Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men

Glisezinski, Isabelle de; Moro, Cédric; Pillard, Fabien; Marion-Latard, F.; Harant, I.; Meste, M.; Berlan, Michel; Crampes, F.; Rivière, D.

doi:10.1152/ajpendo.00152.2003

Cited by 45 publications

(31 citation statements)

References 34 publications

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“…In vitro studies using isolated human adipocytes show that ␤-adrenergic stimulation of lipolysis is attenuated by activation of ␣ 2 -ARs by epinephrine and norepinephrine (2,33,34,53). Catecholamines regulate lipolysis in adipose tissue by interacting with both the ␣-ARs and ␤-ARs (2,4,10,16,47). Interestingly, it appears that the antilipolytic ␣-ARs predominate in SCAAT, as opposed to femoral and gluteal adipocytes, and that epinephrine has a higher affinity for ␣-ARs than ␤-ARs (5).…”

mentioning

confidence: 99%

Regulation of fat metabolism during resistance exercise in sedentary lean and obese men

Ormsbee

Choi²,

Medlin³

et al. 2009

Journal of Applied Physiology

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The effect of acute resistance exercise (RE) on whole body energy expenditure (EE) and alpha(2)-adrenergic receptor (alpha(2)-AR) regulation of lipolysis in subcutaneous abdominal adipose tissue (SCAAT) was determined in sedentary lean (LN) and obese (OB) men. Lipolysis was monitored using microdialysis in 10 LN [body mass index (BMI) 20.9 +/- 0.6] and 10 OB (BMI 36.2 +/- 2.7) men before, during, and for 24 h after RE. EE was measured before and immediately after RE for 40 min. Changes in interstitial glycerol were measured in SCAAT with three microdialysis probes perfused with a control solution, phentolamine (alpha(2)-AR antagonist), or propranolol (beta-AR antagonist). EE and fat oxidation (FOX) were significantly (P < 0.001) elevated immediately post-RE compared with pre-RE in LN and OB subjects, with no differences between groups. RE-induced increases in SCAAT glycerol concentrations from rest to peak exercise were greater in LN than in OB men in the control (LN 142.1 +/- 30.8 vs. OB 65.4 +/- 14.2%, P = 0.03) and phentolamine probes (LN 187.2 +/- 29.6 vs. OB 66.7 +/- 11.0%, P = 0.002). Perfusion of propranolol had no effect on interstitial glycerol concentrations over the time course of the experiment in either group. Plasma insulin concentrations were significantly lower (P = 0.002) and plasma growth hormone (GH) was significantly higher (P = 0.03) in LN compared with OB men. The mechanism behind RE contributing to improved body composition may in part be due to enhanced SCAAT lipolysis and improved EE and FOX in response to RE in LN and OB men. The blunted SCAAT lipolytic response to RE in OB compared with LN men is unrelated to RE-induced catecholamine activation of the antilipolytic alpha(2)-ARs and may be due to depressed GH in OB subjects.

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confidence: 99%

Regulation of fat metabolism during resistance exercise in sedentary lean and obese men

Ormsbee

Choi²,

Medlin³

et al. 2009

Journal of Applied Physiology

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“…The latter is composed of abdominal subcutaneous and visceral fat depots. Lipolysis in abdominal subcutaneous adipose tissue was shown to increase during 31 and after 32 an exercise of high intensity. In addition, visceral adipocytes have a higher responsiveness to the lipolytic effect of catecholamines than subcutaneous adipocytes.…”

Section: Discussionmentioning

confidence: 99%

Behavioral and physiological regulation of body fatness: a cross-sectional study in elderly men

Rimbert¹,

Montaurier²,

Boccadoro³

et al. 2005

Int J Obes

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Objective: To identify the characteristics of physical activity that are the most correlated to total and truncal fatness and to physiological parameters involved in fat oxidation in elderly men. Design: Cross-sectional study. Subjects: A total of 25 healthy elderly men selected with a wide range of physical activity behavior (65.973.4 years). Measurements: Total and truncal fat masses (by dual-energy X-ray absorptiometry), time spent and energy expended (EE day ) at specific activity intensities (o40, 40-60, 460% VO 2max ) during 1 week in free living conditions (using heart rate recording and individual calibrated equations), sport-exercising volume (V sport , using Baecke questionnaire), maximal oxygen uptake (VO 2max ), muscle fat oxidative capacity (OX FA , using muscle biopsy), lipid oxidation and respiratory exchange ratio during exercise at 50% VO 2max (using indirect calorimetry). Results: V sport was the main determinant of total and truncal fatness, VO 2max and OX FA (r ¼ À0.69, Po0.0001; r ¼ À0.80, Po0.0001; r ¼ 0.70, Po0.0001; r ¼ 0.66, Po0.001, respectively). Among physical activity parameters measured over a week, total EE day was the main determinant of total fat mass. Furthermore, EE day at % VO 2max 460 was closely correlated to truncal fat mass, VO 2max and OX FA (r ¼ À0.58, P40.01; r ¼ 0.55, Po0.01; r ¼ 0.49, Po0.05, respectively). Finally, VO 2max and OX FA were positively correlated to absolute fat oxidation and to the contribution of fat to energy production during moderate exercise. Conclusion: Sport-exercising volume is the main factor regulating total and truncal fat masses and physiological parameters involved in fat oxidation. With regard to the characteristics of physical activity, overall energy expended during the alert period plays a major role in the regulation of total body fatness. In addition, vigorous exercises may be beneficial for the regulation of abdominal fat depot partly through the stimulation of muscle fat oxidation during the effort.

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“…The reduction in this last process among overweight subjects could be secondary to a greater sedentary lifestyle compared with subjects of normal weight. This assertion is based on results from a previous study indicating that aerobic training (4‐month training program consisting of aerobic exercise 5 d/wk) can improve exercise‐induced lipolysis and lipid use in overweight men (26). Nevertheless, a causal relationship cannot be proposed to interpret our results.…”

Section: Discussionmentioning

confidence: 99%

Lipid Oxidation According to Intensity and Exercise Duration in Overweight Men and Women

Pillard

Moro

Harant

et al. 2007

Obesity

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Research Methods and Procedures: Nine young, healthy, overweight men and women were studied (age, 31.4 Ϯ 2.3 and 26.7 Ϯ 2.1 years; BMI, 27.9 Ϯ 0.4 and 27.2 Ϯ 0.5; for men and women, respectively). On one study day, the subjects first performed 30 minutes of cycling exercise at 30% of their maximal oxygen uptake (VO 2max ; E1 session), followed by 30 minutes of exercise at 50% VO 2max (E2 session). On a second study day, a similar E1 session was followed by 30 minutes of exercise at 70% VO 2max (E3 session). From the gas exchange measurements, the respiratory exchange ratio (RER) and the fat oxidation rate (FOR) were calculated. Plasma concentrations of glycerol and non-esterified fatty acids (NEFAs) were assayed. Results: RER was significantly lower for women during only the E1 session. For both sexes, RER decreased over time during the E2 and E3 sessions. During the E1 session, the FOR per kilogram of lean mass (LM) was higher among women, and it did not change over time despite an increase in plasma NEFAs. FOR per kilogram of LM was higher during the E2 exercise for both sexes. During E2 and E3 sessions, as the exercise time was prolonged, the FOR/kg LM increased simultaneously with the increase in the plasma glycerol. Discussion: Lipid oxidation during exercise is optimized for moderate and lengthy exercise. The enhancement of lipid oxidation occurring over time during moderate-and high-intensity exercises could be, in part, linked to the improvement of lipid mobilization. This fact is discussed to shed light on exercise modalities as a tool for the management of overweight.

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Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men

Cited by 45 publications

References 34 publications

Regulation of fat metabolism during resistance exercise in sedentary lean and obese men

Regulation of fat metabolism during resistance exercise in sedentary lean and obese men

Behavioral and physiological regulation of body fatness: a cross-sectional study in elderly men

Lipid Oxidation According to Intensity and Exercise Duration in Overweight Men and Women

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