Coronaviruses and Nature’s Pharmacy for the Relief of Coronavirus Disease 2019

Chinsembu, Kazhila C.

doi:10.1007/s43450-020-00104-7

Cited by 22 publications

(24 citation statements)

References 146 publications

(248 reference statements)

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“…Sulfated polysaccharides are a structurally multifaceted class of biomolecules with diverse physicochemical characteristics well recognized in the field of medicine and pharmaceutical sciences [ 29 ]. They have immunomodulatory properties and bioactivities [ 89 ].…”

Section: Pathogenesis Of Sars-cov-2mentioning

confidence: 99%

“…The TCM’s Jinchai consists of plant species such as Lonicera japonica and Bupleurum chinense among others, that prevent the coronavirus entry into cells and inhibit general viral replication as well as the specific 3CLpro-mediated replication [ 29 ]. One of the main active components of Jinchai is baicalin which inhibited antiviral activity with an Effective Concentration (EC 50 ) of 12-50 µg/mL in SARS-CoV-infected fetal rhesus monkey kidney cell line (fRHK4) and EC 50 of 100 µg/mL in Vero-E6 cells [ 93 ].…”

Section: Bioactive Compounds In the Mechanisms Of The Virus–host Interactionmentioning

confidence: 99%

“…The flavonoid hesperetin has the potential to inhibit ACE2 and block SARS-CoV-2 infection by binding to viralS protein, helicase, and protease sites of the ACE2 receptor [ 29 ].…”

Section: Bioactive Compounds In the Mechanisms Of The Virus–host Interactionmentioning

confidence: 99%

“…Among the virus-binding molecules, lectins have emerged as a new class of antivirals thanks to their ability to bind to the glycosylated molecules found on the surface of viruses such as the SARS-CoV spike glycoprotein [ 24 ]. One of the most potent molecules reported against SARS-CoV is the mannose-binding lectin isolated from leek ( Allium porrum L.), with an EC 50 of 0.45 μg/mL and a selectivity index >222 ( Table 2 and Table 3 ) [ 29 ]. Specific N-acetylglucosamine lectins obtained from tobacco ( Nicotiana tabacum L.) and stinging nettle ( Urtica dioica L.) were also active against SARS-CoV with selectivity indexes of >77 and >59, respectively [ 24 ].…”

Section: Bioactive Compounds In the Mechanisms Of The Virus–host Interactionmentioning

confidence: 99%

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Plants and Natural Products with Activity against Various Types of Coronaviruses: A Review with Focus on SARS-CoV-2

et al. 2021

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COVID-19 is a pandemic disease caused by the SARS-CoV-2 virus, which is potentially fatal for vulnerable individuals. Disease management represents a challenge for many countries, given the shortage of medicines and hospital resources. The objective of this work was to review the medicinal plants, foods and natural products showing scientific evidence for host protection against various types of coronaviruses, with a focus on SARS-CoV-2. Natural products that mitigate the symptoms caused by various coronaviruses are also presented. Particular attention was placed on natural products that stabilize the Renin–Angiotensin–Aldosterone System (RAAS), which has been associated with the entry of the SARS-CoV-2 into human cells.

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Section: Pathogenesis Of Sars-cov-2mentioning

confidence: 99%

Section: Bioactive Compounds In the Mechanisms Of The Virus–host Interactionmentioning

confidence: 99%

“…The flavonoid hesperetin has the potential to inhibit ACE2 and block SARS-CoV-2 infection by binding to viralS protein, helicase, and protease sites of the ACE2 receptor [ 29 ].…”

Section: Bioactive Compounds In the Mechanisms Of The Virus–host Interactionmentioning

confidence: 99%

Section: Bioactive Compounds In the Mechanisms Of The Virus–host Interactionmentioning

confidence: 99%

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Plants and Natural Products with Activity against Various Types of Coronaviruses: A Review with Focus on SARS-CoV-2

et al. 2021

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“…In addition, there is a search for pharmacological alternatives that can alleviate or prevent the ARDS problem. Among the elements that make up biodiversity, plant species are the raw material for the manufacture of numerous inputs, especially phytotherapics that have pharmacological attributes used in the treatment of coronavirus disease 2019 (Chinsembu 2020 ; Komolafe et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Anacardic Acid Monoene on the Respiratory System of Mice Submitted to Acute Respiratory Distress Syndrome

Gondim

Ferreira

Nogueira

et al. 2021

Rev. Bras. Farmacogn.

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Graphical abstract The acute respiratory distress syndrome caused by viral pathogens is a worldwide public health emergency. It is suggested that patients with this condition should be screened using therapies that address the need to prevent mortality. Anacardic acids found in Anacardium species have biological activities related to the antioxidant capacity of their double bonds in the lateral alkyl chain. The present study seeks to investigate the effects of anacardic acid monoene on acute respiratory distress syndrome caused by lipopolysaccharides. Experiments were carried out on mice divided into three groups: control group, acute respiratory distress-induced group, and anacardic acid monoene pretreated group, subsequently, induced to acute respiratory distress by lipopolysaccharides. Results showed that anacardic acid moeno was able to prevent changes in lung function and preserve its mechanical properties from containing inflammatory cell infiltrate, collapse of alveoli, and decreased airway resistance, suggesting that this compound may be effective in preventing the acute respiratory distress syndrome caused by viral pathogens. Supplementary Information The online version contains supplementary material available at 10.1007/s43450-021-00151-8.

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Combining network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of Astragali Radix

Guo

Sha

et al. 2022

Biomedical Chromatography

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Nowadays, cultivated variants and adulterants of Astragali Radix (AR) have flooded the market, causing the quality assurance of AR to be challenging. To address this issue, we combined network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of AR. Specifically, through network pharmacology, a complete understanding of the active components and pharmacological activities of AR was established. In addition, establishing fingerprint profiles and multicomponent quantitation by high-performance liquid chromatography (HPLC) is convenient and comprehensive, and can more fully reflect the overall situation of the distribution of various chemical components. To evaluate and differentiate AR from different origins, hierarchical cluster analysis and principal component analysis were performed. The result showed that AR acts synergistically through multiple targets and pathways. The content of chemical components in AR from different origins varied significantly. Combining network pharmacology and multicomponent quantification results, astragaloside II and IV and formononetin can be used as quality markers for the quality control of AR. This study provides a comprehensive and reliable strategy for the quality evaluation of AR and identifies its quality markers to ensure the quality of the herb.

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Coronaviruses and Nature’s Pharmacy for the Relief of Coronavirus Disease 2019

Cited by 22 publications

References 146 publications

Plants and Natural Products with Activity against Various Types of Coronaviruses: A Review with Focus on SARS-CoV-2

Plants and Natural Products with Activity against Various Types of Coronaviruses: A Review with Focus on SARS-CoV-2

Effects of Anacardic Acid Monoene on the Respiratory System of Mice Submitted to Acute Respiratory Distress Syndrome

Combining network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of Astragali Radix

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