Aerobic exercise increases resistance to oxidative stress in sedentary older middle-aged adults. A pilot study

Done, Aaron J.; Traustadóttir, Tinna

doi:10.1007/s11357-016-9942-x

Cited by 19 publications

(11 citation statements)

References 31 publications

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“…It has been demonstrated that the acute exercise increases resistance to oxidative stress in young but not older adults, 32 , 33 likewise that regular exercise with improved fitness leads to increased resistance to oxidative stress in older middle-aged adults. 34 However, it has also been found that chronic exercise from middle age to old age increases oxidative damage. 35 …”

Section: Discussionmentioning

confidence: 99%

“…In this respect, our results show that in the study population whose activity level is moderate (4-6 METs, aerobic capacity entertains a direct relationship with energy-expenditure markers, which confirms that individuals who perform greater physical activity also have a higher energy expenditure, and consequently, their capacity for utilizing oxygen is greater, as has been noted in some other studies. 34 , 36 …”

Section: Discussionmentioning

confidence: 99%

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Relationship Between Aerobic Capacity With Oxidative Stress and Inflammation Biomarkers in the Blood of Older Mexican Urban-Dwelling Population

Rosado-Pérez

Mendoza-Núñez

2018

Dose-Response

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The maximal oxygen uptake (VO2max) constitutes an indicator of an organism’s capacity to integrate oxygen into the metabolism to obtaining energy. The aim of this study was to determine the relationship between VO2max and oxidative stress (OxS) and chronic inflammation in the elderly individuals. A cross-sectional and exploratory study was conducted in a sample of 52 older persons. We measured plasma lipid peroxides (LPO), red blood cell glutathione peroxidase, red blood cell superoxide dismutase, and total antioxidant status. The interleukin 10 and tumor necrosis factor-α (TNF-α) were measured in serum by ELISA. The VO2max was determined by the Rockport aerobic test, and the energy expenditure (caloric expenditure and metabolic equivalence unit (MET) per day) was measured by a 3-day activity record. We observed a positive correlation between VO2 max with IL-10, MET/day•day-1 and kcal•day-1 (r = 0.31, P < .05, r = 0.44, P < .01, and r = 0.29, P < .05, respectively), and a negative correlation with the body mass index, TNF-α, and LPO (r = −0.27, P < .05, r = −0.29, P < .05, and r = −0.40, P < .01 respectively). Our findings suggest that there is an inverse relationship between the aerobic capacity and the OxS and chronic inflammation biomarkers in the blood in older Mexican adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship Between Aerobic Capacity With Oxidative Stress and Inflammation Biomarkers in the Blood of Older Mexican Urban-Dwelling Population

Rosado-Pérez

Mendoza-Núñez

2018

Dose-Response

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“…Accordingly, Zarrindast et al stated that moderate-intensity aerobic training for eight weeks on the land and water reduces oxidative stress and improves antioxidant status [ 67 ]. Moreover, Done et al concluded that regular aerobic exercise increases resistance to oxidative stress [ 68 ]. Estébanez et al showed that aerobic exercise does not cause significant changes in the oxidative stress biomarkers among the elderly [ 69 ].…”

Section: The Influence Of the Physical Exercise On Oxidative Stresmentioning

confidence: 99%

Creatine Supplementation, Physical Exercise and Oxidative Stress Markers: A Review of the Mechanisms and Effectiveness

2021

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Oxidative stress is the result of an imbalance between the generation of reactive oxygen species (ROS) and their elimination by antioxidant mechanisms. ROS degrade biogenic substances such as deoxyribonucleic acid, lipids, and proteins, which in turn may lead to oxidative tissue damage. One of the physiological conditions currently associated with enhanced oxidative stress is exercise. Although a period of intense training may cause oxidative damage to muscle fibers, regular exercise helps increase the cells’ ability to reduce the ROS over-accumulation. Regular moderate-intensity exercise has been shown to increase antioxidant defense. Endogenous antioxidants cannot completely prevent oxidative damage under the physiological and pathological conditions (intense exercise and exercise at altitude). These conditions may disturb the endogenous antioxidant balance and increase oxidative stress. In this case, the use of antioxidant supplements such as creatine can have positive effects on the antioxidant system. Creatine is made up of two essential amino acids, arginine and methionine, and one non-essential amino acid, glycine. The exact action mechanism of creatine as an antioxidant is not known. However, it has been shown to increase the activity of antioxidant enzymes and the capability to eliminate ROS and reactive nitrogen species (RNS). It seems that the antioxidant effects of creatine may be due to various mechanisms such as its indirect (i.e., increased or normalized cell energy status) and direct (i.e., maintaining mitochondrial integrity) mechanisms. Creatine supplement consumption may have a synergistic effect with training, but the intensity and duration of training can play an important role in the antioxidant activity. In this study, the researchers attempted to review the literature on the effects of creatine supplementation and physical exercise on oxidative stress.

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“…The long-lasting effects of exercise on oxidative stress and its relationship with cardiovascular diseases is controversial, mainly because of the differences among the type, intensity, frequency and duration of the exercise programs found in the literature. Moreover, most of the studies concerned with physical exercise and related oxidative stress have concentrated on the effects of CVT [ 24 , 25 ], resistance training (RT) [ 26 ] or a combined cardiovascular and resistance training (CT) [ 18 , 27 , 28 ] on oxidative stress mainly in healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

Effects of Cardiovascular, Resistance and Combined Exercise Training on Cardiovascular, Performance and Blood Redox Parameters in Coronary Artery Disease Patients: An 8-Month Training-Detraining Randomized Intervention

et al. 2021

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It is well-documented that chronic/regular exercise improves the cardiovascular function, decreases oxidative stress and enhances the antioxidant capacity in coronary artery disease (CAD) patients. However, there is insufficient evidence regarding the chronic effects of different types of training and detraining on cardiovascular function and the levels of oxidative stress and antioxidant status in these patients. Therefore, the present study aimed at investigating the effects of cardiovascular, resistance and combined exercise training followed by a three-month detraining period, on cardiovascular function, physical performance and blood redox status parameters in CAD patients. Sixty coronary artery disease patients were randomly assigned to either a cardiovascular training (CVT, N = 15), resistance training (RT, N = 11), combined cardiovascular and resistance training (CT, N = 16) or a control (C, N = 15) group. The training groups participated in an 8-month supervised training program (training three days/week) followed by a 3-month detraining period, while the control group participated only in measurements. Body composition, blood pressure, performance-related variables (aerobic capacity (VO2max), muscle strength, flexibility) and blood redox status-related parameters (thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC), reduced glutathione (GSH), oxidized glutathione (GSSG), catalase activity (CAT), protein carbonyls (PC)) were assessed at the beginning of the study, after 4 and 8 months of training as well as following 1, 2 and 3 months of detraining (DT). CVT induced the most remarkable and pronounced alterations in blood pressure (~9% reduction in systolic blood pressure and ~5% in diastolic blood pressure) and redox status since it had a positive effect on all redox-related variables (ranging from 16 to 137%). RT and CT training affected positively some of the assessed (TAC, CAT and PC) redox-related variables. Performance-related variables retained the positive response of the training, whereas most of the redox status parameters, for all training groups, restored near to the pre-exercise values at the end of the DT period. These results indicate that exercise training has a significant effect on redox status of CAD. Three months of detraining is enough to abolish the exercise-induced beneficial effects on redox status, indicating that for a better antioxidant status, exercise must be a lifetime commitment.

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Aerobic exercise increases resistance to oxidative stress in sedentary older middle-aged adults. A pilot study

Cited by 19 publications

References 31 publications

Relationship Between Aerobic Capacity With Oxidative Stress and Inflammation Biomarkers in the Blood of Older Mexican Urban-Dwelling Population

Relationship Between Aerobic Capacity With Oxidative Stress and Inflammation Biomarkers in the Blood of Older Mexican Urban-Dwelling Population

Creatine Supplementation, Physical Exercise and Oxidative Stress Markers: A Review of the Mechanisms and Effectiveness

Effects of Cardiovascular, Resistance and Combined Exercise Training on Cardiovascular, Performance and Blood Redox Parameters in Coronary Artery Disease Patients: An 8-Month Training-Detraining Randomized Intervention

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