Aerosol transport in a model of human lungs

Lízal, František; Jedelský, Jan; Lippay, Josef; Halasová, Tereza; Mravec, Filip; Jícha, Miroslav

doi:10.1051/epjconf/20122501050

Cited by 1 publication

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References 13 publications

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“…Thus DEHS was used in condensation monodisperse aerosol generator with sodium chloride nuclei and deposition in a model of human lungs was evaluated. It was found out that the fluorescence of DEHS can be measured, but it is not directly proportional to the amount of deposited aerosol [5]. Therefore fluorescence dye, fluorescein sodium salt, was tested.…”

Section: 2mentioning

confidence: 99%

Comparison of methods for evaluation of aerosol deposition in the model of human lungs

Bělka

Lippay²,

Lízal

et al. 2014

EPJ Web of Conferences

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Abstract. It seems to be very convenient to receive a medicine by inhalation instead of injection. Unfortunately transport of particles and targeted delivery of a drug in human respiratory airways is very complicated task. Therefore we carried out experiments and tested different methods for evaluation of particle deposition in a model of human lungs. The model included respiratory airways from oral cavity to 7th generation of branching. Particles were dispersed by TSI Small-scale Powder Disperser 3433 and delivered to the model. The model was disassembled into segments after the deposition of the particles and local deposition was measured. Two methods were used to analyse the samples, fluorescence spectroscopy and optical microscopy. The first method was based on measuring the intensity of luminescence, which represented the particle deposition. The second method used the optical microscope with phase-contrast objective. A dispersion of isopropanol and particles was filtrated using a vacuum filtration unit, a filter was placed on glass slide and made transparent. The particles on the filter were counted manually and the deposition was calculated afterwards. The results of the methods were compared and both methods proved to be useful.

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Section: 2mentioning

confidence: 99%