“…Incorporation of nebulizers into HFNC delivery systems has gained interest in recent years [2,3,4,5,6,7,8], for its combined benefits of comfort associated with nasal interface, trans-nasal pulmonary delivery of aerosolized medication, and mechanical benefits of HFNC. Aerosol with HFNC has been described with bronchodilators for asthmatic [2], bronchiolitis [3,4], or chronic obstructive pulmonary disease (COPD) patients [5,6,7], and inhaled epoprostenol for patients with pulmonary hypertension or hypoxemia [8]. Interruption of HFNC for administration of standard aerosol treatment for periods up to 15 min may compromise oxygenation, and administration by mouth, while receiving HFNC reduces the inhaled dose.…”