Aerva lanata: A review on phytochemistry and pharmacological aspects

Goyal, Manoj; Pareek, Anil; Nagori, Badri Prakash; Sasmal, D.

doi:10.4103/0973-7847.91120

Cited by 52 publications

(30 citation statements)

References 13 publications

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“…Some herbs containing quercetin, kaempferol, and isorhamnetin, which are the main components in EGb, have been reported to have diuretic properties [24–26]. Herein, we investigated whether EGb had diuretic effect and explored the influence on CDDP excretion into the urine.…”

Section: Resultsmentioning

confidence: 99%

Protective Effect of Standardized Extract ofGinkgo bilobaagainst Cisplatin-Induced Nephrotoxicity

Song

Liú

Feng

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Cisplatin (CDDP) is a potent antitumor compound widely used with a notably side effect of nephrotoxicity inducing oxidative stress and apoptosis in kidneys. Standardized extract from the leaves of the Ginkgo biloba trees, labeled EGb761 (EGb), has been available on the market for its beneficial effects. The purpose of this study was to investigate the ability of EGb to prevent the nephrotoxic effect of CDDP and the mechanisms involved. Our results showed that EGb treatment restored the levels of creatinine, BUN, MDA, NO, SOD, CAT, GPx, and GSSG/GSH ratio in kidneys after CDDP injection. EGb also exhibited a tendency to decrease the elevated NF-κB translocation and caspase-3 protein levels in CDDP-treated kidneys. We further used a porcine kidney proximal tubular epithelial (LLC-PK1) cell line, finding that EGb accordingly inhibited ROS accumulation and iNOS increase induced by CDDP in vitro. EGb also attenuated IκB degradation and p65 NF-κB phosphorylation triggered by CDDP in LLC-PK1 cells. But EGb failed to influence CDDP-stimulated caspase cascade. These findings suggested that EGb's renoprotective effect might be mediated by not only its well-known antioxidant activity but also the anti-inflammatory activity.

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Section: Resultsmentioning

confidence: 99%

Protective Effect of Standardized Extract ofGinkgo bilobaagainst Cisplatin-Induced Nephrotoxicity

Song

Liú

Feng

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…(Apocynaceae) extracts led instead to the discovery and isolation of complex indole alkaloids vinblastine and vincristine (Noble, 1990). The roots of AL are also reported to possess antidiabetic activity and contain major indole cathin-6-one alkaloid (Appia et al, 2009;Deshmukh et al, 2008;Goyal et al, 2011;Rajesh et al, 2011;Saravana et al, 2011). Our study confirms the previous Figure 6.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic activity of alkaloids ofAerva lanataroots on streptozotocin-nicotinamide induced type-II diabetes in rats

Agrawal¹,

Sethiya²,

Mishra³

2013

Pharmaceutical Biology

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Context: The roots of Aerva lanata Linn. (Amaranthaceae) (AL) are employed traditionally as an antihyperglycaemic in the Ayurvedic system of medicine. Objective: The present investigation is focus for identification and isolation of the bioactive compound from methanol roots extract of AL against streptozocin-nicotinamide induced elevated serum glucose level in rats. Materials and methods: The methanol extract of the roots was fractionated using different solvents. The partially purified alkaloid basified toluene fraction (PPABTF) showed the presence of alkaloids. The fraction (10 and 20 mg/kg) was tested for oral glucose tolerance test (OGTT) and in non-insulin-dependent diabetes mellitus (NIDDM)-induced elevated serum glucose level in rats. The fraction was also subjected to high performance thin layer chromatography (HPTLC) for the determination of content of individual alkaloids. Results: Single oral administration of PPABTF (10 and 20 mg/kg) after 20 h caused a significant (p50.01) reduction in the serum glucose level (mg/dl). On other hand, PPABTF normalised plasma glucose levels after 2 weeks of repeated oral administration in diabetic rats (p50.01). HPTLC analysis on PPABTF showed the presence of three known alkaloids. The fraction was further subjected to column chromatography and the compounds identified by ultraviolet, infrared, mass spectroscopy and nuclear magnetic resonance, as canthin-6-one derivatives. Conclusion and discussion: The PPABTF in the dose of 20 mg/kg showed significant effects on streptozotocin-nicotinamide induced type-II NIDDM in rats. The activity may be due to the presence of alkaloids like canthin-6-one derivatives.

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“…Significant time taken for the synthesis and availability of an approved allopathic drug in the market should be considered as a cause for serious concern in health care settings. Research is rigorously on for finding alternatives to allopathic antimicrobial agents, which include preparation of synthetic antibiotics, evaluating the nanoparticles for their utility in treating infections and analysing the activities of various plant extracts for their medicinal properties [3,4,5].…”

Section: Introductionmentioning

confidence: 99%

Identification of Newer Antimicrobial Agents: A Study of Invitro Antibacterial and Antifungal Activities of Leaf extracts of Medicinal Plant <i>Aerva lanata</i> (L.) Juss. ex Schult

Kairamkonda¹,

Godishala²,

Kandi³

2017

AJMR

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In the era of presence and spread of infectious diseases caused by microorganisms demonstrating resistance against most antimicrobial agents routinely used in the treatment, there is a serious need of search for potential agents which can be used as antimicrobials. The plant extracts of Aerva lanata were collected and processed using standard procedures. Whatman filter papers were then impregnated with varied concentrations of plant extract and antimicrobial susceptibility testing was performed using Kirby-Bauer disk diffusion method for bacteria. The standard disk diffusion method was used to test antifungal drugs against yeasts, and non-dermatophyte filamentous fungal isolates.The ethanolic extract at a concentration of 600 µg/ mL and 900 µg/ mL showed increased antibacterial activities against Esherichia coli as compared to the standard drug tested at similar concentrations. The chloroform extracts and the ethanol extract revealed increased antibacterial activity against Klebsiella pneumoniae. The chloroform solvent extract showed similar antifungal activities as the standard drug against Candida albicans, and the H 2 O extract showed greater antifungal activity against Drechslera halodes as compared to the control drug tested. Antibacterial and antifungal properties of leaf extracts of Aerva lanata plant in comparison with the control drugs revealed either similar or increased activities signifying their potential for future candidates as antimicrobial agents.

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Aerva lanata: A review on phytochemistry and pharmacological aspects

Cited by 52 publications

References 13 publications

Protective Effect of Standardized Extract ofGinkgo bilobaagainst Cisplatin-Induced Nephrotoxicity

Protective Effect of Standardized Extract ofGinkgo bilobaagainst Cisplatin-Induced Nephrotoxicity

Antidiabetic activity of alkaloids ofAerva lanataroots on streptozotocin-nicotinamide induced type-II diabetes in rats

Identification of Newer Antimicrobial Agents: A Study of Invitro Antibacterial and Antifungal Activities of Leaf extracts of Medicinal Plant <i>Aerva lanata</i> (L.) Juss. ex Schult

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