Aerobic capacity in patients with chronic liver disease: Very modest effect of liver transplantation

Lemyze, Malcolm; Dharancy, Sébastien; Nevière, R.; Pruvot, François‐René; Declerck, Nicole; Wallaert, B.

doi:10.1016/j.lpm.2009.09.027

Cited by 26 publications

(30 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 20 patients tested before and at 16.3 months after LTx, and undergoing no formal exercise rehabilitation program, theVo 2peak was increased by 14.3% when expressed in absolute terms (L.min −1 ) and by 13.7% in relative terms (from ∼19.0 to ∼20.6 ml.kg −1 .min −1 ), which was a gain of 7.7% of predicted values (166 Pieber et al examined submaximal exercise capability and muscle strength in 12 patients before, at 1 to 2 months post-Tx, and after 3 years in a small subgroup (252). Liver Tx exhibited low preoperative exercise AT, quadriceps and handgrip muscle strength (252); unfortunatelyVo 2peak was not measured.…”

Section: Peak Exercise Performance After Liver Transplantationmentioning

confidence: 88%

Exercise Limitation Following Transplantation

Williams

McKenna

2012

Comprehensive Physiology

View full text Add to dashboard Cite

Organ transplantation is one of the medical miracles or the 20th century. It has the capacity to substantially improve exercise performance and quality of life in patients who are severely limited with chronic organ failure. We focus on the most commonly performed solid‐organ transplants and describe peak exercise performance following recovery from transplantation. Across all of the common transplants, evaluated significant reduction in o 2 peak is seen (typically renal and liver 65%‐80% with heart and/or lung 50%‐60% of predicted). Those with the lowest o 2 peak pretransplant have the lowest o 2 peak posttransplant. Overall very few patients have a o 2 peak in the normal range. Investigation of the cause of the reduction of o 2 peak has identified many factors pre‐ and posttransplant that may contribute. These include organ‐specific factors in the otherwise well‐functioning allograft (e.g., chronotropic incompetence in heart transplantation) as well as allograft dysfunction itself (e.g., chronic lung allograft dysfunction). However, looking across all transplants, a pattern emerges. A low muscle mass with qualitative change in large exercising skeletal muscle groups is seen pretransplant. Many factor posttransplant aggravate these changes or prevent them recovering, especially calcineurin antagonist drugs which are key immunosuppressing agents. This results in the reduction of o 2 peak despite restoration of near normal function of the initially failing organ system. As such organ transplantation has provided an experiment of nature that has focused our attention on an important confounder of chronic organ failure‐skeletal muscle dysfunction. © 2012 American Physiological Society. Compr Physiol 2:1937‐1979, 2012.

show abstract

Section: Peak Exercise Performance After Liver Transplantationmentioning

confidence: 88%

Exercise Limitation Following Transplantation

Williams

McKenna

2012

Comprehensive Physiology

View full text Add to dashboard Cite

show abstract

“…A relação existente entre a força do aperto de mão e o VO 2max em indivíduos cirróticos encontrada em nosso estudo (Figura 1) pode ser explicada pelas alterações encontradas na vasodilatação desses indivíduos interferindo na vasoconstrição arteriolar causando desvio do fluxo sanguíneo dos tecidos não ativos para os músculos esqueléticos em exercício, limitando a extração de oxigênio que é verificada em praticamente todos os pacientes com cirrose hepática cujo a magnitude desse prejuízo aumenta com a progressão da doença 18,19 . O presente estudo teve como limitações a ausência de mensuração do tratamento medicamentoso para o VHC e sobre a presença de comorbidades como diabete mellitus tipo 2 e hipertensão arterial sistêmica, uma vez que o VO 2MAX possui associação com sexo, idade, presença de doenças e uso de medicações em pacientes hepatopatas 20,21 .…”

Section: Discussionunclassified

Alterações Do Sistema Cardiopulmonar De Pacientes Cirróticos

Vieira

Álvares‐da‐Silva

Oliveira

et al. 2017

Rev Bras Med Esporte

View full text Add to dashboard Cite

Introdução: A cirrose gera alterações nas trocas gasosas e a desnutrição proteico-calórica em pacientes hepatopatas. Objetivo: Avaliar e comparar as variáveis cardiopulmonares, a força do aperto de mão (FAM) e a composição corporal entre pacientes cirróticos pelo vírus da hepatite C e indivíduos saudáveis, e correlacionar o consumo máximo de oxigênio (VO 2MAX ) com a FAM. Métodos: Esta pesquisa caracteriza-se como estudo de caso-controle composto por 36 participantes (18 pacientes cirróticos com HCV e 18 indivíduos hígidos) de ambos os sexos, maiores de 18 anos. A força de preensão palmar foi mensurada por dinamometria com dinamômetro mecânico de empunhadura com alça ajustável. As variáveis ventilatórias foram avaliadas por ergoespirometria com teste de carga progressiva em cicloergômetro. A composição corporal foi mensurada por um técnico em cineantropometria nível II. Foram utilizados os testes t independente e Mann-Whitney para comparação entre os grupos e a correlação de Spearman para associação entre as variáveis. Resultados: Foram encontradas diferenças no consumo máximo de oxigênio 16,20 (11,60-18,55), mediana e intervalo interquartil x 19,90 (16,27-26,85), ventilação 45,40 (36,45-54,20) x 63,40 (50,40-78,00), produção de dióxido de carbono 785,88 (655,81-963,14) x 988,04 (826,21), frequência cardíaca máxima (127,66 ± 23,26 média e ± DP) x (146,29 ± 23,31), primeiro limiar ventilatório (10,700 ± 3,19) x (14,912 ± 4,45) e segundo limiar ventilatório (14,16 ± 4,48) x (18,25 ± 5,54) entre cirróticos e controles, respectivamente. Encontramos correlação positiva moderada entre o consumo máximo de oxigênio e a força do aperto de mão (r = 0,474, p = 0,047). Conclusão: Existem alterações nas variáveis cardiopulmonares e há associação entre o VO 2MAX e a FAM em pacientes cirróticos pelo vírus da hepatite C.Descritores: força da mão; cirrose hepática; consumo de oxigênio. 16.20 (11.60-18.55), median and interquartile range x 19.90 (16.27-26.85), ventilation 45.40 (36.45-54.20) x 63.40 (50.40-78.00), carbon dioxide production 785.88 (655.81-963.14) x 988.04 (826.93-1546.21), maximum heart rate (127.66 ± 23.26, mean and ± SD) x (146.29 ± 23.31), first ventilatory threshold (10.700 ± 3.19) x (14.912 ± 4.45) and second ventilatory threshold (14.16 ± 4.48) x (18.25 ± 5.54) ABSTRACT

show abstract

“…On the other hand, in another study (31) it was concluded that patients that who underwent hepatic transplantation presented greater exercise capacity after the surgery. Therefore, exercise capacity testing may be a valuable tool to improve allocation of patients in transplantation waiting lists (28).…”

Section: Exercise Capacity Before and After Hepatic Transplantationmentioning

confidence: 93%

“…The exercise capacity of subjects with hepatic cirrhosis was assessed using oxygen consumption on maximum cardiopulmonary tests on fifteen different articles (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). These studies are described on table 1.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The influence that hepatic cirrhosis provides in exercise capacity and muscle strength: a review

2015

View full text Add to dashboard Cite

Introduction: Hepatic cirrhosis leads to a series of physiological changes, among which stand out cardiorespiratory and muscle impairments. These changes determine a negative impact on quality of life and may cause physical inactivity. Objective: The objective of this study was to review, in the most current scientific literature, the influence that hepatic cirrhosis provides in exercise capacity and muscle strength, and the effect of exercise when applied to this situation. Materials and methods: For this review, research on original studies was carried out on Medical Literature Analysis and Retrieval System Online (assessed by PubMed), Scopus and Web of Science between the years 1990 to 2015. In order to be included, studies had to meet the following criteria: a) be from original articles; b) evaluate exercise capacity or muscle strength; and c) provide relevant results. Results and Discussion: The majority of studies concluded that the exercise capacity and muscle strength are decreased in individuals with cirrhosis when compared to control subjects.

show abstract

Aerobic capacity in patients with chronic liver disease: Very modest effect of liver transplantation

Cited by 26 publications

References 20 publications

Exercise Limitation Following Transplantation

Exercise Limitation Following Transplantation

Alterações Do Sistema Cardiopulmonar De Pacientes Cirróticos

The influence that hepatic cirrhosis provides in exercise capacity and muscle strength: a review

Contact Info

Product

Resources

About