Aerosol recovery from large-volume reservoir delivery systems is highly dependent on the static properties of the reservoir

Abstract

Aerosol recovery from large-volume reservoir delivery systems is highly dependent on the static properties of the reservoir. M.J. van der Veen, J.S. van der Zee. #ERS Journals Ltd 1999. ABSTRACT: In this study, the role of electrostatic fields on aerosol recovery from a system with a large collapsible reservoir (30 L) was investigated. In addition, the efficacy of the reservoir method for bronchial challenge procedures was assessed in vivo.Aerosol recovery was determined by measuring the fraction of aerosol (0.05% 99m Tc-tagged human albumin solution) retrieved from the reservoir. Before aerosol recovery experiments, electrostatic fields in the reservoir were measured.Aerosol recovery varied significantly with wall thickness of the reservoir and presence of an antistatic coating (range 6.0±70.3%). A close inverse relationship was found between the mean electrostatic field in the reservoir and aerosol recovery. The nebulized provocative concentration of histamine causing a 20% fall in forced expiratory volume in one second in asthmatics was found to be approximately half that of a standard method when compared with the reservoir system (mean ratio 2.24 (95% confidence interval, 1.60±3.12)).Recovery from an aerosol delivery system with a relatively large collapsible aerosol reservoir was highly dependent on the electrostatic field in the reservoir. In these systems the use of electrostatic field dissipative material for the reservoir is therefore recommended. Eur Respir J 1999; 13: 668±672.

Allergen‐induced bronchial inflammation in house dust mite‐allergic patients with or without asthma

“…Bronchial allergen challenge was performed by using a reservoir aerosol delivery system as described previously [15, 16]. Briefly, a collapsible reservoir of approximately 30 L, made of static field dissipative material (RCAS 1206, Richmond, Redlands, CA, USA) and filled with dry air, was connected to a highly efficient jet nebulizer (Mallinckrodt Diagnostica, Petten, the Netherlands) producing an allergen aerosol from 0.5 mL allergen solution.…”

Salmeterol enhances pulmonary fibrinolysis in healthy volunteers

“…The subjects inhaled either placebo (vehicle) or salmeterol (4 ϫ 25 g [100 g total]; GlaxoSmithKline, Zeist, the Netherlands) using a metered-dose inhaler attached to a Volumatic (750 mL; GlaxoSmithKline); 30 mins later, they inhaled either normal saline or LPS (from Escherichia coli O26: B6, 100 g dissolved in normal saline; SigmaAldrich, St. Louis, MO) using a large-volume reservoir delivery system as described previously (31,32). Hence, four groups of eight subjects were studied: placebo/saline, salmeterol/saline, placebo/LPS, and salmeterol/LPS.…”

Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxin

“…The study was approved by the Institutional Ethics and Research Committees, Academic Medical Center, University of Amsterdam, and written informed consent was obtained from all subjects before enrolment in the study. The subjects inhaled normal saline (n58) or LPS (n58; from Escherichia coli O26:B6, 100 mg; Sigma-Aldrich, St Louis, MO, USA) using a largevolume reservoir delivery system as previously described [8,9]. LPS was purified by phenol extraction and had a protein content ,3%; this specific LPS preparation has been used by the authors' and other laboratories in earlier studies with human volunteers [10][11][12][13].…”