximiliano; Vázquez, Luciana; Gentilini, M; ́Donohoe, Ailin O; Regueira, Eleonora; Jodar, Mercedes Soledad Nabaes; Viegas, Mariana; Michelini, Flavia; Hermida, Gladys N.; Alché, Laura E.; Bueno, Carlos Alberto

doi:10.1016/j.antiviral.2019.01.018

Cited by 34 publications

(48 citation statements)

References 32 publications

(43 reference statements)

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“…35 The typical symptoms of coronavirus disease 2019 (COVID-19) include pneumonia and inflammatory exudates. 37 Escin has immense potential in the therapy of severe pneumonia 23,38 ; it can reduce the levels of exudates on acute inflammation, which results in an effect similar to that of glucocorticoids (GCs). However, escin has no obvious inhibitory effect on the immune system, which is an advantage over GCs.…”

Section: Effect Of Escin On Acute Inflammationmentioning

confidence: 99%

Anti-Inflammatory and Gastroprotective Effects of Escin

Yang

Wang

Yuan

et al. 2020

Natural Product Communications

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Escin is a triterpenoid saponin extracted from the fruit of Aesculus wilsonii Rehd. and Aesculus hippocastanum (Hippocastanaceae). Clinically, it is widely used in the treatment of edema induced by either trauma or surgery, as well as treating chronic venous insufficiency. The anti-inflammatory and antiedema effects of escin have been extensively investigated. This article systematically reviews the effects of escin on inflammation and gastrointestinal diseases, including its role in inflammation, as an antioxidant, and in inhibiting gastric acid secretion and promoting gastrointestinal movement, especially, the molecular mechanism. The advantages and potential uses of escin have also been discussed.

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Section: Effect Of Escin On Acute Inflammationmentioning

confidence: 99%

Anti-Inflammatory and Gastroprotective Effects of Escin

Yang

Wang

Yuan

et al. 2020

Natural Product Communications

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“…The seeds of Aesculus turbinata Blume, a medicinal plant found in China, Japan, and South Korea, contain a natural saponins called escins, constituents with strong virucidal effects against SARS-CoV (EC 50 of 6 μM, selectivity index value of 2.5) (Kim et al 2017b ; Salinas et al 2019 ). Betulin and betulinic acid, the main antiviral components of the Betula L. plants, inhibit HIV fusion and one of the steps in HIV maturation (Chinsembu 2016a ).…”

Section: Discussionmentioning

confidence: 99%

Coronaviruses and Nature’s Pharmacy for the Relief of Coronavirus Disease 2019

Chinsembu

2020

Rev. Bras. Farmacogn.

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Current challenges to the treatment of coronavirus disease 2019 should open new prospects in the search for novel drugs from medicinal plants and other natural products. This paper provides details of natural agents that inhibit human coronavirus entry into cells, general replication, and specific chymotrypsin-like protease (3CL pro)-mediated replication. Medicinal plants, fungi, and marine organisms as remedies for human coronaviruses in China, Lebanon, Malaysia, Singapore, and South Africa are described. Common species include Alnus japonica (Thunb.

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“…RSV infection is the leading cause of acute respiratory tract infections in childhood. In RSV‐infected epithelial and macrophage cell lines, 5 µg/mL of escin and 25 µg/mL of Aesculus hippocastanum seed extract show significant virucidal and antiviral activities against RSV by modulating activities of NF‐κB, activator protein‐1, and cytokine 69 . In addition, herpes simplex virus‐1, vesicular stomatitis virus, and dengue virus are also inhibited by escin and seed extract in vitro.…”

Section: Anti‐inflammatory Antiviral Effects Of Escin In Vitro and Imentioning

confidence: 99%

Severe Acute Lung Injury Related to COVID‐19 Infection: A Review and the Possible Role for Escin

Gallelli

Zhang

Wang

et al. 2020

The Journal of Clinical Pharma

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Acute lung injury (ALI) represents the most severe form of the viral infection sustained by coronavirus disease 2019 (COVID‐19). Today, it is a pandemic infection, and even if several compounds are used as curative or supportive treatment, there is not a definitive treatment. In particular, antiviral treatment used for the treatment of several viral infections (eg, hepatitis C, HIV, Ebola, severe acute respiratory syndrome–coronavirus) are today used with a mild or moderate effect on the lung injury. In fact, ALI seems to be related to the inflammatory burst and release of proinflammatory mediators that induce intra‐alveolar fibrin accumulation that reduces the gas exchange. Therefore, an add‐on therapy with drugs able to reduce inflammation, edema, and cell activation has been proposed as well as a treatment with interferon, corticosteroids or monoclonal antibodies (eg, tocilizumab). In this article reviewing literature data related to the use of escin, an agent having potent anti‐inflammatory and anti‐viral effects in lung injury, we suggest that it could represent a therapeutic opportunity as add‐on therapy in ALI related to COVID‐19 infection.

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Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo

Abstract: Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo

Cited by 34 publications

References 32 publications

Anti-Inflammatory and Gastroprotective Effects of Escin

Anti-Inflammatory and Gastroprotective Effects of Escin

Coronaviruses and Nature’s Pharmacy for the Relief of Coronavirus Disease 2019

Severe Acute Lung Injury Related to COVID‐19 Infection: A Review and the Possible Role for Escin

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