Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats.

Ezzat, Wessam; Hamid, Manal S. Abd-El

doi:10.1016/j.jadr.2021.100268

Cited by 5 publications

(7 citation statements)

References 57 publications

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“…However, limited research has examined the effectiveness of exercise ther- Regular physical activity has been shown to alleviate the extent of symptoms related to hypothyroidism, including depression and sleep disturbances [46]. The effectiveness of exercise training as an antidepressant might be attributed to its ability to increase brain serotonin levels [27]. Additionally, it is noteworthy that serotonin enhances synaptic plasticity in the hippocampus, potentially aiding in alleviating symptoms linked to depression [47]; moreover, the secretion of brain-derived neurotrophic factor might be linked to the effects of engaging in physical exercise [48].…”

Section: Discussionmentioning

confidence: 99%

“…In hypothyroidism, AE resulted in considerable declines in depressive symptoms [26,27], while RE was found to induce superior benefits on sleep in those with sleep disturbances [28] and more improvements in depression in depressed and non-depressed youths compared to AE [29]. Furthermore, exercise programs that integrate both aerobic and resistance training have proven to be more advantageous for older persons who suffer from clinical depression [30].…”

Section: Original Articlementioning

confidence: 99%

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Comparative effects of aerobic, resistance, and combined exercises on depression and sleep quality in women with controlled hypothyroidism. A randomized controlled trial

Elgayar,

Elgendy,

Youssef

2024

areh

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Introduction: Interest has recently frown in the use of exercise in managing hypothyroidism associated impairments. The objective of this research was to assess and contrast the effects of aerobic and resistance exercise regimens, and a combination of both, on depressive symptoms and sleep quality in women with managed hypothyroidism. Material and methods: A total of sixty women, aged 35 to 45 years, with controlled hypothyroidism associated with depression, and sleep problems were randomly assigned to four equally-sized groups: aerobic exercise (AE), resistance exercise (RE), combined AE/RE, and a control group. They engaged in low to moderate intensity workouts, three times a week, during a span of 12 weeks, while also undergoing levothyroxine therapy. Outcome measures included depression assessed with the Beck Depression Inventory II (BDI-II) and sleep quality, evaluated using the Pittsburgh Sleep Quality Index (PSQI). Results: The BDI-II and PSQI showed significant improvements in all exercise groups in comparison to the first measurements and the non-exercising group (p < 0.05). Most significantly, the AE/RE group demonstrated greater improvements in both outcomes then the AE and RE groups alone (p < 0.05). Conclusions: In well-managed hypothyroid women, AE, RE, and combined AE/RE can improve depression and sleep quality. However, combined AE/RE appears to induce the greatest improvements in both measures.

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Section: Discussionmentioning

confidence: 99%

Section: Original Articlementioning

confidence: 99%

Comparative effects of aerobic, resistance, and combined exercises on depression and sleep quality in women with controlled hypothyroidism. A randomized controlled trial

Elgayar,

Elgendy,

Youssef

2024

areh

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“…37 However, exercise and antidepressant agents improve the synthesis of BDNF. 38 Peripheral BDNF is derived from platelets, vascular and epithelial cells, leukocytes and macrophages. 39 Peripheral BDNF cannot cross BBB and less contributes to brain regulation.…”

Section: B Dnf Overvie Wmentioning

confidence: 99%

BDNF/TrkB activators in Parkinson's disease: A new therapeutic strategy

Ali,

Al‐Kuraishy,

Al‐Gareeb

et al. 2024

J Cellular Molecular Medi

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Parkinson's disease (PD) is a neurodegenerative disorder of the brain and is manifested by motor and non‐motor symptoms because of degenerative changes in dopaminergic neurons of the substantia nigra. PD neuropathology is associated with mitochondrial dysfunction, oxidative damage and apoptosis. Thus, the modulation of mitochondrial dysfunction, oxidative damage and apoptosis by growth factors could be a novel boulevard in the management of PD. Brain‐derived neurotrophic factor (BDNF) and its receptor tropomyosin receptor kinase type B (TrkB) are chiefly involved in PD neuropathology. BDNF promotes the survival of dopaminergic neurons in the substantia nigra and enhances the functional activity of striatal neurons. Deficiency of the TrkB receptor triggers degeneration of dopaminergic neurons and accumulation of α‐Syn in the substantia nigra. As well, BDNF/TrkB signalling is reduced in the early phase of PD neuropathology. Targeting of BDNF/TrkB signalling by specific activators may attenuate PD neuropathology. Thus, this review aimed to discuss the potential role of BDNF/TrkB activators against PD. In conclusion, BDNF/TrkB signalling is decreased in PD and linked with disease severity and long‐term complications. Activation of BDNF/TrkB by specific activators may attenuate PD neuropathology.

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“…12 A eficácia antidepressiva do treinamento aeróbico moderado pode ser atribuída à capacidade do exercício aeróbico de elevar os níveis de serotonina no cérebro. 32 Além disso, é notável que a serotonina amplifique a plasticidade sináptica do hipocampo, o que poderia potencialmente contribuir para a mitigação dos sintomas associados à depressão. 33 Além disso, a liberação de fator neurotrófico derivado do cérebro pode estar potencialmente associada aos impactos do exercício físico.…”

Section: Depressãounclassified

Effect of aerobic training on depression and thyroid function in treated hypothyroid women

Gayar

2023

Rev Pesq Fisio

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INTRODUCTION: Hypothyroidism is commonly associated with depression and a slowing in mental activity. OBJECTIVES: The current investigation aimed to investigate the effect of aerobic training on depression and thyroid function in treated hypothyroid females. METHODS AND MATERIALS: Thirty women diagnosed with primary hypothyroidism that was regulated and accompanied by mild to moderate levels of depression completed a 12-week randomized controlled exercise trial involving two equal groups: aerobic (n = 15) and control (n = 15) groups. The exercising group performed three sessions of aerobic exercise per week at low to moderate intensity for 12 consecutive weeks while the control group performed no exercise intervention during the same duration. At baseline and post-intervention, Beck Depression Inventory score (BDIS), thyroid stimulating hormone (TSH) and free thyroxin (T4) were assessed. RESULTS: The exercising group showed significant improvements in BDIS, TSH and free T4 compared to baseline (p < 0.05) with negligible change in the control group (p > 0.05). As compared to the control, all measured items differed significantly in favor to the aerobic training group. CONCLUSION: In women with treated hypothyroidism, aerobic training can minimize depressive symptoms and enhance thyroid function.

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Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats.

Cited by 5 publications

References 57 publications

Comparative effects of aerobic, resistance, and combined exercises on depression and sleep quality in women with controlled hypothyroidism. A randomized controlled trial

Comparative effects of aerobic, resistance, and combined exercises on depression and sleep quality in women with controlled hypothyroidism. A randomized controlled trial

BDNF/TrkB activators in Parkinson's disease: A new therapeutic strategy

Effect of aerobic training on depression and thyroid function in treated hypothyroid women

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