ADVIA 2120i peut-il remplacer le frottis sanguin ?

Abstract

Introduction. The ADVIA 2120i is one of the most efficient analyzer used in hematology laboratories. In addition to the quantification of cells; it enables the detection of cytological abnormalities and alert biologist by specific alarms. Material and methods. We conducted a prospective study in the EHU Oran for 3 month. Overall, 146 blood samples were analyzed for which the analyser reported various cytological alarms and we reviewed them under the microscope as a gold standard. Results. This study allowed us to determine how the ADVIA 2120i can be helpful for routine use in screening cytological abnormalities. According to our results it turned out that the analyser is efficient for erythrocyte morphological abnormalities such as microcytosis, macrocytosis, hypochromy and anisocytosis. However, concerning leukocytes; we found a high rate of false positive cases, the specificity should be improved especially for detection of blasts.

Perbedaan Jumlah Blast pada Hitung Manual dengan Alat Hematologi Siemens Advia 2120i

“…This is likely due to the low threshold set by tool manufacturers so that users remain careful in diagnosing leukemia so that cytological examination is still needed in diagnosing acute leukemia. 12,14,20 Research by Meintker et al also states that the presence of Immature Granulocytes (IG) can cause the calculation of the number of blasts on the Siemens ADVIA 2120i hematology instrument to be falsely high or falsely low. 12 This study obtained the number of blasts for the myelocytic series using a manual counting method that differed from the Siemens ADVIA 2120i hematology instrument.…”