Aerosolized Vancomycin for Treatment of Airway Colonization by Methicillin-Resistant Staphylococcus Aureus

Weathers, Laura; Riggs, Dan; Santeiro, Maria L.; Weibley, Richard E.

doi:10.1097/00006454-199003000-00017

Cited by 30 publications

(14 citation statements)

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“…Despite reports of local pain and soft tissue necrosis due to paravasal injection, different in vivo studies have reported the effectiveness of a local antibiotic therapy using vancomycin, stating a low antigenicity and rare toxic side effects [24][25][26]. Accordingly, experiments performed to investigate the cytotoxicity of vancomycin in cultured human fibroblasts and keratinocytes revealed a high level of tissue tolerance [27].…”

Section: Discussionmentioning

confidence: 99%

Release of Vancomycin and Teicoplanin from a Plasticized and Resorbable Gelatin Sponge: in Vitro Investigation of a New Antibiotic Delivery System with Glycopeptides

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Release of Vancomycin and Teicoplanin from a Plasticized and Resorbable Gelatin Sponge: in Vitro Investigation of a New Antibiotic Delivery System with Glycopeptides

et al. 2006

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“…However, the only available data include a case report of successful treatment for chronic MRSA infection in a 10-year-old CF patient [41] and eradication of MRSA colonization in children with bronchopulmonary dysplasia [42] and in elderly patients [43].…”

Section: Ventilator-associated Pneumoniamentioning

confidence: 99%

Inhaled antimicrobial therapies for respiratory infections

Kim¹,

Kuti²,

Nicolau

2008

Curr Infect Dis Rep

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Inhaled antimicrobial therapy is attractive because of its potential to provide high concentrations of antimicrobials to the site of active respiratory infections while avoiding systemic toxicity. Many antimicrobials have been used in inhaled preparations, including aminoglycosides, colistin sodium, cephalosporins, penicillins, vancomycin, amphotericin B, and several antiviral compounds. This review highlights available data on inhaled antimicrobials, antifungals, and antivirals for the prevention and treatment of infections of the respiratory tract.

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“…Inhalation vancomycin is perhaps the best studied of these agents. Case reports and small, nonrandomized, prospective studies have suggested that aerosolized vancomycin can eliminate upper respiratory tract MRSA colonization [22]. The US Centers for Disease Control and Prevention has discouraged the use of vancomycin for this purpose, primarily due to concerns that inadvertently ingested drug could result in the selection of vancomycin-resistant enterococci [37].…”

Section: Nebulized Antibioticsmentioning

confidence: 99%

Nasal colonization with methicillin-resistant Staphylococcus aureus: Clinical implications and treatment

Friedel¹,

Climo²

2007

Curr Infect Dis Rep

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Methicillin-resistant Staphylococcus aureus (MRSA) has become an increasingly important pathogen during the past 30 years, and infections due to MRSA are associated with substantial morbidity and mortality. Despite intensive infection control measures, the prevalence of MRSA has increased significantly, and the organism has become endemic in many hospitals worldwide. Asymptomatic nasal carriage of MRSA has been identified as a major risk factor for subsequent S. aureus infection in multiple settings and populations. As a result, considerable interest exists in developing decolonization strategies, with the ultimate goal of reducing the incidence of MRSA infection. Approaches to decolonization have included the use of systemic and inhalation anti-biotics, antiseptic washes, and topical antimicrobials.

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Aerosolized Vancomycin for Treatment of Airway Colonization by Methicillin-Resistant Staphylococcus Aureus

Cited by 30 publications

References 0 publications

Release of Vancomycin and Teicoplanin from a Plasticized and Resorbable Gelatin Sponge: in Vitro Investigation of a New Antibiotic Delivery System with Glycopeptides

Release of Vancomycin and Teicoplanin from a Plasticized and Resorbable Gelatin Sponge: in Vitro Investigation of a New Antibiotic Delivery System with Glycopeptides

Inhaled antimicrobial therapies for respiratory infections

Nasal colonization with methicillin-resistant Staphylococcus aureus: Clinical implications and treatment

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