Aerosolized albuterol improves airway reactivity in infants with acute respiratory failure from respiratory syncytial virus

Derish, Melinda T.; Hodge, Glenn; Dunn, Colleen; Ariagno, Ronald L.

doi:10.1002/(sici)1099-0496(199807)26:1<12::aid-ppul4>3.0.co;2-k

Cited by 20 publications

(14 citation statements)

References 38 publications

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“…Although one small study showed improvement in all five patients (29), one showed improvement in 7 of 14 (30), one showed no benefit in 50% of the subjects, a small benefit in 45% and deterioration in 5% (31). The other study showed improvement in 3 of 25 to normal range of measured pulmonary function and deterioration in 3 of 25 (32).…”

Section: Discussionmentioning

confidence: 88%

A prospective randomized controlled blinded study of three bronchodilators in infants with respiratory syncytial virus bronchiolitis on mechanical ventilation*

Levin

Garg

Hall

et al. 2008

Pediatric Critical Care Medicine

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Similar statistically significant bronchodilation occurred after all three bronchodilators as indicated by a decrease in peak inspiratory pressure and respiratory system resistance, but these changes were small and probably clinically insignificant. However, side effects of bronchodilators, such as tachycardia, also occurred, and these may be clinically significant. Thus the benefit of bronchodilator treatment in these patients is small, does not differ among the drugs we studied and of questionable value.

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Section: Discussionmentioning

confidence: 88%

A prospective randomized controlled blinded study of three bronchodilators in infants with respiratory syncytial virus bronchiolitis on mechanical ventilation*

Levin

Garg

Hall

et al. 2008

Pediatric Critical Care Medicine

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“…Epidemiologic data has revealed that in infants with bronchiolitis, the prevalent pathogen is RSV and that it is strongly associated with wheezing. Currently, treatment with ribavirin and aerosolized albuterol are effective treatment strategies for acute RSV illnesses in children with asthma [22]. Preventive agents may be beneficial to this population also, in that RSV bronchiolitis or pneumonia in infancy is thought to contribute to the development of asthma in vulnerable individuals, but this is not clear.…”

Section: Pastmentioning

confidence: 99%

Respiratory Syncytial Virus (RSV) Prevention and Treatment: Past, Present, and Future

Weisman¹

2009

CHAMC

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Respiratory syncytial virus (RSV) is a very important pathogen worldwide. It occurs and recurs naturally throughout life. Both short and long term morbidity, and mortality are particularly significant for infants, especially those infants with underlying conditions and risk factors. Current treatment strategies for these patients (e.g Ribavirin) are limited but several new interventions (e.g. RSV604, BTA9881, ALN-RSV01) are under investigation. Several preventive agents and strategies have been developed (e.g. RSV-IGIV, palivizumab) and others are in the pipeline (e.g. motavizumab) and under development (e,g, Medi-557). In this article, we review the RSV clinical condition with a focus on the highest risk populations. In addition we review prevention and treatment strategies of the past, present and future for these high-risk patients. This review should provide a single valuable source of information to clinicians and investigators.

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“…A terapêutica com broncodilatadores é mais efetiva no estágio inicial da infecção, momento em que as pequenas vias aéreas não estão obstruídas com secreções e debris celulares 25,26 .…”

Section: Beta-2 Agonistasunclassified

Bronquiolite aguda, uma revisão atualizada

Carvalho¹,

Johnston²,

Fonseca³

2007

Rev. Assoc. Med. Bras.

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A BA é a síndrome do sistema ventilatório (SV) mais freqüente e grave que acomete a criança jovem nos dois primeiros anos de vida (sendo encontrada em crianças até 2-3 anos de idade) e o pico de incidência ocorre abaixo dos 12 meses de idade. Tem um padrão epidêmico com prevalência no outono e inverno. Durante o período de inverno, é a causa mais freqüente de hospitalização de lactentes 1 . Inicia-se com os sintomas das infecções virais do SV superior (febre e coriza), que progridem em quatro a seis dias, evoluindo para o acometimento do SV inferior (tosse e chiado).Em geral, é uma doença autolimitada, com uma taxa de mortalidade baixa (<1%), embora possa ser mais elevada (30%) em grupos de crianças de alto risco (prematuros, com displasia broncopulmonar, cardiopatia congênita e imunocomprometidos, desnutridos, entre outros), em que está associada a doença prolongada e maior risco de óbito.Crianças com idade inferior a seis meses apresentam risco de doença grave decorrente da BA. A doença é sazonal e coincide com as epidemias de infecções secundárias a patógenos respiratórios virais 2 . Ocasiona a inflamação e a obstrução dos bronquíolos. O agente etiológico mais freqüente é o VSR, mas a BA também pode ser ocasionada pelo parainfluenza, adenovírus, influenza, Mycoplasma pneumoniae, rinovírus, Chlamydia pneumoniae, metapneumovírus humano e coronavírus. PATÓGENOSV S R O VSR pode ser dividido em dois grandes grupos: A (cepa dominante) e B. Este vírus cresce de maneira ótima no pH de 7,5 e, embora seja sensível à temperatura, é recuperado após mais de uma hora em luvas contaminadas com secreção nasal infectada pelo vírus. Esta estabilidade no ambiente hospitalar contribui para colocá-lo como um patógeno nosocomial. -taquipnéia (FR>60-80irpm ou retrações) -hipóxia (SaO 2 <90%) -dificuldade de se alimentar ou desidratação -idade <12 meses (quanto menor a idade maior o risco) -displasia broncopulmonar -cardiopatia congênita -fibrose cística -imunodeficiência -idade gestacional <36 semanas -desnutrição-baixo poder aquisitivo -aglomeração -pais e/ou familiares fumantes -predisposição genética para infecções por VSR

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Aerosolized albuterol improves airway reactivity in infants with acute respiratory failure from respiratory syncytial virus

Cited by 20 publications

References 38 publications

A prospective randomized controlled blinded study of three bronchodilators in infants with respiratory syncytial virus bronchiolitis on mechanical ventilation*

A prospective randomized controlled blinded study of three bronchodilators in infants with respiratory syncytial virus bronchiolitis on mechanical ventilation*

Respiratory Syncytial Virus (RSV) Prevention and Treatment: Past, Present, and Future

Bronquiolite aguda, uma revisão atualizada

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