Aerococcus urinae: a possible reason for malodorous urine in otherwise healthy children

Lenherr, Nina; Berndt, Anita; Ritz, Nicole; Rudin, Christoph

doi:10.1007/s00431-014-2348-9

Cited by 14 publications

(6 citation statements)

References 9 publications

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“…In most of the reports, urine findings are similar to ours, where numerous bacteria were present as well as high levels of leukocytes (9,12). In the case of the asymptomatic pediatric patient where high levels of leukocytes in urine were not found, authors suggested that isolation of A. urinae could be a consequence of child's bad hygiene, certain food intake, undesired loss of urine/feces or a consequence of underlying metabolic disease (11).…”

Section: Discussionsupporting

confidence: 76%

“…Regarding the current urine findings and A. urinae isolation, there could be a possible link between his earlier condition and local treatment with corticosteroid cream. In other pediatric patients as predisposing factors were suggested bladder diverticulum (9), pelvic juxtaglomerular obstruction and kidney reflux (7), while in some cases no predisposing factors were found (10,11).…”

Section: Discussionmentioning

confidence: 97%

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What Is fishy in asymptomatic patients?: Co-occurrence of Aerococcus urinae infection in pediatric patient with phimosis

Smieško¹,

Banović²,

Gusman³

et al. 2021

Acta fac medic Naissensis

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Here we present the first case of Aerococcus urinae isolated from urine sample of a 5-year-old boy from Vojvodina province (Serbia). The patient had predisposing factors related to the susceptibility of genitourinary system to infection. Thus, he reported no complaints related to active urinary infections. Eradication of infection was achieved after 10-day treatment with meropenem. From this case, the question emerges: Is there a possibility that A. urinae infections are neglected in pediatric patients with susceptibility of genitourinary system to infection? Only after wide introduction of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in competent laboratories, we will be able to give a precise answer.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 97%

What Is fishy in asymptomatic patients?: Co-occurrence of Aerococcus urinae infection in pediatric patient with phimosis

Smieško¹,

Banović²,

Gusman³

et al. 2021

Acta fac medic Naissensis

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“…Furthermore, conditioned pathogens including Facklamia , Aerococcus , Staphylococcus , and Corynebacterium were enriched in rats in DMG and modified after the oral administration of HLJDD, indicating that the relative abundance of these bacteria might be associated with the pathological status of T2DM ( Koch et al, 2014 ; Wolcott et al, 2016 ; Rahmati et al, 2017 ). The conditioned pathogens mentioned above, which were positively correlated with inflammation in body, might be the targeted bacteria involved the progress that HLJDD alleviated T2DM ( Lenherr et al, 2014 ). At the same time, Allobaculum , Lachnobacterium , and Coprococcus , which enriched in DMG compared to NCG, were reversed by HLJDD treatment.…”

Section: Discussionmentioning

confidence: 99%

Huang-Lian-Jie-Du-Decoction Ameliorates Hyperglycemia and Insulin Resistant in Association With Gut Microbiota Modulation

Chen

Liao

et al. 2018

Front. Microbiol.

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Background: Huang-Lian-Jie-Du-Decoction (HLJDD), a prescription of traditional Chinese medicine, has been clinically used to treat diabetes for thousands of years and its mechanism was reported to be related to gut microbiota. However, no study has explored the effect of HLJDD on the gut microbiota in type 2 diabetes mellitus (T2DM) yet. Therefore, in this study, we investigated the modulation of gut microbiota induced by HLJDD treatment in T2DM in order to unveil the underlying mechanism.Methods: A combination of high-fat diet (HFD) and streptozotocin (STZ) was used to induce T2DM in rats. Bacterial communities in the fecal samples from the control group, the T2DM model group, and the HLJDD-treated T2DM group were analyzed by 16S gene sequencing, followed with a subset sample analyzed by shotgun sequencing.Results: The HLJDD treatment significantly ameliorated hyperglycemia and inflammation in T2DM rats. Additionally, our results indicated that HLJDD treatment could not only restore the gut dysbiosis in T2DM rats, which was proved by an increasing amount of short chain fatty acids (SCFAs)-producing and anti-inflammatory bacteria such as Parabacteroides, Blautia, and Akkermansia as well as a decreasing amount of conditioned pathogenic bacteria (e.g., Aerococcus, Staphylococcus, and Corynebacterium), but also modulate the dysregulated function of gut microbiome in T2DM rats, including an up-regulation in bile acid biosynthesis as well as a reduction in glycolysis/gluconeogenesis and nucleotide metabolism.Conclusion: HLJDD treatment could ameliorate hyperglycemia and restore the dysregulated microbiota structure and function to a normal condition mainly by increasing SCFAs-producing bacteria and reducing conditioned pathogenic bacteria in T2DM rats, which provides insights into the mechanism of HLJDD treatment for T2DM from the view of gut microbiota.

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“…It has been suggested, that A. urinae is a rare cause of extraordinary malodorous urine in otherwise healthy boys [ 5 , 6 ]. This is in contrast to the fact that generally, parental reporting of “smelly urine” is not indicative of a UTI [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…This is in contrast to the fact that generally, parental reporting of “smelly urine” is not indicative of a UTI [ 7 ]. In the case of A. urinae , the presence of additional pathogens in urine culture is reported potentially enhancing the extraordinary odour [ 6 ]. However, monoculture has been more frequently reported in case reports when A. urinae is detected with malodorous urine [ 5 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Aerococcus urinae — significance of detection in the paediatric urinary tract: a case series

et al. 2022

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Aerococcus urinae (A. urinae) is primarily recognized as a common pathogen in the geriatric population, causing urinary tract infection (UTI), sepsis, and endocarditis, predominantly in female patients. In the paediatric population, only a few case reports exist suggesting A. urinae causes malodorous urine in otherwise healthy boys. In this study, we investigated the spectrum of clinical and laboratory presentations of A. urinae detection in children. A retrospective, single-centre, case series including all patients with the detection of A. urinae during a 7-year study period. Patients with detection of A. urinae only in non-urogenital skin swabs were excluded. A total of 40 samples from 33 patients were identified of which 20 patients were included in the final analysis. The median (IQR) age was 6.8 (2.9–9.5) years; 18 (90%) patients were boys. Four patients were diagnosed with a UTI, six had malodorous urine without UTI, three were diagnosed with balanitis and seven showed A. urinae colonization in the urine culture. Urogenital disorders were present in 12 patients. Additional pathogens were detected in 13 patients. Recurrence of detection during our study period was observed in four (20%) patients. Conclusion: Beyond malodorous urine, A. urinae detection is associated with more severe presentations including UTI in the paediatric population. Pre-existing urogenital disorders were frequent, and therefore, a nephro-urological investigation should be considered in all cases of A. urinae detection in the paediatric population. What is Known:• Aerococcus urinae (A. urinae) is known to be a common pathogen in the geriatric population, causing urinary tract infection (UTI), sepsis, and endocarditis, predominantly in female patients.• In the paediatric population, A. urinae is mainly described as a low-grade pathogen. Some case reports describe A. urinae as the cause of extraordinary malodorous urine in otherwise healthy boys. What is New:• Beyond malodorous urine, A. urinae detection is associated with more severe presentations including UTI in the paediatric population.• A. urinae was mainly detected in boys with pre-existing urogenital disorders; therefore, a nephro-urological investigation should be considered in cases of A. urinae detection in the paediatric population.

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Aerococcus urinae: a possible reason for malodorous urine in otherwise healthy children

Abstract: As treatment of A. urinae infection is simple, we recommend that in healthy children with malodorous urine, this pathogen is excluded before the initiation of costly metabolic investigations.

Cited by 14 publications

References 9 publications

What Is fishy in asymptomatic patients?: Co-occurrence of Aerococcus urinae infection in pediatric patient with phimosis

What Is fishy in asymptomatic patients?: Co-occurrence of Aerococcus urinae infection in pediatric patient with phimosis

Huang-Lian-Jie-Du-Decoction Ameliorates Hyperglycemia and Insulin Resistant in Association With Gut Microbiota Modulation

Aerococcus urinae — significance of detection in the paediatric urinary tract: a case series

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