Aerobic interval training and continuous training equally improve aerobic exercise capacity in patients with coronary artery disease: The SAINTEX-CAD study

Conraads, Viviane M.; Pattyn, Nele; Maeyer, Cathérine De; Beckers, Paul; Coeckelberghs, Ellen; Cornelissen, Véronique; Denollet, Johan; Frederix, Geert; Goetschalckx, Kaatje; Hoymans, Vicky Y.; Possemiers, Nadine; Schepers, Dirk; Shivalkar, Bharati; Voigt, Jens‐Uwe; Craenenbroeck, Emeline M. Van; Vanhees, Luc

doi:10.1016/j.ijcard.2014.10.155

Cited by 248 publications

(334 citation statements)

References 38 publications

(31 reference statements)

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“…In recent years, the treatment effects of HIT, which is composed of low‐level exercise with short bouts of high‐intensity exercise at 90% to 95% of peak heart rate, were tested prospectively in different patient populations. Contrary to the promising results of smaller trials, the SAINTEX‐CAD (Study on Aerobic Interval Exercise Training in CAD Patients) failed to show an additional improvement in peak oxygen uptake and endothelial function with HIT compared with MCT in patients with CAD 116. In patients with heart failure, HIT was not associated with additional reverse left ventricular remodeling or peak oxygen uptake compared with MCT in the SMARTEX‐HF (Study of Myocardial Recovery After Exercise Training in Heart Failure) trial 77.…”

Section: Exercise Prescriptionmentioning

confidence: 73%

“…The authors, therefore, speculated that the total energy spent on exercise training is more important to increasing peak oxygen uptake than exercise intensity 117. The number of serious adverse events with HIT was low and did not differ from MCT in patients with CAD 116, 118. In patients with heart failure, serious adverse events were numerically higher with HIT than with MCT.…”

Section: Exercise Prescriptionmentioning

confidence: 99%

See 1 more Smart Citation

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Winzer

Woitek

Linke

2018

JAHA

172

120

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Section: Exercise Prescriptionmentioning

confidence: 73%

Section: Exercise Prescriptionmentioning

confidence: 99%

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Winzer

Woitek

Linke

2018

JAHA

172

120

View full text Add to dashboard Cite

“…One possible explanation for this deviation from previously documented benefits is that average peak HR was relatively high in the MICT group compared with prior trials (80% of predicted). 58 Similarly, the SMARTEX Heart Failure Study, a multi-center RCT involving 261 patients, failed to find a benefit from HIIT in comparison to MICT. 59 However, control of ET intensity in different cohorts was imprecise; those in the ET cohort had only 15 out of 77 ET sessions at an intensity consistent with their HIIT protocol; and of 65 patients in the MICT group, 33 exercise at higher than prescribed intensity.…”

Section: Role Of Exercise Intensitymentioning

confidence: 99%

Impact of cardiac rehabilitation and exercise training programs in coronary heart disease

Kachur

Chongthammakun

Lavie

et al. 2017

Progress in Cardiovascular Diseases

128

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“…13,[16][17][18] Wisloff, et al reported that improvement of peak oxygen uptake was greater in HIIT as compared with moderate aerobic training in patients with heart failure after myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

High-Intensity Interval Training for Severe Left Ventricular Dysfunction Treated with Left Ventricular Assist Device

et al. 2018

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SummaryAerobic training based on anaerobic threshold (AT) is well-known to improve cardiac function, exercise capacity, and long-term outcomes of patients with heart failure. Recent reports suggested that high-intensity interval training (HIIT) for patients with cardiovascular disease may improve cardiopulmonary exercise capacity. We present a 61-year-old male patient of severe left ventricular dysfunction with left ventricular assisted device (LVAD). Following HIIT for 8 weeks, exercise capacity and muscle strength have improved without worsening left ventricular function. Our case showed the possibility that HIIT was feasible and effective even in patients with LVAD.(Int Heart J 2018; 59: 216-219) Key words: Exercise training, Left ventricular assist device, Peak oxygen uptake, Muscle strength S everal controlled trials have demonstrated that exercise training improved exercise capacity and quality of life of patients with heart failure.1-8) And a metaanalysis of randomized trials showed that exercise training for patients with heart failure improved exercise capacity and reduced cardiovascular events.1,9-11) However, continuous moderate-intensity aerobic training is only limited to patients with preserved exercise capacity and muscle strength. Patients with severe deconditioning or muscle weakness are intolerant to continuous moderate-intensity aerobic training.Recently high-intensity interval training (HIIT) has been reported to improve exercise capacity of patients with severely impaired left ventricular function.12,13) HIIT may be feasible for patients who are intolerant to continuous moderate-intensity aerobic training because of deconditioning. It may be difficult for the patient with implantable left ventricular assist device (LVAD) to perform continuous moderate-intensity aerobic training because of longstanding deconditioning, but the patient with LVAD may be a good candidate for HIIT. We present a case of patients with LVAD that was treated by HIIT. Case ReportA 61-year-old male, who was diagnosed with dilated cardiomyopathy (DCM) and treatment-refractory heart failure dependent on inotropic agent, was transferred to our institute for left ventricular assist device (LVAD) implantation. During admission, the patient was 166.3 cm tall and weighed 68.5 kg, with a BMI of 24.9, blood pressure 94/74 mmHg, resting heart rate 105/minute, and body temperature of 36.2°C. Blood biochemistry showed T.P. 7.1 g/dL, albumin 3.8 g/dL, T-bil 3.7 mg/dL, D-bil 2.5 mg/dL, AST 43 IU/mL, ALT 35 IU/mL, LDH 378 mg/dL, CK 168 mg/dL, ALP 324 mg/dL, gamma-GTP 60 mg/dL, CRP 0.69 mg/dL, Na 137 mEq/L, K 4.4 mEq/L, Cl 97 mEq/L, BUN 43 mg/dL, Cr 1.45 mg/dL, UA 10.7 mg/dL, T-chol 154 mg/dL, HDL-C 34 mg/dL, TG 83 mg/ dL, WBC 5490/mm 3 , RBC 493 10 6 /mm 3 , Hb 15.5 g/ dL, Ht 48%, Plt 15.7 104/mm 3 . The plasma glucose level was 210 mg/dL and the BNP level was 3085 pg/mL. Chest X-ray on admission showed slight pleural effusion and cardiomegaly. Echocardiography (ECG) on admission showed sinus tachycardia with a heart rate of 110 BPM, ...

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Aerobic interval training and continuous training equally improve aerobic exercise capacity in patients with coronary artery disease: The SAINTEX-CAD study

Abstract: Contrary to earlier smaller trials, we observed similar improvements in exercise capacity and peripheral endothelial function following AIT and ACT in a large population of CAD patients.

Cited by 248 publications

References 38 publications

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Impact of cardiac rehabilitation and exercise training programs in coronary heart disease

High-Intensity Interval Training for Severe Left Ventricular Dysfunction Treated with Left Ventricular Assist Device

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