Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats

Pietrelli, Adriana; Matkovic, Laura Beatriz; Vacotto, Marina; López‐Costa, Juan José; Basso, Nidia; Brusco, Alicia

doi:10.1016/j.nlm.2018.05.007

Cited by 71 publications

(38 citation statements)

References 70 publications

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“…33 Potential The VBM analyses were adjusted for age (modeled continuously using restricted cubic splines), sex (male, female), educational level (<10, 10, endocrinal mechanisms of anti-inflammatory factors and neurotrophins such as brainderived neurotrophic factor that have been found to be linked to increased physical activity and CRF 34,35 might play a major role in neuroplastic effects, neuromodulation, and recovery, which might lead to improved brain health and slower cognitive decline. 36 In addition, the observed interaction of age with VO 2 peak and W max on the hippocampal volume indicates a stronger benefit of higher CRF in those 45 years and older.…”

Section: Associations Of Relative Crf Measures With Global and Local mentioning

confidence: 94%

Cardiorespiratory Fitness and Gray Matter Volume in the Temporal, Frontal, and Cerebellar Regions in the General Population

Wittfeld

Jochem

Dörr

et al. 2020

Mayo Clinic Proceedings

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Section: Associations Of Relative Crf Measures With Global and Local mentioning

confidence: 94%

Cardiorespiratory Fitness and Gray Matter Volume in the Temporal, Frontal, and Cerebellar Regions in the General Population

Wittfeld

Jochem

Dörr

et al. 2020

Mayo Clinic Proceedings

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“… Etnier et al (2016) showed that long-term memory differed as a function of exercise intensity with better results being presented after maximal intensity levels, although BDNF increase after all exercise intensities. Pietrelli et al (2018) presented data showing that exercise improves memory and learning thru the system serotonin-BDNF, protecting the brain against deleterious effects. These data demonstrate that both acute and chronic changes are associated with improved memory, learning and cognition, and are corroborated by other studies in several other conditions ( Hopkins and Bucci, 2010 ; Hopkins et al, 2011 ; Håkansson et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Significant Acute Response of Brain-Derived Neurotrophic Factor Following a Session of Extreme Conditioning Program Is Correlated With Volume of Specific Exercise Training in Trained Men

et al. 2018

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Several studies have demonstrated an acute and chronic increase of brain-derived neurotrophic factor (BDNF) in relation to different types of physical exercise. Currently, many individuals seek physical training strategies that present different types of stimulation and volume/intensity. Thus, the extreme conditioning methodology has gained great notoriety in the scientific and non-scientific environment. Knowing that BDNF values increase in an effort-dependent manner, it is necessary to study the effects of this strategy on BDNF levels. This study aimed to evaluate the acute response of BDNF in trained men submitted to an extreme conditioning program (ECP) session. Ten volunteers underwent an acute ECP session using the “as many reps as possible” (WOD-AMRAP) method, including three types of exercise (clean, wall ball and double or single-unders) for 9 min. BDNF was measured in the plasma, being collected baseline and immediately after the session. Total load of the clean exercise was five times greater than wall ball exercise (p < 0.05; 2096.1 ± 387.4 kg vs 415.8 ± 81.03 kg), which influenced little in the total load (p < 0.05, 2511.9 ± 358.52 kg) used. For the total volume, practitioners averaged 1.7 times more repetitions in the wall ball exercise compared to clean (46.2 ± 9 vs 29.5 ± 3.8 repetitions). The volunteers averaged 75.7 ± 12.6 double-unders repetitions, bringing the total volume of training to 151.4 ± 23.7 repetitions. Regarding the BDNF values, there was a significant difference (p = 0.05) between the pre- vs post-moments (11209.85 ± 1270.4 vs 12132.96 ± 1441.93 pg/ml). Effect size for this change as moderate (ES = 0.79). We found a positive correlation between total volume of clean exercise and delta BDNF values (p = 0.049). In conclusion, a single extreme conditioning session, through the practice of the WOD-AMRAP method, is capable of increasing the acute concentrations of plasma BDNF. In practical terms, we may suggest that future studies evaluate the effect of ECP as a strategy in the treatment of disorders associated with central degenerative changes.

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“…La función de la serotonina (5HT) y sus múltiples receptores ha sido ampliamente estudiada en distintas funciones como el estado de ánimo, la regulación de la ansiedad y la agresión, el sueño y como modulador del dolor [26][27][28].…”

Section: Sistema Serotoninérgicounclassified

Mecanismos Neurocognitivos de la motivación en el entrenamiento físico

Bertone

Loskin

Obando

et al. 2020

Rev. Investig. Innov. Cienc. Salud

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La inactividad física y el sedentarismo son en la actualidad un problema de salud global que preocupa por su crecimiento sistemático. Provoca consecuencias sanitarias en los adultos y, con un incremento alarmante, en la población más joven. Por el contrario, la realización periódica de actividad física ha demostrado beneficios a la salud física, neurológica y mental. A pesar de los incontrovertibles datos sobre sus efectos positivos, menos de la mitad de la población mundial se ejercita regularmente. El objetivo de este trabajo es realizar una breve descripción sobre los mecanismo neurocognitivos que se encuentran implicados en los procesos de motivación, en especial los que se vinculan a la actividad física, con la finalidad de presentar una serie de recomendaciones pragmáticas para aumentar la adherencia a programas de entrenamiento físico, basados en técnicas de la psicología cognitiva y analizados desde la perspectiva neurocognitiva.

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Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats

Cited by 71 publications

References 70 publications

Cardiorespiratory Fitness and Gray Matter Volume in the Temporal, Frontal, and Cerebellar Regions in the General Population

Cardiorespiratory Fitness and Gray Matter Volume in the Temporal, Frontal, and Cerebellar Regions in the General Population

Significant Acute Response of Brain-Derived Neurotrophic Factor Following a Session of Extreme Conditioning Program Is Correlated With Volume of Specific Exercise Training in Trained Men

Mecanismos Neurocognitivos de la motivación en el entrenamiento físico

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